YRC Public Data Repository - Protein Structure Prediction

Protein:	MVIM_ECOLI
Organism:	Escherichia coli
Length:	307 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MVIM_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|146296197, gi... - gi\|82499511\|ref\|ZP_00884954.1\| NADH-dependent dyhydrogenase [Caldicellulosiruptor saccharolyticus DS...	254.0	[0..1]	[306..1]
gi\|20807145 - gi\|20807145\|ref\|NP_622316.1\| predicted dehydrogenase and related proteins [Thermoanaerobacter tengco... gi\|20807145, gi\|... - gi\|20807145\|ref\|NP_622316.1\| dehydrogenase and related proteins [Thermoanaerobacter tengcongensis MB...	240.0	[0..2]	[306..3]
gi\|89097633, gi\|... - gi\|89097633\|ref\|ZP_01170521.1\| NADH-dependent dyhydrogenase [Bacillus sp. NRRL B-14911], gi\|89087492...	239.0	[0..1]	[306..1]
gi\|110605340, gi... - gi\|119719921\|ref\|YP_920416.1\| oxidoreductase domain-containing protein [Thermofilum pendens Hrk 5], ...	238.0	[0..1]	[306..1]
gi\|15643180, gi\|... - gi\|4980919\|gb\|AAD35499.1\|AE001720_13 dehydrogenase [Thermotoga maritima MSB8], gi\|15643180\|ref\|NP_22... gi\|7445304 - pir\|\|D72381 dehydrogenase - Thermotoga maritima (strain MSB8)	237.0	[0..4]	[307..1]
gi\|15613811, gi\|... - gi\|15613811\|ref\|NP_242114.1\| NADH-dependent dyhydrogenase [Bacillus halodurans C-125], gi\|10173864\|d... gi\|25493503 - pir\|\|H83805 NADH-dependent dyhydrogenase BH1248 [imported] - Bacillus halodurans (strain C-125)	236.0	[0..1]	[306..1]
gi\|56908808, gi\|... - gi\|56962570\|ref\|YP_174296.1\| NADH-dependent dyhydrogenase [Bacillus clausii KSM-K16], gi\|56908808\|db...	233.0	[0..1]	[307..1]
gi\|14024919, gi\|... - gi\|14024919\|dbj\|BAB51521.1\| myo-inositol dehydrogenase; IdhA [Mesorhizobium loti MAFF303099], gi\|134...	231.0	[0..3]	[306..2]

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Predicted Domain #1

Region A:
Residues: [1-307]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKLRIGVVG LGGIAQKAWL PVLAAASDWT LQGAWSPTRA KALPICESWR IPYADSLSSL  60
   61 AASCDAVFVH SSTASHFDVV STLLNAGVHV CVDKPLAENL RDAERLVELA ARKKLTLMVG 120
  121 FNRRFAPLYG ELKTQLATAA SLRMDKHRSN SVGPHDLYFT LLDDYLHVVD TALWLSGGKA 180
  181 SLDGGTLLTN DAGEMLFAEH HFSAGPLQIT TCMHRRAGSQ RETVQAVTDG ALIDITDMRE 240
  241 WREERGQGVV HKPIPGWQST LEQRGFVGCA RHFIECVQNQ TVPQTAGEQA VLAQRIVDKI 300
  301 WRDAMSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.39794
Match:	1tltA
Description:	Crystal Structure of a Putative Oxidoreductase (VIRULENCE FACTOR mviM HOMOLOG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.91887313269429	bayes_pls_golite062009
oxidoreductase activity	2.04591629313591	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.133527946988034	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.132424363428837	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: