YRC Public Data Repository - Protein Structure Prediction

Protein:	NUDH_ECOLI
Organism:	Escherichia coli
Length:	176 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUDH_ECOLI.

Description	E-value	Query Range	Subject Range
RPPH_SHISS - RNA pyrophosphohydrolase OS=Shigella sonnei (strain Ss046) GN=rppH PE=3 SV=1 RPPH_SHIB3 - RNA pyrophosphohydrolase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=rppH PE=3 SV...	176.0	[0..1]	[176..1]
RPPH_HAEI8 - RNA pyrophosphohydrolase OS=Haemophilus influenzae (strain 86-028NP) GN=rppH PE=3 SV=1	175.0	[0..1]	[173..1]
RPPH_SHIBS - RNA pyrophosphohydrolase OS=Shigella boydii serotype 4 (strain Sb227) GN=rppH PE=3 SV=1	172.0	[0..1]	[176..1]
RPPH_PHOLL - RNA pyrophosphohydrolase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565... RPPH_PHOLL, NUDH... - RNA pyrophosphohydrolase OS=Photorhabdus luminescens subsp. laumondii GN=rppH PE=3 SV=1, Probable - ...	172.0	[0..1]	[175..1]
RPPH_SALTY - RNA pyrophosphohydrolase OS=Salmonella typhimurium GN=rppH PE=3 SV=1 RPPH_SALCH - RNA pyrophosphohydrolase OS=Salmonella choleraesuis GN=rppH PE=3 SV=1 RPPH_SALPA, NUDH... - RNA pyrophosphohydrolase OS=Salmonella paratyphi A GN=rppH PE=3 SV=1, Probable - Salmonella paratyph... NUDH_SALCH, RPPH... - RNA pyrophosphohydrolase OS=Salmonella choleraesuis GN=rppH PE=3 SV=1, Probable - Salmonella cholera... RPPH_SALSV - RNA pyrophosphohydrolase OS=Salmonella schwarzengrund (strain CVM19633) GN=rppH PE=3 SV=1 RPPH_SALA4 - RNA pyrophosphohydrolase OS=Salmonella agona (strain SL483) GN=rppH PE=3 SV=1 gi\|197241962, gi... - gi\|197263707\|ref\|ZP_03163781.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. e... RPPH_SALPK - RNA pyrophosphohydrolase OS=Salmonella paratyphi A (strain AKU_12601) GN=rppH PE=3 SV=1 lcl\|NC_016856.1_... - [gene=ygdP] [protein=dinucleoside polyphosphate hydrolase] [protein_id=YP_005239126.1] [location=com... gi\|205342973, gi... - gi\|205342973\|gb\|EDZ29737.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... RPPH_SALNS - RNA pyrophosphohydrolase OS=Salmonella newport (strain SL254) GN=rppH PE=3 SV=1 RPPH_SALHS - RNA pyrophosphohydrolase OS=Salmonella heidelberg (strain SL476) GN=rppH PE=3 SV=1 gi\|194469533, gi... - gi\|194469533\|ref\|ZP_03075517.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. e... gi\|197290657, gi... - gi\|197290657\|gb\|EDY30011.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... RPPH_SALTI - RNA pyrophosphohydrolase OS=Salmonella typhi GN=rppH PE=3 SV=1 gi\|205338219, gi... - gi\|205338219\|gb\|EDZ24983.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... RPPH_SALPB - RNA pyrophosphohydrolase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=rppH PE=3 SV=1 gi\|168261844, gi... - gi\|205349100\|gb\|EDZ35731.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... gi\|168463839, gi... - gi\|195633181\|gb\|EDX51595.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... gi\|16761781 - gi\|16761781\|ref\|NP_457398.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. enteri... gi\|167550122, gi... - gi\|205324879\|gb\|EDZ12718.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... gi\|238909782 - gi\|238909782\|ref\|ZP_04653619.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... RPPH_SALTY - RNA pyrophosphohydrolase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=rppH PE=... gi\|205328478, gi... - gi\|205328478\|gb\|EDZ15242.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... gi\|29143265, gi\|... - gi\|29143265\|ref\|NP_806607.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. enteri... gi\|205334441, gi... - gi\|205334441\|gb\|EDZ21205.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. enter... gi\|214000418 - gi\|214000418\|ref\|ZP_03411153.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... RPPH_SALPC - RNA pyrophosphohydrolase OS=Salmonella paratyphi C (strain RKS4594) GN=rppH PE=3 SV=1 gi\|213586823 - gi\|213586823\|ref\|ZP_03368649.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... gi\|213620570 - gi\|213620570\|ref\|ZP_03373353.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... gi\|213650271 - gi\|213650271\|ref\|ZP_03380324.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... gi\|213850173 - gi\|213850173\|ref\|ZP_03381071.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... RPPH_SALEP - RNA pyrophosphohydrolase OS=Salmonella enteritidis PT4 (strain P125109) GN=rppH PE=3 SV=1 gi\|213023730 - gi\|213023730\|ref\|ZP_03338177.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... gi\|213051493 - gi\|213051493\|ref\|ZP_03344371.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... gi\|213428465 - gi\|213428465\|ref\|ZP_03361215.1\| dinucleoside polyphosphate hydrolase [Salmonella enterica subsp. ent... RPPH_SALDC - RNA pyrophosphohydrolase OS=Salmonella dublin (strain CT_02021853) GN=rppH PE=3 SV=1 gi\|199604909, gi... - gi\|200387811\|ref\|ZP_03214423.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. e... gi\|204928379, gi... - gi\|204928379\|ref\|ZP_03219579.1\| (Di)nucleoside polyphosphate hydrolase [Salmonella enterica subsp. e... RPPH_SALG2 - RNA pyrophosphohydrolase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=rppH PE=3 SV=1 RPPH_SALCH - RNA pyrophosphohydrolase OS=Salmonella choleraesuis (strain SC-B67) GN=rppH PE=3 SV=1 NUDH_SALTI, RPPH... - RNA pyrophosphohydrolase OS=Salmonella typhi GN=rppH PE=3 SV=1, Probable - Salmonella typhi RPPH_SALPA - RNA pyrophosphohydrolase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=rppH PE=3 SV=1 NUDH_SALTY, RPPH... - RNA pyrophosphohydrolase OS=Salmonella typhimurium GN=rppH PE=3 SV=1, Probable - Salmonella typhimur... RPPH_SALPB - RNA pyrophosphohydrolase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=rppH PE=3 SV=1	172.0	[0..1]	[176..1]
NUDH_PASMU, RPPH... - RNA pyrophosphohydrolase OS=Pasteurella multocida GN=rppH PE=3 SV=1, Probable - Pasteurella multocid... RPPH_PASMU - RNA pyrophosphohydrolase OS=Pasteurella multocida (strain Pm70) GN=rppH PE=3 SV=1	172.0	[0..1]	[171..1]
gi\|229813037, gi... - gi\|229844043\|ref\|ZP_04464184.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae 6P18H1]... gi\|42631225 - gi\|42631225\|ref\|ZP_00156763.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ... gi\|145641911, gi... - gi\|145641911\|ref\|ZP_01797485.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae R3021],... gi\|145641911 - gi\|145641911\|ref\|ZP_01797485.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae R3021] gi\|145636968, gi... - gi\|145636968\|ref\|ZP_01792632.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae PittHH]... gi\|145634069, gi... - gi\|145634069\|ref\|ZP_01789780.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae PittAA]... gi\|145632279, gi... - gi\|145632279\|ref\|ZP_01788014.1\| dinucleoside polyphosphate hydrolase [Haemophilus influenzae 3655], ...	171.0	[0..1]	[172..1]
gi\|238787268, gi... - gi\|77974547\|ref\|ZP_00830087.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	171.0	[0..1]	[176..1]
gi\|238719553, gi... - gi\|77963208\|ref\|ZP_00827020.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	171.0	[0..1]	[176..1]
gi\|77958901, gi\|... - gi\|77958901\|ref\|ZP_00822927.1\| COG0494: NTP pyrophosphohydrolases including oxidative damage repair ...	171.0	[0..1]	[176..1]

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Predicted Domain #1

Region A:
Residues: [1-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDDDGYRPN VGIVICNRQG QVMWARRFGQ HSWQFPQGGI NPGESAEQAM YRELFEEVGL  60
   61 SRKDVRILAS TRNWLRYKLP KRLVRWDTKP VCIGQKQKWF LLQLVSGDAE INMQTSSTPE 120
  121 FDGWRWVSYW YPVRQVVSFK RDVYRRVMKE FASVVMSLQE NTPKPQNASA YRRKRG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.39794
Match:	1f3yA
Description:	Diadenosine tetraphosphate hydrolase (Ap4A hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	1.86826130963189	bayes_pls_golite062009
catalytic activity	1.86119802438676	bayes_pls_golite062009
RNA pyrophosphohydrolase activity	0.681788425915311	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.544115189438	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.54377405132398	bayes_pls_golite062009
nucleic acid binding	0.468153646537656	bayes_pls_golite062009
binding	0.0581982566440131	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: