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Protein Overview: ec-PA

General Information:
Name(s) found: ec-PA / FBpp0100019 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene echinus is referred to in FlyBase by the symbol Dmel\ec (CG2904, FBgn0000542). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3705976..3751658. It has the cytological map location 3F2-3F3. It is reported to have molecular function</span>: ubiquitin thiolesterase activity. There is experimental evidence that it is involved in the biological process</span>: compound eye morphogenesis. 40 alleles are reported. The phenotypes of these alleles are annotated with: eye; adult thorax; dorsocentral bristle; primary pigment cell; adult abdomen; posterior notopleural bristle; cone cell; wing; ommatidium. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1712 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: [NOT]protein deubiquitination [IDA]
    compound eye morphogenesis [IMP]
    retinal cell programmed cell death [TAS]
    compound eye retinal cell programmed cell death [TAS]
    ubiquitin-dependent protein catabolic process [IEA]
    Molecular Function: [NOT]ubiquitin-specific protease activity [IDA]
    ubiquitin thiolesterase activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTAAIKTSL PHAPLAGQQQ PQQAQTTTAM AVAPTTITNA QTSAINAKNN IGAFFQTCKV  60
   61 LWHLDAFRRS FRGLNQHVCG GQDCIFCALK ELFQQLQTSS EPALCPEPLR RALASGPLAG 120
  121 RRFPLGCLGD AAECFELLLH RVHSHISPDD GDSCESSACI AHRRFAMRVI EQSVCKCGAN 180
  181 SEQLPFTQMV HYVSASALTS QKSLALQSHQ QLSFGQLLRA AGNMGDIRDC PNTCGAKIGI 240
  241 CRALLNRPEV VSIGIVWDSE RPAADQVHAV LKAVGTSLRL GDVFHQVSEP RWAQQTQHEL 300
  301 VGIVSYYGKH YTTFFFHTKL KVWVYFDDAN VKEVGPSWEG VVDKCSRGRY QPLLLLYAVP 360
  361 QQPTVGNGVG IGHVDVAMPA SAPSIAGSVV RRAVTPSPEK PSLGNTRRAI TPTPLRTPPN 420
  421 DYQNLSVIQK NIFPSNLAMG TDETDAYISR KTVEHVLSAQ YQNLSVIQDK IGGGNGVGVG 480
  481 QQSVDKDGGF LSRKPIEAVL SAQLARRQHL QLQRSHSAES SSGHASSNGS SPPSDGLTMP 540
  541 EHLNQPRRRD SGNWSGDRNS ASSASSTTLD NPYLYMVAKR GVAAVPQSPT RHGLPYDPGY 600
  601 DSFSLSSTDS YPPKHALNPQ LAKIPEAAMG VVPNGGAMPH GHGNGQLALS GDCEKLCHEA 660
  661 DQLLEKSRLV EESHDLETAL VLCNAAAGRA RAAMDAPYSN PHTMTFARMK HNTCVMRARS 720
  721 LHRRILVEKG AETEAMPELK HMREGSTSSV KHVRQNSKDR TLEKEQQQLQ FQQIQQIQQI 780
  781 HQIQQQIPAS IEIYATLPKR KSPLKALASA SACDDNAIEY EQEKQLATSP GKPERESRSL 840
  841 FGRKDKEKEK RSRSEDRNKL TREFSLTETL LVNAKDTLKK HKEDKDEKKE KDKSGKKQHK 900
  901 IRRKLLMGGL IRRKNRSMPD LTEAVDDSTA NAGITHHPHY PAQGVTTAGT LLGTSVDDSA 960
  961 VGLGKHGHGM SGYISEGHFD YSGSGSASNS GAGSNPNPNL ERSKLMRKSF HGSGRQLTMV1020
 1021 PKVAPPPPMR TSSTLTPQQQ QQQQQQFHHE ANLSNLSAMS SNTSISEDSC QTIITTCAQV1080
 1081 HSEQSPLKDL QMLVAQDELP LPPPMELPPY PSPPHSSCHS RQASEDFPPP PPPELDLEPL1140
 1141 NQQLSQLQAL EAASKQQRQQ LESLEGTTSI LAQLQQRQHL LKLRKEQANH PGAATTDATW1200
 1201 LKELQAKQAN DLRAMQRKLE ASSPSSVRDL THRFEQTSIR SYASQELLSQ PGQSQQLGQL1260
 1261 RTQMNGLPNG NAKMDVDEVD AMPAVRNSLP AALSAHQLLP KPKYEMTQSQ IAEEIREVEL1320
 1321 LNTMVQQTLN QNGAAALPKR VKKKSVSFCD QVILVATAGN EEDDDFIPNP ILERVLRTAQ1380
 1381 HPNEKVTAQM IQQQQQNMMR LQTEAQPRQQ QVQQLQQPSP MLGRPAGATA DMQRYVQRMQ1440
 1441 QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQHQELYRQ QQLHRTSMSG IASQQHLQQL1500
 1501 DAQYTTMPRP LHHSQLGSYS VTLQKHQQLQ QQQQQQQQQQ APQQLSLGYF SNGSVATSEQ1560
 1561 VPLPSPYQRV PLPHGYQPAA AGPYYPLPNA QQHLQQQQLM AKPVQKKVSF EPGTKGEADC1620
 1621 LPPPPPPPQK NGLPETGSAG SGHPGAAPGA SGAGGTTSAG ITAIPTRVYN NAIVKASAKA1680
 1681 VECNLCRKRH VIAPAVYCTN CEYYLQMLNQ RR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..415] FFAS03 3.1 Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)
    2 View Details [416..587] deduced N/A No confident structure predictions are available.
    3 View Details [588..777] deduced N/A No confident structure predictions are available.
    4 View Details [778..962] deduced N/A No confident structure predictions are available.
    5 View Details [963..1048] deduced N/A No confident structure predictions are available.
    6 View Details [1049..1402] PSI-BLAST 17.221849 Heavy meromyosin subfragment
    7 View Details [1403..1712] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  0.560349219089937 bayes_pls_golite062009
  • binding
    		•  0.1527582694371 bayes_pls_golite062009
  • protein binding
    		•  0.139172653049021 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle