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Protein Overview: EG12089

General Information:
Name(s) found: nuoI / EG12089 [EcoGene]
Description(s) found:
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  • NADH:ubiquinone oxidoreductase, chain I / NADH:ubiquinone oxidoreductase subunit I, complex I; NADH dehydrogenase I [EcoGene]
  • NADH dehydrogenase subunit I [Escherichia coli K12] [nr-271106-contam.fasta]
  • NADH:ubiquinone oxidoreductase, chain I [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • NADH:ubiquinone oxidoreductase, chain I [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 180 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane respiratory chain complex I [IDALink to PubMed article]
    NADH dehydrogenase complex [IDALink to PubMed article]
    [NOT]cytoplasm [IMPLink to PubMed article]
    extrinsic to membrane [IEA]
    plasma membrane [IDALink to PubMed article]
    Biological Process: anaerobic respiration [IMPLink to PubMed article]
    photosynthesis, light reaction [IEA]
    oxidation reduction [IEA]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: NADH dehydrogenase (quinone) activity [IEA]
    oxidoreduction-driven active transmembrane transporter activity [IDALink to PubMed article]
    NADH dehydrogenase activity [IDALink to PubMed article]
    quinone binding [IEA]
    metal ion binding [IEA]
    oxidoreductase activity [IEA]
    iron ion binding [IEA]
    electron carrier activity [IEA]
    oxidoreductase activity, acting on NADH or NADPH [IEA]
    4 iron, 4 sulfur cluster binding [IEA][ISSLink to PubMed article]
    iron-sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLKELLVGF GTQVRSIWMI GLHAFAKRET RMYPEEPVYL PPRYRGRIVL TRDPDGEERC  60
   61 VACNLCAVAC PVGCISLQKA ETKDGRWYPE FFRINFSRCI FCGLCEEACP TTAIQLTPDF 120
  121 EMGEYKRQDL VYEKEDLLIS GPGKYPEYNF YRMAGMAIDG KDKGEAENEA KPIDVKSLLP 180
  181

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] PSI-BLAST 26.69897 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  12.5726198200461 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  11.5379710261128 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  11.4267068380664 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  10.7661444048967 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  10.0573871968611 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  7.6692836424589 bayes_pls_golite062009
  • metal cluster binding
    		•  6.88959428302591 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  6.88959428302591 bayes_pls_golite062009
  • oxidoreductase activity
    		•  5.95698221294919 bayes_pls_golite062009
  • electron carrier activity
    		•  5.42600867641421 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  5.39944360924751 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  4.7946737640663 bayes_pls_golite062009
  • FMN binding
    		•  1.64858327046622 bayes_pls_golite062009
  • binding
    		•  0.668971250367847 bayes_pls_golite062009
  • catalytic activity
    		•  0.488483980994331 bayes_pls_golite062009
  • protein binding
    		•  0.283477223088022 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.0827182678048914 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle