YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24797151
Organism:	Homo sapiens
Length:	866 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24797151.

Description	E-value	Query Range	Subject Range
DMGDH - dimethylglycine dehydrogenase	0.0	[1..866]	[1..866]
gi\|114599496 - gi\|114599496\|ref\|XP_526883.2\| PREDICTED: dimethylglycine dehydrogenase isoform 2 [Pan troglodytes]	0.0	[1..866]	[1..866]
M2GD_MOUSE - Dimethylglycine dehydrogenase, mitochondrial OS=Mus musculus GN=Dmgdh PE=1 SV=1	0.0	[1..863]	[1..856]
M2GD_RAT - Dimethylglycine dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Dmgdh PE=1 SV=1	0.0	[1..863]	[1..856]
gi\|76626460 - gi\|76626460\|ref\|XP_580581.2\| PREDICTED: similar to Dimethylglycine dehydrogenase, mitochondrial prec...	0.0	[1..860]	[1..860]
gi\|148228313, gi... - gi\|86577798\|gb\|AAI12956.1\| LOC446949 protein [Xenopus laevis], gi\|148228313\|ref\|NP_001087085.1\| hypo...	0.0	[16..862]	[20..869]
gi\|73952357 - gi\|73952357\|ref\|XP_546052.2\| PREDICTED: similar to Dimethylglycine dehydrogenase, mitochondrial prec...	0.0	[4..865]	[11..874]
gi\|50755286 - gi\|50755286\|ref\|XP_414684.1\| PREDICTED: similar to Dimethylglycine dehydrogenase, mitochondrial prec...	0.0	[93..865]	[14..786]

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Predicted Domain #1

Region A:
Residues: [1-866]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRPGAQLLR GLLLRSCPLQ GSPGRPRSVC GREGEEKPPL SAETQWKDRA ETVIIGGGCV  60
   61 GVSLAYHLAK AGMKDVVLLE KSELTAGSTW HAAGLTTYFH PGINLKKIHY DSIKLYEKLE 120
  121 EETGQVVGFH QPGSIRLATT PVRVDEFKYQ MTRTGWHATE QYLIEPEKIQ EMFPLLNMNK 180
  181 VLAGLYNPGD GHIDPYSLTM ALAAGARKCG ALLKYPAPVT SLKARSDGTW DVETPQGSMR 240
  241 ANRIVNAAGF WAREVGKMIG LEHPLIPVQH QYVVTSTISE VKALKRELPV LRDLEGSYYL 300
  301 RQERDGLLFG PYESQEKMKV QDSWVTNGVP PGFGKELFES DLDRIMEHIK AAMEMVPVLK 360
  361 KADIINVVNG PITYSPDILP MVGPHQGVRN YWVAIGFGYG IIHAGGVGKY LSDWILHGEP 420
  421 PFDLIELDPN RYGKWTTTQY TEAKARESYG FNNIVGYPKE ERFAGRPTQR VSGLYQRLES 480
  481 KCSMGFHAGW EQPHWFYKPG QDTQYRPSFR RTNWFEPVGS EYKQVMQRVA VTDLSPFGKF 540
  541 NIKGQDSIRL LDHLFANVIP KVGFTNISHM LTPKGRVYAE LTVSHQSPGE FLLITGSGSE 600
  601 LHDLRWIEEE AVKGGYDVEI KNITDELGVL GVAGPQARKV LQKLTSEDLS DDVFKFLQTK 660
  661 SLKVSNIPVT AIRISYTGEL GWELYHRRED SVALYDAIMN AGQEEGIDNF GTYAMNALRL 720
  721 EKAFRAWGLE MNCDTNPLEA GLEYFVKLNK PADFIGKQAL KQIKAKGLKR RLVCLTLATD 780
  781 DVDPEGNESI WYNGKVVGNT TSGSYSYSIQ KSLAFAYVPV QLSEVGQQVE VELLGKNYPA 840
  841 VIIQEPLVLT EPTRNRLQKK GGKDKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	142.0
Match:	1pj5A
Description:	Crystal structure of dimethylglycine oxidase of Arthrobacter globiformis in complex with acetate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aminomethyltransferase activity	10.5654741349554	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	5.37200252580633	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	5.37200252580633	bayes_pls_golite062009
choline dehydrogenase activity	3.17551571315937	bayes_pls_golite062009
sarcosine dehydrogenase activity	3.16989177210403	bayes_pls_golite062009
dimethylglycine dehydrogenase activity	2.89047185292175	bayes_pls_golite062009
methyltransferase activity	2.70138650934058	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	2.61988251128991	bayes_pls_golite062009
catalytic activity	1.65079399897053	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.61125987248836	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.48681373014973	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	1.24564487540873	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	1.19783690850993	bayes_pls_golite062009
oxidoreductase activity	0.867567984371732	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors	0.550291785460228	bayes_pls_golite062009
transferase activity	0.217873555384951	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.170082356807927	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: