YRC Public Data Repository - Protein Structure Prediction

Protein:	MLRA_ECOLI
Organism:	Escherichia coli
Length:	243 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MLRA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|190909645, gi... - gi\|75242944\|ref\|ZP_00726650.1\| COG0789: Predicted transcriptional regulators [Escherichia coli F11],... gi\|110343927, gi... - gi\|110642335\|ref\|YP_670065.1\| MerR-like regulator A [Escherichia coli 536], gi\|110343927\|gb\|ABG70164...	202.0	[0..1]	[243..1]
gi\|82777390, gi\|... - gi\|82777390\|ref\|YP_403739.1\| putative transcriptional regulator [Shigella dysenteriae Sd197], gi\|812...	202.0	[0..1]	[243..1]
gi\|253974042, gi... - gi\|254162141\|ref\|YP_003045249.1\| DNA-binding transcriptional regulator [Escherichia coli B str. REL6... gi\|253323990, gi... - gi\|254288903\|ref\|YP_003054651.1\| DNA-binding transcriptional regulator [Escherichia coli BL21(DE3)],... gi\|194436166, gi... - gi\|83588109\|ref\|ZP_00926734.1\| COG0789: Predicted transcriptional regulators [Escherichia coli 101-1... gi\|242377768, gi... - gi\|251785495\|ref\|YP_002999799.1\| hypothetical protein B21_02014 [Escherichia coli BL21], gi\|24237776...	201.0	[0..1]	[243..1]
gi\|117624330, gi... - gi\|117624330\|ref\|YP_853243.1\| MerR-like regulator A [Escherichia coli APEC O1], gi\|115513454\|gb\|ABJ0... gi\|237704587, gi... - gi\|237704587\|ref\|ZP_04535068.1\| conserved hypothetical protein [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|91072986, gi\|... - gi\|91211412\|ref\|YP_541398.1\| putative transcriptional regulator [Escherichia coli UTI89], gi\|9107298... gi\|218559045, gi... - gi\|218559045\|ref\|YP_002391958.1\| DNA-binding transcriptional regulator [Escherichia coli S88], gi\|21...	200.0	[0..1]	[243..1]
gi\|26108910, gi\|... - gi\|26248505\|ref\|NP_754545.1\| MerR-like regulator A [Escherichia coli CFT073], gi\|26108910\|gb\|AAN8111... gi\|227887181, gi... - gi\|227887181\|ref\|ZP_04004986.1\| MerR family regulator A [Escherichia coli 83972], gi\|227835531\|gb\|EE...	200.0	[0..1]	[243..1]
gi\|213999815 - gi\|213999815\|ref\|ZP_03410550.1\| putative transcriptional regulator [Salmonella enterica subsp. enter... gi\|29136827, gi\|... - gi\|29141201\|ref\|NP_804543.1\| putative transcriptional regulator [Salmonella enterica subsp. enterica... gi\|213428238 - gi\|213428238\|ref\|ZP_03360988.1\| putative transcriptional regulator [Salmonella enterica subsp. enter... gi\|16761103 - gi\|16761103\|ref\|NP_456720.1\| putative transcriptional regulator [Salmonella enterica subsp. enterica... gi\|213650024 - gi\|213650024\|ref\|ZP_03380077.1\| putative transcriptional regulator [Salmonella enterica subsp. enter... gi\|213852443 - gi\|213852443\|ref\|ZP_03381975.1\| putative transcriptional regulator [Salmonella enterica subsp. enter... gi\|25325263, gi\|... - gi\|25325263\|pir\|\|AF0777 probable transcription regulator STY2390 [imported] - Salmonella enterica su... gi\|213976268 - gi\|213976268\|ref\|ZP_03403527.1\| putative transcriptional regulator [Salmonella enterica subsp. enter... gi\|213027116 - gi\|213027116\|ref\|ZP_03341563.1\| putative transcriptional regulator [Salmonella enterica subsp. enter... gi\|213053218 - gi\|213053218\|ref\|ZP_03346096.1\| putative transcriptional regulator [Salmonella enterica subsp. enter...	180.0	[0..1]	[243..1]
gi\|194456184, gi... - gi\|194469820\|ref\|ZP_03075804.1\| transcriptional regulator, MerR family protein [Salmonella enterica ... gi\|168818134, gi... - gi\|205344751\|gb\|EDZ31515.1\| transcriptional regulator, MerR family protein [Salmonella enterica subs... gi\|195631163, gi... - gi\|195631163\|gb\|EDX49723.1\| transcriptional regulator, MerR family protein [Salmonella enterica subs... gi\|205350932, gi... - gi\|205350932\|gb\|EDZ37563.1\| transcriptional regulator, MerR family protein [Salmonella enterica subs... gi\|197361857, gi... - gi\|197361857\|ref\|YP_002141493.1\| putative transcriptional regulator [Salmonella enterica subsp. ente... gi\|197264719, gi... - gi\|197264719\|ref\|ZP_03164793.1\| transcriptional regulator, MerR family protein [Salmonella enterica ... gi\|197251805, gi... - gi\|197251805\|ref\|YP_002147132.1\| transcriptional regulator, MerR family protein [Salmonella enterica... gi\|194738337, gi... - gi\|194738337\|ref\|YP_002115250.1\| transcriptional regulator, MerR family protein [Salmonella enterica... gi\|161362516, gi... - gi\|161613152\|ref\|YP_001587117.1\| hypothetical protein SPAB_00860 [Salmonella enterica subsp. enteric... MLRA_SALTY - HTH-type transcriptional regulator mlrA OS=Salmonella typhimurium GN=mlrA PE=3 SV=1 gi\|56412926, gi\|... - gi\|56412926\|ref\|YP_150001.1\| putative transcriptional regulator [Salmonella enterica subsp. enterica... gi\|168236326, gi... - gi\|197290545\|gb\|EDY29900.1\| transcriptional regulator, MerR family protein [Salmonella enterica subs... gi\|205335583, gi... - gi\|205335583\|gb\|EDZ22347.1\| transcriptional regulator, MerR family protein [Salmonella enterica subs... gi\|205330457, gi... - gi\|205330457\|gb\|EDZ17221.1\| transcriptional regulator, MerR family protein [Salmonella enterica subs... gi\|167551113, gi... - gi\|205324022\|gb\|EDZ11861.1\| transcriptional regulator, MerR family protein [Salmonella enterica subs... MLRA_SALTY - HTH-type transcriptional regulator mlrA OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7007... lcl\|NC_016856.1_... - [gene=yehV] [protein=putative transcriptional repressor] [protein_id=YP_005238203.1] [location=23079... gi\|238912603 - gi\|238912603\|ref\|ZP_04656440.1\| putative transcriptional regulator [Salmonella enterica subsp. enter... MLRA_SALTS - HTH-type transcriptional regulator mlrA OS=Salmonella typhimurium (strain SL1344) GN=mlrA PE=3 SV=1 gi\|224583338, gi... - gi\|224583338\|ref\|YP_002637136.1\| putative transcriptional regulator [Salmonella enterica subsp. ente... gi\|204321845, gi... - gi\|204929301\|ref\|ZP_03220444.1\| transcriptional regulator, MerR family protein [Salmonella enterica ... MLRA_SALTY - HTH-type transcriptional regulator mlrA OS=Salmonella typhimurium GN=mlrA PE=4 SV=1 gi\|199605929, gi... - gi\|200388831\|ref\|ZP_03215443.1\| transcriptional regulator, MerR family protein [Salmonella enterica ...	179.0	[0..1]	[243..1]
gi\|62128379, gi\|... - gi\|62180746\|ref\|YP_217163.1\| MerR family transcriptional regulator [Salmonella enterica subsp. enter...	177.0	[0..1]	[243..1]

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Predicted Domain #1

Region A:
Residues: [1-130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALYTIGEVA LLCDINPVTL RAWQRRYGLL KPQRTDGGHR LFNDADIDRI REIKRWIDNG  60
   61 VQVSKVKMLL SNENVDVQNG WRDQQETLLT YLQSGNLHSL RTWIKERGQD YPAQTLTTHL 120
  121 FIPLRRRLQC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.69897
Match:	1q05A
Description:	Crystal structure of the Cu(I) form of E. coli CueR, a copper efflux regulator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.40729334364274	bayes_pls_golite062009
DNA binding	2.05877861880033	bayes_pls_golite062009
nucleic acid binding	1.99474406643819	bayes_pls_golite062009
transcription factor activity	1.84836087644732	bayes_pls_golite062009
binding	1.32395331736751	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [131-243]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQPTLQALLA ILDGVLINYI AICLASARKK QGKDALVVGW NIQDTTRLWL EGWIASQQGW  60
   61 RIDVLAHSLN QLRPELFEGR TLLVWCGENR TSAQQQQLTS WQEQGHDIFP LGI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.635	0.896	nucleotide binding	c.37.1	P-loop containing nucleoside triphosphate hydrolases

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: