YRC Public Data Repository - Protein Structure Prediction

Protein:	PHOP_ECOLI
Organism:	Escherichia coli
Length:	223 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHOP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|10175779, gi\|... - gi\|15615719\|ref\|NP_244023.1\| two-component response regulator involved in phosphate regulation [Baci... gi\|25300880 - pir\|\|E84044 two-component response regulator involved in phosphate regulation phoP [imported] - Baci...	253.0	[0..2]	[222..4]
gi\|98660701 - gi\|98660701\|dbj\|GAA02123.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	249.0	[0..2]	[222..106]
gi\|56910719, gi\|... - gi\|56964476\|ref\|YP_176207.1\| two-component response regulator of alkaline phosphatase synthesis [Bac...	248.0	[0..2]	[222..4]
gi\|91201265 - gi\|91201265\|emb\|CAJ74325.1\| strongly similar to two-component response regulator OmpR/PhoB family [C...	248.0	[0..1]	[223..1]
gi\|82402957, gi\|... - gi\|82499061\|ref\|ZP_00884513.1\| Response regulator receiver [Caldicellulosiruptor saccharolyticus DSM...	248.0	[0..1]	[221..1]
gi\|48860348, gi\|... - gi\|67873291\|ref\|ZP_00503570.1\| Response regulator receiver:Transcriptional regulatory protein, C ter...	248.0	[0..2]	[223..6]
gi\|89084904, gi\|... - gi\|89100385\|ref\|ZP_01173249.1\| PhoP [Bacillus sp. NRRL B-14911], gi\|89084904\|gb\|EAR64041.1\| PhoP [Ba...	247.0	[0..2]	[222..4]
gi\|114566483, gi... - gi\|114566483\|ref\|YP_753637.1\| response regulator receiver protein [Syntrophomonas wolfei subsp. wolf...	246.0	[0..2]	[222..5]
gi\|4982229, gi\|1... - gi\|4982229\|gb\|AAD36722.1\|AE001807_13 response regulator DrrA [Thermotoga maritima MSB8], gi\|15644403... gi\|7444020 - pir\|\|D72228 response regulator DrrA - Thermotoga maritima (strain MSB8)	245.0	[0..2]	[221..13]

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Predicted Domain #1

Region A:
Residues: [1-121]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVLVVEDNA LLRHHLKVQI QDAGHQVDDA EDAKEADYYL NEHIPDIAIV DLGLPDEDGL  60
   61 SLIRRWRSND VSLPILVLTA RESWQDKVEV LSAGADDYVT KPFHIEEVMA RMQALMRRNS 120
  121 G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.0
Match:	2pkxA
Description:	No description for 2pkxA was found.

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	7.02872640261738	bayes_pls_golite062009
transcription regulator activity	5.23016166796951	bayes_pls_golite062009
signal transducer activity	4.51666042720644	bayes_pls_golite062009
molecular transducer activity	4.51666042720644	bayes_pls_golite062009
DNA binding	2.75354350283069	bayes_pls_golite062009
nucleic acid binding	2.67056525675208	bayes_pls_golite062009
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
transcription factor activity	2.12579037300919	bayes_pls_golite062009
binding	1.22427537074115	bayes_pls_golite062009
protein kinase activity	1.00737355751913	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.811771244977462	bayes_pls_golite062009
kinase activity	0.725824770559857	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.476057209677045	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [122-223]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LASQVISLPP FQVDLSRREL SINDEVIKLT AFEYTIMETL IRNNGKVVSK DSLMLQLYPD  60
   61 AELRESHTID VLMGRLRKKI QAQYPQEVIT TVRGQGYLFE LR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.0
Match:	2d1vA
Description:	No description for 2d1vA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: