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View Structure Prediction Details

Protein: GGA2
Organism: Homo sapiens
Length: 613 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GGA2.

Description E-value Query
Range
Subject
Range
gi|123983479, gi... - gi|168273152|dbj|BAG10415.1| ADP-ribosylation factor-binding protein GGA2 [synthetic construct], gi|...
GGA2 - golgi-associated, gamma adaptin ear containing, ARF binding protein 2
0.0 [1..613] [1..613]
gi|114661580 - gi|114661580|ref|XP_001162100.1| PREDICTED: ADP-ribosylation factor binding protein 2 isoform 2 [Pan...
0.0 [1..613] [1..613]
gi|213688377, gi... - gi|213688377|ref|NP_001093989.1| golgi associated, gamma adaptin ear containing, ARF binding protein...
0.0 [9..613] [12..604]
gi|73958741 - gi|73958741|ref|XP_850701.1| PREDICTED: similar to ADP-ribosylation factor binding protein GGA2 (Gol...
0.0 [31..613] [2..584]
gi|37360224 - gi|37360224|dbj|BAC98090.1| mKIAA1080 protein [Mus musculus]
0.0 [9..613] [21..612]

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Predicted Domain #1
Region A:
Residues: [1-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC EQVNTDPNGP  60
   61 THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE VAKFRFLNEL IKVLSPKYLG 120
  121 SWATGKVKGR VIEILFSWTV WFPEDIKIRD AYQMLKKQG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 1mhqA
Description: ADP-ribosylation factor binding protein Gga2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ADP-ribosylation factor binding 3.85762908083934 bayes_pls_golite062009
clathrin binding 3.30137505848907 bayes_pls_golite062009
protein binding 2.16467447169895 bayes_pls_golite062009
binding 2.0426788146333 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [160-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIKQDPKLPV DKILPPPSPW PKSSIFDADE EKSKLLTRLL KSNHPEDLQA ANRLIKNLVK  60
   61 EEQEKSEKVS KRVSAVEEVR SHVKVLQEML SMYRRPGQAP PDQEALQVVY ERCEKLRPTL 120
  121 FRLASDTTDD DDALAEILQA NDLLTQGVLL YKQVMEGRVT FGNRVTSSLG DIPVSRVFQN 180
  181 PAGCMKTCPL IDLEVDNGPA QMGTVVPSLL HQDLAALGIS DAPVTGMVSG Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.0
Match: 1oxzA
Description: ADP-ribosylation factor binding protein Gga1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 4.81261479432124 bayes_pls_golite062009
protein binding 1.957004610117 bayes_pls_golite062009
binding 1.91194387645876 bayes_pls_golite062009
phosphoinositide binding 0.45587067774604 bayes_pls_golite062009
phospholipid binding 0.17195722324229 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [391-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NCCEEKRNPS SSTLPGGGVQ NPSADRNLLD LLSAQPAPCP LNYVSQKSVP KEVPPGTKSS  60
   61 PGWSWEAGPL APSPSSQNTP LAQVFVPLES VKPS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [485-613]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLPPLIVYDR NGFRILLHFS QTGAPGHPEV QVLLLTMMST APQPVWDIMF QVAVPKSMRV  60
   61 KLQPASSSKL PAFSPLMPPA VISQMLLLDN PHKEPIRLRY KLTFNQGGQP FSEVGEVKDF 120
  121 PDLAVLGAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.39794
Match: 1om9A
Description: ADP-ribosylation factor binding protein Gga1 domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.57801165255065 bayes_pls_golite062009
binding 1.4853299341494 bayes_pls_golite062009
transporter activity 0.169557557237959 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle