YRC Public Data Repository - Protein Structure Prediction

Protein:	NPC2_BOVIN
Organism:	Bos taurus
Length:	149 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPC2_BOVIN.

Description	E-value	Query Range	Subject Range
gi\|74212648 - gi\|74212648\|dbj\|BAE31061.1\| unnamed protein product [Mus musculus]	171.0	[0..1]	[149..1]
gi\|27465565, gi\|... - gi\|34786047\|gb\|AAH58132.1\| Niemann-Pick disease, type C2 [Rattus norvegicus], gi\|27465565\|ref\|NP_775...	166.0	[0..1]	[149..1]
gi\|62896507 - gi\|62896507\|dbj\|BAD96194.1\| Niemann-Pick disease, type C2 precursor variant [Homo sapiens]	165.0	[0..16]	[149..16]
gi\|148234356, gi... - gi\|46249888\|gb\|AAH68868.1\| MGC82279 protein [Xenopus laevis], gi\|148234356\|ref\|NP_001084605.1\| hypot...	159.0	[0..4]	[148..5]
gi\|151567604, gi... - gi\|28373999\|pdb\|1NEP\|A Chain A, Crystal Structure Analysis Of The Bovine Npc2 (Niemann-Pick C2) Prot...	159.0	[0..20]	[149..1]
NPC2_DANRE - Epididymal secretory protein E1 OS=Danio rerio GN=npc2 PE=2 SV=1	157.0	[0..1]	[148..1]

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Predicted Domain #1

Region A:
Residues: [1-149]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLTVAFLF LALSASALAE PVKFKDCGSW VGVIKEVNVS PCPTQPCKLH RGQSYSVNVT  60
   61 FTSNTQSQSS KAVVHGIVMG IPVPFPIPES DGCKSGIRCP IEKDKTYNYV NKLPVKNEYP 120
  121 SIKVVVEWEL TDDKNQRFFC WQIPIEVEA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.39794
Match:	1nepA
Description:	Epididymal secretory protein E1 (Niemann-Pick C2 protein)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits