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View Structure Prediction Details

Protein: egr-PA
Organism: Drosophila melanogaster
Length: 415 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for egr-PA.

Description E-value Query
Range
Subject
Range
egr-PB - The gene eiger is referred to in FlyBase by the symbol Dmel\egr (CG12919, FBgn0033483). It is a prot...
gi|220951926 - gi|220951926|gb|ACL88506.1| egr-PB [synthetic construct]
387.0 [0..1] [415..1]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAETLKPFI TPTSANDDGF PAKATSTATA QRRTRQLIPL VLGFIGLGLV VAILALTIWQ  60
   61 TTRVSHLDKE LKSLKRVVDN LQQRLGI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYLDEFDEFQ KEYENALIDY PKKVDGLTDE EDDDDGDGLD SIADDEDDDV SYSSVDDVGA  60
   61 DYEDYTDMLN KLNNAHTGTT PTSETTAEGE GETDSA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [184-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSASNDDNVF DDFTSYNAHK KKQERKSRSI ADVRNEEQNI QGNHTELQEK SSNEATSKES  60
   61 PAPLHHRRRM HSRHRHLLVR KGESLLSARS EDSRPAAHFH LSSRRRHQGS MGYHGDMYIG 120
  121 NDNERNSYQG HFQTRDGVLT VTNTGLYYVY AQICYNNSHD QNGFIVFQGD TPFLQCLNTV 180
  181 PTNMPHKVHT CHTSGLIHLE RNERIHLKDI HNDRNAVLRE GNNRSYFGIF KV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1osgA
Description: Soluble part of TALL-1, sTALL-1 (BAFF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.25413201891408 bayes_pls_golite062009
receptor binding 1.87082918048468 bayes_pls_golite062009
binding 1.55055236820725 bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding 1.47525106874221 bayes_pls_golite062009
CD40 receptor binding 0.275062817872213 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle