YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|2506080, gi\|4...
Organism:	Homo sapiens
Length:	1311 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|2506080, gi|4....

Description	E-value	Query Range	Subject Range
GAK - cyclin G associated kinase	1095.0	[0..1]	[1311..1]
gi\|114592749 - gi\|114592749\|ref\|XP_001140835.1\| PREDICTED: cyclin G associated kinase isoform 9 [Pan troglodytes]	1092.0	[0..1]	[1311..1]
gi\|197102832 - gi\|197102832\|ref\|NP_001125100.1\| cyclin G associated kinase [Pongo abelii] gi\|55726958 - gi\|55726958\|emb\|CAH90237.1\| hypothetical protein [Pongo abelii]	1086.0	[0..1]	[1311..1]
gi\|51317387, gi\|... - gi\|74177683\|dbj\|BAE38941.1\| unnamed protein product [Mus musculus], gi\|51317387\|ref\|NP_705797.1\| cyc...	1061.0	[0..1]	[1311..1]
GAK_RAT - Cyclin-G-associated kinase OS=Rattus norvegicus GN=Gak PE=1 SV=1	1040.0	[0..1]	[1311..1]

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Predicted Domain #1

Region A:
Residues: [1-380]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV  60
   61 GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120
  121 LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180
  181 LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI 240
  241 GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 300
  301 EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG 360
  361 GLALAEYDQP YGGFLDILRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.69897
Match:	1zmuA
Description:	Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [381-510]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM SFPAEGVESA LKNNIEDVRL  60
   61 FLDSKHPGHY AVYNLSPRTY RPSRFHNRVS ECGWAARRAP HLHTLYNICR NMHAWLRQDH 120
  121 KNVCVVHCMD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.69897
Match:	2p6xA
Description:	No description for 2p6xA was found.

Predicted Domain #3

Region A:
Residues: [511-712]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRAASAVAVC SFLCFCRLFS TAEAAVYMFS MKRCPPGIWP SHKRYIEYMC DMVAEEPITP  60
   61 HSKPILVRAV VMTPVPLFSK QRSGCRPFCE VYVGDERVAS TSQEYDKMRD FKIEDGKAVI 120
  121 PLGVTVQGDV LIVIYHARST LGGRLQAKMA SMKMFQIQFH TGFVPRNATT VKFAKYDLDA 180
  181 CDIQEKYPDL FQVNLEVEVE PR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.522879
Match:	1d5rA
Description:	Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [713-1219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRPSREAPPW ENSSMRGLNP KILFSSREEQ QDILSKFGKP ELPRQPGSTA QYDAGAGSPE  60
   61 AEPTDSDSPP SSSADASRFL HTLDWQEEKE AETGAENASS KESESALMED RDESEVSDEG 120
  121 GSPISSEGQE PRADPEPPGL AAGLVQQDLV FEVETPAVLP EPVPQEDGVD LLGLHSEVGA 180
  181 GPAVPPQACK APSSNTDLLS CLLGPPEAAS QGPPEDLLSE DPLLLASPAP PLSVQSTPRG 240
  241 GPPAAADPFG PLLPSSGNNS QPCSNPDLFG EFLNSDSVTV PPSFPSAHSA PPPSCSADFL 300
  301 HLGDLPGEPS KMTASSSNPD LLGGWAAWTE TAASAVAPTP ATEGPLFSPG GQPAPCGSQA 360
  361 SWTKSQNPDP FADLGDLSSG LQGSPAGFPP GGFIPKTATT AKGSSSWQTS RPPAQGASWP 420
  421 PQAKPPPKAC TQPRPNYASN FSVIGAREER GVRAPSFAQK PKVSENDFED LLSNQGFSSR 480
  481 SDKKGPKTIA EMRKQDLAKD TDPLKLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.39794
Match:	1y0fA
Description:	No description for 1y0fA was found.

Predicted Domain #5

Region A:
Residues: [1220-1311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLDWIEGKER NIRALLSTLH TVLWDGESRW TPVGMADLVA PEQVKKHYRR AVLAVHPDKA  60
   61 AGQPYEQHAK MIFMELNDAW SEFENQGSRP LF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.522879
Match:	1n4cA
Description:	NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits