YRC Public Data Repository - Protein Structure Prediction

Protein:	MHPF_ECOLI
Organism:	Escherichia coli
Length:	316 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MHPF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|19033981, gi\|... - gi\|19033981\|gb\|AAL83664.1\| acetaldehyde dehydrogenase [Pseudomonas putida], gi\|111116467\|ref\|YP_7093...	417.0	[0..2]	[311..3]
ACDH2_AZOVD - Acetaldehyde dehydrogenase 2 OS=Azotobacter vinelandii (strain DJ / ATCC BAA-1303) GN=mhpF PE=3 SV=1 gi\|67154475 - gi\|67154475\|ref\|ZP_00416220.1\| Acetaldehyde dehydrogenase [Azotobacter vinelandii AvOP]	414.0	[0..1]	[311..1]
gi\|9957554, gi\|7... - gi\|9957554\|gb\|AAG09415.1\|AF180147_7 acylating aldehyde dehydrogenase TobI [Pseudomonas putida], gi\|7... ACDH1_PSEP1 - Acetaldehyde dehydrogenase 1 OS=Pseudomonas putida (strain F1 / ATCC 700007) GN=Pput_2874 PE=3 SV=1 tr\|I7C122\|I7C122... - Acetaldehyde dehydrogenase OS=Pseudomonas putida (strain DOT-T1E) GN=tobI PE=3 SV=1	413.0	[0..2]	[314..3]
ACDH3_DECAR - Acetaldehyde dehydrogenase 3 OS=Dechloromonas aromatica (strain RCB) GN=Daro_3239 PE=3 SV=1	411.0	[0..2]	[312..3]
gi\|27817711 - gi\|27817711\|emb\|CAD61138.1\| acetaldehyde dehydrogenase oxidoreductase [Cupriavidus oxalaticus] ACDH_BURCE - Acetaldehyde dehydrogenase OS=Burkholderia cepacia GN=bphG PE=3 SV=1	410.0	[0..2]	[311..3]
gi\|189356906, gi... - gi\|189356906\|gb\|EDU75325.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4401], gi\|16... gi\|168749802, gi... - gi\|188015913\|gb\|EDU54035.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4113], gi\|16... gi\|13359863, gi\|... - gi\|15829660\|ref\|NP_308433.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. Sakai], gi\|13... gi\|168784253, gi... - gi\|188998555\|gb\|EDU67543.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4076], gi\|16... gi\|168777900, gi... - gi\|187766961\|gb\|EDU30805.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4196], gi\|16... ACDH_ECO57 - Acetaldehyde dehydrogenase OS=Escherichia coli O157:H7 GN=mhpF PE=3 SV=1 gi\|168768290, gi... - gi\|189362428\|gb\|EDU80847.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4486], gi\|16... gi\|209744590, gi... - pir\|\|B85530 acetaldehyde dehydrogenase [imported] - Escherichia coli (strain O157:H7, substrain EDL... gi\|168761486, gi... - gi\|189367990\|gb\|EDU86406.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4501], gi\|16... gi\|12513187, gi\|... - gi\|15800082\|ref\|NP_286094.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 EDL933], gi\|125131... gi\|254791532, gi... - gi\|254791532\|ref\|YP_003076369.1\| acetaldehyde-CoA dehydrogenase II, NAD-binding [Escherichia coli O1... gi\|208729231, gi... - gi\|208809430\|ref\|ZP_03251767.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4206], g... gi\|195940227 - gi\|195940227\|ref\|ZP_03085609.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4024] gi\|168802593, gi... - gi\|189375450\|gb\|EDU93866.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC508], gi\|168... gi\|189370060, gi... - gi\|189370060\|gb\|EDU88476.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC869], gi\|168... gi\|217321219, gi... - gi\|217324998\|ref\|ZP_03441082.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. TW14588], ... ACDH_ECO5E - Acetaldehyde dehydrogenase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mhpF PE=3 SV=1 gi\|208822815, gi... - gi\|208822815\|ref\|ZP_03263133.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4042], g... gi\|208815365, gi... - gi\|208815365\|ref\|ZP_03256544.1\| acetaldehyde dehydrogenase [Escherichia coli O157:H7 str. EC4045], g...	408.0	[0..1]	[316..1]
ACDH_CUPPJ - Acetaldehyde dehydrogenase OS=Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) GN=Reut_B5824 P...	407.0	[0..2]	[311..4]

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Predicted Domain #1

Region A:
Residues: [1-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRM GVATTHEGVI  60
   61 GLMNMPEFAD IDIVFDATSA GAHVKNDAAL REAKPDIRLI DLTPAAIGPY CVPVVNLEAN 120
  121 VDQLNVNMVT CGGQATIPMV AAVSRVARVH YAEIIASIAS KSAGPGTRAN IDEFTETTSR 180
  181 AIEVVGGAAK GKAIIVLNPA EPPLMMRDTV YVLSDEASQD DIEASINEMA EAVQAYVPGY 240
  241 RLKQRVQFEV IPQDKPVNLP GVGQFSGLKT AVWLEVEGAA HYLPAYAGNL DIMTSSALAT 300
  301 AEKMAQSLAR KAGEAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	1nvmB
Description:	Acetaldehyde dehydrogenase (acylating)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.91887313269429	bayes_pls_golite062009
oxidoreductase activity	2.81525079586603	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity	0.98853891301554	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.241113029381333	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.240794684270136	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.12584210033497	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.0984551953336004	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	6.16654260099381E-5	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: