YRC Public Data Repository - Protein Structure Prediction

Protein:	LEMD1
Organism:	Homo sapiens
Length:	181 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEMD1.

Description	E-value	Query Range	Subject Range
gi\|114572111 - gi\|114572111\|ref\|XP_001161560.1\| PREDICTED: LEM domain containing 1 isoform 4 [Pan troglodytes]	3.0E-60	[1..181]	[1..181]
gi\|51494939 - gi\|51494939\|gb\|AAH36636.1\| LEMD1 protein [Homo sapiens]	9.0E-58	[1..181]	[1..181]
gi\|148238114, gi... - gi\|56849616\|gb\|AAN75632.2\|AF115498_1 Smad1 antagonistic effector [Xenopus laevis], gi\|148238114\|ref\|...	7.0E-44	[2..155]	[1..155]
LAP2B_MOUSE - Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma OS=Mus musculus GN=Tmpo PE=1 SV=3	4.0E-35	[2..144]	[109..257]
gi\|73977652 - gi\|73977652\|ref\|XP_866351.1\| PREDICTED: similar to Lamina-associated polypeptide 2, isoforms beta/ga...	4.0E-35	[2..144]	[110..258]
gi\|109098342 - gi\|109098342\|ref\|XP_001082220.1\| PREDICTED: thymopoietin isoform 1 [Macaca mulatta]	4.0E-35	[2..144]	[110..258]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDVKCLSDC KLQNQLEKLG FSPGPILPST RKLYEKKLVQ LLVSPPCAPP VMNGPRELDG  60
   61 AQDSDDSEEL NIILQGNIIL STEKSKKLKK WPEASTTKRK AVDTYCLDYK PS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.522879
Match:	1jeiA
Description:	Inner nuclear membrane protein emerin
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [113-181]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGRRWAARAP STRITYGTIT KERDYCAEDQ TIESWREEGF PVGLKLAVLG IFIIVVFVYL  60
   61 TVENKSLFG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits