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Protein Overview: Vmat-PD

General Information:
Name(s) found: Vmat-PD / FBpp0090962 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • The gene Vesicular monoamine transporter is referred to in FlyBase by the symbol Dmel\Vmat (CG33528, FBgn0260964). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9400632..9420494. It has the cytological map location 50B2-50B3. There is experimental evidence that it has the molecular function</span>: synaptic vesicle amine transmembrane transporter activity; monoamine transmembrane transporter activity. There is experimental evidence that it is involved in the biological process</span>: dopamine transport; monoamine transport; synaptic vesicle amine transport. 11 alleles are reported. The phenotypes of these alleles are annotated with: oocyte; larval neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 646 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [ISS]
    integral to membrane [ISS]
    neuromuscular junction [IDA]
    Biological Process: neurotransmitter transport [ISS]
    dopamine transport [IMP]
    transmembrane transport [IEA]
    monoamine transport [IDA]
    synaptic vesicle amine transport [IDA]
    Molecular Function: synaptic vesicle amine transmembrane transporter activity [IDA]
    monoamine transmembrane transporter activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSSTDAGNG GPRKHTQSTA PQKQSEISET TSFTVNANTT TNSQQQQIPG GPASNTPSKN  60
   61 PFKQQLDSNQ QNGNMEPDCG IMGVGKEPPV PPPPTYQSQT YAGRQAPPPA DQYREEDPRA 120
  121 AGSWAAAKSW MVSWRGSNRL VLVIVAIALL LDNMLLTTVV PIIPEFLYDI RHPDAPLDSF 180
  181 PRTPLTSNVP PPPTPCPCNK DGSEAAPLEI STISPEENET YYRELEERHN ELVGETVEVG 240
  241 LLFASKAFVQ LLVNPIVGPL THRIGYSIPM FAGFVIMFLS TIIFAFGRSY LVLFVARALQ 300
  301 GIGSSCSSVS GMGMLADRFT DDKERGNAMG IALGGLALGV LIGPPFGGVM YEFVGKSAPF 360
  361 LILAALALGD GLLQLFMLQP SIQKAETEPP SLKSLISDPY ILIAAGAITF ANMGIAMLEP 420
  421 SLPLWMVDNM GATRWEQGVA FLPASISYLI GTNLFGPLGH KIGRWFAACL GLIIIGGCLI 480
  481 FIPMATSITH LIIPNAGLGF AIGMVDSSMM PELGYLVDIR HSAVYGSVYA LGDVAFCVGF 540
  541 AVGPALSGSL VKSIGFEWML FGIAILCFMY APLLTLLKNP PTSDEKKVRM AREAAEAAAA 600
  601 AAAASGEFSG IPQMTASCPA IMHGASVPDS DAEAGRTNEA YESERL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] deduced N/A No confident structure predictions are available.
    2 View Details [188..646] PSI-BLAST 35.69897 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.24937104052238 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • binding
    		•  1.05701989682533 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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