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Protein Overview: EG10420

General Information:
Name(s) found: guaA / EG10420 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • GMP synthetase (glutamine aminotransferase) / GMP synthase [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 525 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: NAD biosynthetic process [IEA]
    glutamine metabolic process [IEA]
    GMP biosynthetic process [IEA][IMPLink to PubMed article]
    Molecular Function: nucleotide binding [IEA]
    NAD+ synthase (glutamine-hydrolyzing) activity [IEA]
    ATP binding [IEA]
    protein binding [IPILink to PubMed article]
    GMP synthase activity [IDALink to PubMed article]
    GMP synthase (glutamine-hydrolyzing) activity [IDALink to PubMed article][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTENIHKHRI LILDFGSQYT QLVARRVREL GVYCELWAWD VTEAQIRDFN PSGIILSGGP  60
   61 ESTTEENSPR APQYVFEAGV PVFGVCYGMQ TMAMQLGGHV EASNEREFGY AQVEVVNDSA 120
  121 LVRGIEDALT ADGKPLLDVW MSHGDKVTAI PSDFITVAST ESCPFAIMAN EEKRFYGVQF 180
  181 HPEVTHTRQG MRMLERFVRD ICQCEALWTP AKIIDDAVAR IREQVGDDKV ILGLSGGVDS 240
  241 SVTAMLLHRA IGKNLTCVFV DNGLLRLNEA EQVLDMFGDH FGLNIVHVPA EDRFLSALAG 300
  301 ENDPEAKRKI IGRVFVEVFD EEALKLEDVK WLAQGTIYPD VIESAASATG KAHVIKSHHN 360
  361 VGGLPKEMKM GLVEPLKELF KDEVRKIGLE LGLPYDMLYR HPFPGPGLGV RVLGEVKKEY 420
  421 CDLLRRADAI FIEELRKADL YDKVSQAFTV FLPVRSVGVM GDGRKYDWVV SLRAVETIDF 480
  481 MTAHWAHLPY DFLGRVSNRI INEVNGISRV VYDISGKPPA TIEWE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..525] PSI-BLAST 1000.0 GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • anthranilate synthase activity
    		•  2.51214170411838 bayes_pls_golite062009
  • GMP synthase activity
    		•  2.47512732878183 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.4336980737244 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  2.18904295741925 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine synthase activity
    		•  1.83575136996743 bayes_pls_golite062009
  • GMP synthase (glutamine-hydrolyzing) activity
    		•  1.81483405404572 bayes_pls_golite062009
  • ligase activity
    		•  1.7997907410336 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  1.74828881793189 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  1.74029540439985 bayes_pls_golite062009
  • oxo-acid-lyase activity
    		•  1.35896725827905 bayes_pls_golite062009
  • catalytic activity
    		•  0.828867994386867 bayes_pls_golite062009
  • asparagine synthase (glutamine-hydrolyzing) activity
    		•  0.3673193848392 bayes_pls_golite062009
  • imidazoleglycerol-phosphate synthase activity
    		•  0.270391651600004 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.0769356405014503 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle