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View Structure Prediction Details

Protein: LEMD1
Organism: Homo sapiens
Length: 181 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEMD1.

Description E-value Query
Range
Subject
Range
gi|114572111 - gi|114572111|ref|XP_001161560.1| PREDICTED: LEM domain containing 1 isoform 4 [Pan troglodytes]
3.0E-60 [1..181] [1..181]
gi|51494939 - gi|51494939|gb|AAH36636.1| LEMD1 protein [Homo sapiens]
9.0E-58 [1..181] [1..181]
gi|148238114, gi... - gi|56849616|gb|AAN75632.2|AF115498_1 Smad1 antagonistic effector [Xenopus laevis], gi|148238114|ref|...
7.0E-44 [2..155] [1..155]
LAP2B_MOUSE - Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma OS=Mus musculus GN=Tmpo PE=1 SV=3
4.0E-35 [2..144] [109..257]
gi|73977652 - gi|73977652|ref|XP_866351.1| PREDICTED: similar to Lamina-associated polypeptide 2, isoforms beta/ga...
4.0E-35 [2..144] [110..258]
gi|109098342 - gi|109098342|ref|XP_001082220.1| PREDICTED: thymopoietin isoform 1 [Macaca mulatta]
4.0E-35 [2..144] [110..258]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDVKCLSDC KLQNQLEKLG FSPGPILPST RKLYEKKLVQ LLVSPPCAPP VMNGPRELDG  60
   61 AQDSDDSEEL NIILQGNIIL STEKSKKLKK WPEASTTKRK AVDTYCLDYK PS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1jeiA
Description: Inner nuclear membrane protein emerin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [113-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGRRWAARAP STRITYGTIT KERDYCAEDQ TIESWREEGF PVGLKLAVLG IFIIVVFVYL  60
   61 TVENKSLFG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.526 N/A N/A c.51.3 B12-dependend dehydatases associated subunit
View Download 0.505 N/A N/A b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.475 N/A N/A b.55.1 PH domain-like
View Download 0.405 N/A N/A d.93.1 SH2 domain
View Download 0.383 N/A N/A b.55.1 PH domain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle