YRC Public Data Repository - Protein Structure Prediction

Protein:	RSUA_ECOLI
Organism:	Escherichia coli
Length:	231 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RSUA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110806162, gi... - gi\|110806162\|ref\|YP_689682.1\| 16S rRNA pseudouridylate synthase A [Shigella flexneri 5 str. 8401], g... gi\|91211473, gi\|... - gi\|91211473\|ref\|YP_541459.1\| ribosomal small subunit pseudouridine synthase A [Escherichia coli UTI8... gi\|26248566, gi\|... - gi\|26248566\|ref\|NP_754606.1\| Ribosomal small subunit pseudouridine synthase A [Escherichia coli CFT0...	240.0	[0..1]	[231..33]
gi\|193068120, gi... - gi\|75237979\|ref\|ZP_00721984.1\| COG1187: 16S rRNA uridine-516 pseudouridylate synthase and related ps...	240.0	[0..1]	[231..1]
gi\|187430576, gi... - gi\|75176196\|ref\|ZP_00696354.1\| COG1187: 16S rRNA uridine-516 pseudouridylate synthase and related ps...	240.0	[0..1]	[231..1]
gi\|74312704, gi\|... - gi\|74312704\|ref\|YP_311123.1\| 16S rRNA pseudouridylate synthase A [Shigella sonnei Ss046], gi\|7385618...	239.0	[0..1]	[231..1]
gi\|52306498, gi\|... - gi\|52424446\|ref\|YP_087583.1\| RsuA protein [Mannheimia succiniciproducens MBEL55E], gi\|52306498\|gb\|AA...	238.0	[0..1]	[229..17]
gi\|81240362, gi\|... - gi\|82776214\|ref\|YP_402563.1\| 16S rRNA pseudouridylate synthase A [Shigella dysenteriae Sd197], gi\|81...	238.0	[0..1]	[231..1]
gi\|220931567, gi... - gi\|89211767\|ref\|ZP_01190111.1\| Pseudouridine synthase, Rsu [Halothermothrix orenii H 168], gi\|891586...	236.0	[0..2]	[230..3]
gi\|77976694, gi\|... - gi\|77976694\|ref\|ZP_00832169.1\| COG1187: 16S rRNA uridine-516 pseudouridylate synthase and related ps...	236.0	[0..1]	[230..1]
gi\|39983385, gi\|... - gi\|39996504\|ref\|NP_952455.1\| ribosomal large subunit pseudouridine synthase B [Geobacter sulfurreduc...	236.0	[0..2]	[230..4]
gi\|238796852, gi... - gi\|77962648\|ref\|ZP_00826466.1\| COG1187: 16S rRNA uridine-516 pseudouridylate synthase and related ps...	234.0	[0..1]	[230..1]

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Predicted Domain #1

Region A:
Residues: [1-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLDKFIAQQ LGVSRAIAGR EIRGNRVTVD GEIVRNAAFK LLPEHDVAYD GNPLAQQHGP  60
   61 RYFMLNKPQG YVCSTDDPDH PTVLYFLDEP VAWKLHAAGR LDIDTTGLVL MTDDGQWSHR 120
  121 ITSPRHHCEK TYLVTLESPV ADDTAEQFAK GVQLHNEKDL TKPAVLEVIT PTQVRLTISE 180
  181 GRYHQVKRMF AAVGNHVVEL HRERIGGITL DADLAPGEYR PLTEEEIASV V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.69897
Match:	1kskA
Description:	Ribosomal small subunit pseudouridine 516 synthase RsuA; Pseudouridine synthase RsuA N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	5.60483019625575	bayes_pls_golite062009
intramolecular transferase activity	4.62815459483632	bayes_pls_golite062009
isomerase activity	3.43067391737824	bayes_pls_golite062009
catalytic activity	2.39224964671205	bayes_pls_golite062009
structural constituent of ribosome	1.93805098366683	bayes_pls_golite062009
structural molecule activity	1.65902435754631	bayes_pls_golite062009
RNA binding	0.351909066993469	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: