YRC Public Data Repository - Protein Structure Prediction

Protein:	PEN2_DANRE
Organism:	Danio rerio
Length:	101 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEN2_DANRE.

Description	E-value	Query Range	Subject Range
gi\|182890176, gi... - gi\|62204246\|gb\|AAH92674.1\| Presenilin enhancer 2 homolog [Danio rerio], gi\|182890176\|gb\|AAI64817.1\| ...	157.0	[0..1]	[101..1]
gi\|47225578 - gi\|47225578\|emb\|CAG12061.1\| unnamed protein product [Tetraodon nigroviridis]	153.0	[0..1]	[99..1]
gi\|111305751, gi... - gi\|89266904\|emb\|CAJ82298.1\| presenilin enhancer 2 homolog (C. elegans) [Xenopus tropicalis], gi\|6285...	149.0	[0..1]	[99..1]
gi\|157111831, gi... - gi\|157111831\|ref\|XP_001651746.1\| presenilin enhancer, putative [Aedes aegypti], gi\|108878286\|gb\|EAT4...	147.0	[0..1]	[101..1]
gi\|52138949, gi\|... - gi\|76779902\|gb\|AAI06245.1\| LOC494701 protein [Xenopus laevis], gi\|52138949\|gb\|AAH82697.1\| LOC494701 ...	147.0	[0..1]	[99..1]
gi\|195584533, gi... - gi\|195584533\|ref\|XP_002082059.1\| GD11355 [Drosophila simulans], gi\|194194068\|gb\|EDX07644.1\| GD11355 ... gi\|195487535, gi... - gi\|195487535\|ref\|XP_002091948.1\| GE11942 [Drosophila yakuba], gi\|194178049\|gb\|EDW91660.1\| GE11942 [D... pen-2-PA, FBpp03... - The gene presenilin enhancer is referred to in FlyBase by the symbol Dmel\pen-2 (CG33198, FBgn005319...	145.0	[0..1]	[101..1]
gi\|91084865 - gi\|91084865\|ref\|XP_968065.1\| PREDICTED: similar to CG33198-PA [Tribolium castaneum]	145.0	[0..1]	[100..1]
gi\|114052008, gi... - gi\|87248387\|gb\|ABD36246.1\| presenilin enhancer [Bombyx mori], gi\|114052008\|ref\|NP_001040205.1\| prese...	145.0	[0..1]	[101..1]

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Predicted Domain #1

Region A:
Residues: [1-101]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLERIPNEE KLSLCRRYYL GGFAFLPFLW LVNILWFFKE AFLKPAYTEQ PQIKSYVKKS  60
   61 ALGLLLWVAV LTTWITVFQH FRAQWGEVGD YLSFTIPLGT A

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.915	0.042	membrane attack complex	a.7.1	Spectrin repeat
View	Download	0.979	0.042	membrane attack complex	a.24.9	alpha-catenin/vinculin
View	Download	0.956	0.042	membrane attack complex	a.2.7	tRNA-binding arm
View	Download	0.972	0.042	membrane attack complex	a.7.5	Tubulin chaperone cofactor A
View	Download	0.917	0.042	membrane attack complex	a.2.8	Eukaryotic DNA topoisomerase I, dispensable insert domain

Predicted functions:

Term	Confidence	Notes
binding	2.44862313972188	bayes_pls_golite062009
protein binding	1.69141488569616	bayes_pls_golite062009
cadherin binding	0.655643448891613	bayes_pls_golite062009
cell adhesion molecule binding	0.474766150716424	bayes_pls_golite062009
catalytic activity	0.20779478258019	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: