YRC Public Data Repository - Protein Structure Prediction

Protein:	PEPE_ECOLI
Organism:	Escherichia coli
Length:	229 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEPE_ECOLI.

Description	E-value	Query Range	Subject Range
PEPE_HAEI8 - Peptidase E OS=Haemophilus influenzae (strain 86-028NP) GN=pepE PE=3 SV=1	186.0	[0..2]	[229..3]
gi\|46128830 - gi\|46128830\|ref\|ZP_00154337.2\| COG3340: Peptidase E [Haemophilus influenzae R2846]	185.0	[0..3]	[229..1]
gi\|53733345 - gi\|53733345\|ref\|ZP_00156410.2\| COG3340: Peptidase E [Haemophilus influenzae R2866] gi\|145638495, gi... - gi\|145638495\|ref\|ZP_01794104.1\| peptidase E [Haemophilus influenzae PittII], gi\|145272090\|gb\|EDK1199...	184.0	[0..2]	[229..3]
PEPE_SHEDO - Peptidase E OS=Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) GN=pepE PE=3 SV=1	184.0	[0..1]	[228..3]
gi\|73539362, gi\|... - gi\|73539362\|ref\|YP_299729.1\| peptidase E [Ralstonia eutropha JMP134], gi\|72122699\|gb\|AAZ64885.1\| alp...	181.0	[0..2]	[229..4]
gi\|69166032, gi\|... - gi\|69950351\|ref\|ZP_00638250.1\| Dipeptidase E [Shewanella frigidimarina NCIMB 400], gi\|69166032\|gb\|EA...	180.0	[0..1]	[228..3]
gi\|46156273, gi\|... - gi\|46156273\|ref\|ZP_00133144.2\| COG3340: Peptidase E [Haemophilus somnus 2336], gi\|170719006\|ref\|YP_0... gi\|53692699, gi\|... - gi\|53692699\|ref\|ZP_00347395.1\| COG3340: Peptidase E [Haemophilus somnus 129PT], gi\|113461388\|ref\|YP_...	179.0	[0..2]	[229..3]
gi\|46143863 - gi\|46143863\|ref\|ZP_00133840.2\| COG3340: Peptidase E [Actinobacillus pleuropneumoniae serovar 1 str. ... PEPE_ACTP2 - Peptidase E OS=Actinobacillus pleuropneumoniae serotype 5b (strain L20) GN=pepE PE=3 SV=1	179.0	[0..2]	[229..3]
gi\|12720709, gi\|... - gi\|15602319\|ref\|NP_245391.1\| peptidase E [Pasteurella multocida subsp. multocida str. Pm70], gi\|1272...	178.0	[0..2]	[229..12]
PEPE_SHEAM - Peptidase E OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=pepE PE=3 SV=1	178.0	[0..1]	[228..3]

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Predicted Domain #1

Region A:
Residues: [1-229]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELLLLSNST LPGKAWLEHA LPLIAEQLQG RRSAVFIPFA GVTQTWDDYT AKTAAVLAPL  60
   61 GVSVTGIHSV VDPVAAIENA EIVIVGGGNT FQLLKQCRER GLLAPITDVV KRGALYIGWS 120
  121 AGANLACPTI RTTNDMPIVD PQGFDALNLF PLQINPHFTN ALPEGHKGET REQRIRELLV 180
  181 VAPELTIIGL PEGNWITVSK GHATLGGPNT TYVFKAGEEA VPLEAGHRF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.0
Match:	1fy2A
Description:	Aspartyl dipeptidase PepE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.30391542469987	bayes_pls_golite062009
ligase activity	1.03859358394018	bayes_pls_golite062009
peptidase activity	0.931946117157141	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.422021910110542	bayes_pls_golite062009
hydrolase activity	0.121916378202276	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: