YRC Public Data Repository - Protein Structure Prediction

Protein:	C9orf72
Organism:	Homo sapiens
Length:	481 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C9orf72.

Description	E-value	Query Range	Subject Range
gi\|123229922, gi... - gi\|94373145\|ref\|XP_986526.1\| PREDICTED: similar to Protein C9orf72 homolog isoform 4 [Mus musculus],...	0.0	[1..481]	[1..481]
CI072_RAT - Protein C9orf72 homolog OS=Rattus norvegicus PE=2 SV=1	0.0	[1..481]	[1..481]
gi\|114624009, gi... - gi\|114624009\|ref\|XP_001155133.1\| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes], gi\|114...	0.0	[1..481]	[1..481]
CCDS6522.1_1 - null gi\|109111311 - gi\|109111311\|ref\|XP_001104667.1\| PREDICTED: similar to Protein C9orf72 homolog [Macaca mulatta]	0.0	[1..481]	[1..481]
gi\|156718106, gi... - gi\|76624134\|ref\|XP_869915.1\| PREDICTED: similar to Protein C9orf72 homolog isoform 2 [Bos taurus], g...	0.0	[1..481]	[1..481]
gi\|73971093, gi\|... - gi\|73971099\|ref\|XP_538691.2\| PREDICTED: similar to Protein C9orf72 homolog isoform 1 [Canis familiar...	0.0	[1..481]	[1..481]
gi\|220679138, gi... - gi\|45387633\|ref\|NP_991166.1\| hypothetical protein LOC402895 [Danio rerio], gi\|37595336\|gb\|AAQ94554.1...	0.0	[1..481]	[1..462]

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Predicted Domain #1

Region A:
Residues: [1-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLCPPPSP AVAKTEIALS GKSPLLAATF AYWDNILGPR VRHIWAPKTE QVLLSDGEIT  60
   61 FLANHTLNGE ILRNAE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [77-169]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGAIDVKFFV LSEKGVIIVS LIFDGNWNGD RSTYGLSIIL PQTELSFYLP LHRVCVDRLT  60
   61 HIIRKGRIWM HKERQENVQK IILEGTERME DQG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [170-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSIIPMLTGE VIPVMELLSS MKSHSVPEEI DIADTVLNDD DIGDSCHEGF LLNAISSHLQ  60
   61 TCGCSVVVGS SAEKVNKIVR TLCLFLTPAE RKCSRLCEAE SSFKYESGLF VQGLLKDSTG 120
  121 SFVLPFRQVM YAPYPTTHID VDVNTVK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [317-481]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMPPCHEHIY NQRRYMRSEL TAFWRATSEE DMAQDTIIYT DESFTPDLNI FQDVLHRDTL  60
   61 VKAFLDQVFQ LKPGLSLRST FLAQFLLVLH RKALTLIKYI EDDTQKGKKP FKSLRNLKID 120
  121 LDLTAEGDLN IIMALAEKIK PGLHSFIFGR PFYTSVQERD VLMTF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits