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Protein Overview: EG12302

General Information:
Name(s) found: tmk / EG12302 [EcoGene]
Description(s) found:
Found 4 descriptions.
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  • thymidylate kinase / Thymidylate kinase [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 213 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: nucleobase, nucleoside and nucleotide interconversion [IDALink to PubMed article]
    dTDP biosynthetic process [IDALink to PubMed article][IEA]
    dTTP biosynthetic process [IDALink to PubMed article][IEA][IMPLink to PubMed article]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    thymidylate kinase activity [IDALink to PubMed articleLink to PubMed article][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSKYIVIEG LEGAGKTTAR NVVVETLEQL GIRDMVFTRE PGGTQLAEKL RSLVLDIKSV  60
   61 GDEVITDKAE VLMFYAARVQ LVETVIKPAL ANGTWVIGDR HDLSTQAYQG GGRGIDQHML 120
  121 ATLRDAVLGD FRPDLTLYLD VTPEVGLKRA RARGELDRIE QESFDFFNRT RARYLELAAQ 180
  181 DKSIHTIDAT QPLEAVMDAI RTTVTHWVKE LDA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 46.0 Thymidylate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  3.31021342806183 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.01286198424677 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  2.24094813695083 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.06460241490722 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.0114051513686 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  1.96697952975573 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.92626167278464 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.9136419736217 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.6854386921174 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.64467072658718 bayes_pls_golite062009
  • kinase activity
    		•  1.60827037072506 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.5008821138859 bayes_pls_golite062009
  • binding
    		•  1.25659194713805 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • nucleotide binding
    		•  0.828524126097217 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.810407092593521 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.810379637652019 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.805605269661092 bayes_pls_golite062009
  • hydrolase activity
    		•  0.420858111948277 bayes_pls_golite062009
  • adenylate kinase activity
    		•  0.373057703057608 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.216266069700019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle