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View Structure Prediction Details

Protein: PFN1
Organism: Homo sapiens
Length: 139 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFN1.

Description E-value Query
Range		 Subject
Range
PROF2_RAT - Profilin-2 OS=Rattus norvegicus GN=Pfn2 PE=1 SV=3
 187.0 [0..1] [139..2]
gi|76675933 - gi|76675933|ref|XP_878544.1| PREDICTED: similar to profilin 2 isoform b isoform 2 [Bos taurus]
 186.0 [0..1] [136..2]
PROF2_MOUSE - Profilin-2 OS=Mus musculus GN=Pfn2 PE=1 SV=3
PROF2_BOVIN - Profilin-2 OS=Bos taurus GN=PFN2 PE=1 SV=2
 184.0 [0..1] [139..2]
gi|47207181 - gi|47207181|emb|CAF92165.1| unnamed protein product [Tetraodon nigroviridis]
 184.0 [0..3] [139..3]
PROF2_PONPY - Profilin-2 - Pongo pygmaeus (Orangutan)
PROF2_MACFA - Profilin-2 OS=Macaca fascicularis GN=PFN2 PE=2 SV=1
ENSMMUT000000328... - null, null
gi|208967134 - gi|208967134|dbj|BAG73581.1| profilin 2 [synthetic construct]
PFN2 - profilin 2
PROF2_PONAB - Profilin-2 OS=Pongo abelii GN=PFN2 PE=2 SV=3
ENSPTRT00000028967 - null
CCDS3148.1_1 - null
 184.0 [0..1] [139..2]
gi|119331154, gi... - gi|53130428|emb|CAG31543.1| hypothetical protein [Gallus gallus], gi|119331154|ref|NP_001073228.1| p...
 184.0 [0..1] [139..2]

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Predicted Domain #1
Region A:
Residues: [1-139] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGWNAYIDNL MADGTCQDAA IVGYKDSPSV WAAVPGKTFV NITPAEVGVL VGKDRSSFYV  60
   61 NGLTLGGQKC SVIRDSLLQD GEFSMDLRTK STGGAPTFNV TVTKTDKTLV LLMGKEGVHG 120
  121 GLINKKCYEM ASHLRRSQY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.0
Match: 1hluP
Description: Profilin (actin-binding protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.981958446142 bayes_pls_golite062009
cytoskeletal protein binding 6.51470611165788 bayes_pls_golite062009
actin monomer binding 3.80837480536839 bayes_pls_golite062009
binding 3.26636517628678 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 3.08913463974786 bayes_pls_golite062009
protein binding 2.14534188091242 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle