YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRDA_LACLC
Organism:	Lactococcus lactis subsp. cremoris
Length:	311 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRDA_LACLC.

Description	E-value	Query Range	Subject Range
PYRD_NOSP7 - Dihydroorotate dehydrogenase (quinone) OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=pyrD...	249.0	[0..2]	[306..57]
PYRDA_LACLA, PYD... - Dihydroorotate dehydrogenase A OS=Lactococcus lactis subsp. lactis GN=pyrDA PE=3 SV=1, (Q9CFC9) Dihy... PYRDA_LACLA - Dihydroorotate dehydrogenase A (fumarate) OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=pyr...	245.0	[0..1]	[311..1]
gi\|33302309 - gi\|33302309\|gb\|AAQ01775.1\| dihydroorotate dehydrogenase 1a [Lactococcus lactis subsp. hordniae]	244.0	[0..1]	[311..1]
gi\|34809591, gi\|... - gi\|34809591\|pdb\|1JQV\|B Chain B, The K213e Mutant Of Lactococcus Lactis Dihydroorotate Dehydrogenase ...	243.0	[0..1]	[311..1]
gi\|116512347, gi... - gi\|62464151\|ref\|ZP_00383450.1\| COG0167: Dihydroorotate dehydrogenase [Lactococcus lactis subsp. crem...	243.0	[0..1]	[311..1]
PYRD_SACCA - Dihydroorotate dehydrogenase OS=Saccharomyces castellii GN=URA1 PE=3 SV=1 PYRD_NAUCC - Dihydroorotate dehydrogenase (fumarate) OS=Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBR...	242.0	[0..2]	[311..5]

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Predicted Domain #1

Region A:
Residues: [1-311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNTTFANAK FANPFMNASG VHCMTIEDLE ELKASQAGAY ITKSSTLEKR EGNPLPRYVD  60
   61 LELGSINSMG LPNLGFDYYL DYVLKNQKEN AQEGPIFFSI AGMSAAENIA MLKKIQESDF 120
  121 SGITELNLSC PNVPGKPQLA YDFEATEKLL KEVFTFFTKP LGVKLPPYFD LVHFDIMAEI 180
  181 LNQFPLTYVN SVNSIGNGLF IDPEAESVVI KPKDGFGGIG GAYIKPTALA NVRAFYTRLK 240
  241 PEIQIIGTGG IETGQDAFEH LLCGATMLQI GTALHKEGPA IFDRIIKELE EIMNQKGYQS 300
  301 IADFHGKLKS L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.39794
Match:	1dorA
Description:	Dihydroorotate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydroorotate dehydrogenase activity	2.73800716363956	bayes_pls_golite062009
dihydroorotate oxidase activity	2.35584458985229	bayes_pls_golite062009
catalytic activity	1.94749091175302	bayes_pls_golite062009
dihydropyrimidine dehydrogenase (NADP+) activity	1.76080169529176	bayes_pls_golite062009
oxidoreductase activity	1.34004057547793	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	0.708198550325532	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: