YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|54673670, gi\|...
Organism:	Homo sapiens
Length:	384 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|54673670, gi|....

Description	E-value	Query Range	Subject Range
gi\|114645198 - gi\|114645198\|ref\|XP_001165727.1\| PREDICTED: twinfilin isoform 5 [Pan troglodytes]	0.0	[1..384]	[1..384]
gi\|46329883 - gi\|46329883\|gb\|AAH68548.1\| TWF1 protein [Homo sapiens]	0.0	[13..384]	[1..372]
gi\|61368434, gi\|... - gi\|61368434\|gb\|AAX43179.1\| PTK9 protein tyrosine kinase 9 [synthetic construct], gi\|60828062\|gb\|AAX3...	0.0	[35..384]	[1..350]
gi\|117616766 - gi\|117616766\|gb\|ABK42401.1\| A6 [synthetic construct] TWF1_MOUSE - Twinfilin-1 OS=Mus musculus GN=Twf1 PE=1 SV=2	0.0	[35..384]	[1..350]
TWF1_PONAB - Twinfilin-1 OS=Pongo abelii GN=TWF1 PE=2 SV=1 TWF1_PONPY - Twinfilin-1 - Pongo pygmaeus (Orangutan)	0.0	[35..384]	[1..350]

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Predicted Domain #1

Region A:
Residues: [1-199]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRRGRRRSS HFLGPPAGAA GCTQRRSREL AAAAMSHQTG IQASEDVKEI FARARNGKYR  60
   61 LLKISIENEQ LVIGSYSQPS DSWDKDYDSF VLPLLEDKQP CYILFRLDSQ NAQGYEWIFI 120
  121 AWSPDHSHVR QKMLYAATRA TLKKEFGGGH IKDEVFGTVK EDVSLHGYKK YLLSQSSPAP 180
  181 LTAAEEELRQ IKINEVQTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.0
Match:	1m4jA
Description:	Adf-H domain of twinfilin isoform-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	7.52071741004022	bayes_pls_golite062009
cytoskeletal protein binding	6.04859625643932	bayes_pls_golite062009
actin filament binding	5.45532510538573	bayes_pls_golite062009
binding	2.41877859618486	bayes_pls_golite062009
protein kinase activity	2.22634235673758	bayes_pls_golite062009
protein binding	1.87981807141519	bayes_pls_golite062009
protein tyrosine kinase activity	1.87091423399482	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.67227267699496	bayes_pls_golite062009
kinase activity	1.55883505515498	bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding	1.3406661967545	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.30213296029859	bayes_pls_golite062009
molecular transducer activity	1.14209355225632	bayes_pls_golite062009
signal transducer activity	1.14209355225632	bayes_pls_golite062009
transferase activity	0.591259446255369	bayes_pls_golite062009
structural constituent of cytoskeleton	0.482954032096802	bayes_pls_golite062009
structural molecule activity	0.391701411061931	bayes_pls_golite062009
actin monomer binding	0.224304003054399	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [200-384]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGVDTKHQTL QGVAFPISRE AFQALEKLNN RQLNYVQLEI DIKNEIIILA NTTNTELKDL  60
   61 PKRIPKDSAR YHFFLYKHSH EGDYLESIVF IYSMPGYTCS IRERMLYSSC KSRLLEIVER 120
  121 QLQMDVIRKI EIDNGDELTA DFLYEEVHPK QHAHKQSFAK PKGPAGKRGI RRLIRGPAET 180
  181 EATTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.30103
Match:	2d8bA
Description:	No description for 2d8bA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: