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View Structure Prediction Details

Protein: GGA2
Organism: Homo sapiens
Length: 613 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GGA2.

Description E-value Query
Range
Subject
Range
gi|123983479, gi... - gi|168273152|dbj|BAG10415.1| ADP-ribosylation factor-binding protein GGA2 [synthetic construct], gi|...
GGA2 - golgi-associated, gamma adaptin ear containing, ARF binding protein 2
0.0 [1..613] [1..613]
gi|114661580 - gi|114661580|ref|XP_001162100.1| PREDICTED: ADP-ribosylation factor binding protein 2 isoform 2 [Pan...
0.0 [1..613] [1..613]
gi|213688377, gi... - gi|213688377|ref|NP_001093989.1| golgi associated, gamma adaptin ear containing, ARF binding protein...
0.0 [9..613] [12..604]
gi|73958741 - gi|73958741|ref|XP_850701.1| PREDICTED: similar to ADP-ribosylation factor binding protein GGA2 (Gol...
0.0 [31..613] [2..584]
gi|37360224 - gi|37360224|dbj|BAC98090.1| mKIAA1080 protein [Mus musculus]
0.0 [9..613] [21..612]

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Predicted Domain #1
Region A:
Residues: [1-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC EQVNTDPNGP  60
   61 THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE VAKFRFLNEL IKVLSPKYLG 120
  121 SWATGKVKGR VIEILFSWTV WFPEDIKIRD AYQMLKKQG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1mhqA
Description: ADP-ribosylation factor binding protein Gga2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ADP-ribosylation factor binding 3.85762908083934 bayes_pls_golite062009
clathrin binding 3.30137505848907 bayes_pls_golite062009
protein binding 2.16467447169895 bayes_pls_golite062009
binding 2.0426788146333 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [160-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIKQDPKLPV DKILPPPSPW PKSSIFDADE EKSKLLTRLL KSNHPEDLQA ANRLIKNLVK  60
   61 EEQEKSEKVS KRVSAVEEVR SHVKVLQEML SMYRRPGQAP PDQEALQVVY ERCEKLRPTL 120
  121 FRLASDTTDD DDALAEILQA NDLLTQGVLL YKQVMEGRVT FGNRVTSSLG DIPVSRVFQN 180
  181 PAGCMKTCPL IDLEVDNGPA QMGTVVPSLL HQDLAALGIS DAPVTGMVSG Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 1oxzA
Description: ADP-ribosylation factor binding protein Gga1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 4.81261479432124 bayes_pls_golite062009
protein binding 1.957004610117 bayes_pls_golite062009
binding 1.91194387645876 bayes_pls_golite062009
phosphoinositide binding 0.45587067774604 bayes_pls_golite062009
phospholipid binding 0.17195722324229 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [391-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NCCEEKRNPS SSTLPGGGVQ NPSADRNLLD LLSAQPAPCP LNYVSQKSVP KEVPPGTKSS  60
   61 PGWSWEAGPL APSPSSQNTP LAQVFVPLES VKPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [485-613]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLPPLIVYDR NGFRILLHFS QTGAPGHPEV QVLLLTMMST APQPVWDIMF QVAVPKSMRV  60
   61 KLQPASSSKL PAFSPLMPPA VISQMLLLDN PHKEPIRLRY KLTFNQGGQP FSEVGEVKDF 120
  121 PDLAVLGAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.39794
Match: 1om9A
Description: ADP-ribosylation factor binding protein Gga1 domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.57801165255065 bayes_pls_golite062009
binding 1.4853299341494 bayes_pls_golite062009
transporter activity 0.169557557237959 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle