YRC Public Data Repository - Protein Structure Prediction

Protein:	MGSA_ECOLI
Organism:	Escherichia coli
Length:	152 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MGSA_ECOLI.

Description	E-value	Query Range	Subject Range
MGSA_VIBVU - Methylglyoxal synthase OS=Vibrio vulnificus GN=mgsA PE=3 SV=1 MGSA_VIBVY - Methylglyoxal synthase OS=Vibrio vulnificus (strain YJ016) GN=mgsA PE=3 SV=1 MGSA_VIBVU - Methylglyoxal synthase OS=Vibrio vulnificus (strain CMCP6) GN=mgsA PE=3 SV=1	174.0	[0..1]	[151..1]
MGSA_ECO81 - Methylglyoxal synthase OS=Escherichia coli O81 (strain ED1a) GN=mgsA PE=3 SV=1 sp\|B7UN42\|MGSA_ECO27 - Methylglyoxal synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=mgsA PE=3 SV=1 gi\|190907301, gi... - gi\|191172417\|ref\|ZP_03033958.1\| methylglyoxal synthase [Escherichia coli F11], gi\|190907301\|gb\|EDV66... MGSA_ECOL6 - Methylglyoxal synthase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=mgsA PE=3 S... MGSA_ECO45 - Methylglyoxal synthase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mgsA PE=3 SV=1 MGSA_ECOL6 - Methylglyoxal synthase OS=Escherichia coli O6 GN=mgsA PE=3 SV=2 MGSA_ECO27 - Methylglyoxal synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=mgsA PE=3 SV=1	172.0	[0..1]	[152..1]
gi\|227884077, gi... - gi\|227884077\|ref\|ZP_04001882.1\| methylglyoxal synthase [Escherichia coli 83972], gi\|227838829\|gb\|EEJ... gi\|75240582 - gi\|75240582\|ref\|ZP_00724499.1\| COG1803: Methylglyoxal synthase [Escherichia coli F11] gi\|237707052, gi... - gi\|237707052\|ref\|ZP_04537533.1\| methylglyoxal synthase [Escherichia sp. 3_2_53FAA], gi\|226898262\|gb\|... gi\|91071633, gi\|... - gi\|91210059\|ref\|YP_540045.1\| methylglyoxal synthase [Escherichia coli UTI89], gi\|91071633\|gb\|ABE0651... gi\|110641153, gi... - gi\|110641153\|ref\|YP_668883.1\| methylglyoxal synthase [Escherichia coli 536], gi\|110342745\|gb\|ABG6898... gi\|26107385, gi\|... - gi\|26246985\|ref\|NP_753025.1\| methylglyoxal synthase [Escherichia coli CFT073], gi\|26107385\|gb\|AAN795... gi\|117623173, gi... - gi\|117623173\|ref\|YP_852086.1\| methylglyoxal synthase [Escherichia coli APEC O1], gi\|115512297\|gb\|ABJ...	172.0	[0..1]	[152..4]
MGSA_VIBPA - Methylglyoxal synthase OS=Vibrio parahaemolyticus GN=mgsA PE=3 SV=1 MGSA_VIBPA - Methylglyoxal synthase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=mgsA PE=3 ... gi\|153838728, gi... - gi\|153838728\|ref\|ZP_01991395.1\| methylglyoxal synthase [Vibrio parahaemolyticus AQ3810], gi\|14974785...	172.0	[0..1]	[150..1]
gi\|82776254, gi\|... - gi\|82776254\|ref\|YP_402603.1\| methylglyoxal synthase [Shigella dysenteriae Sd197], gi\|81240402\|gb\|ABB... gi\|82544713, gi\|... - gi\|82544713\|ref\|YP_408660.1\| methylglyoxal synthase [Shigella boydii Sb227], gi\|81246124\|gb\|ABB66832... gi\|75190031 - gi\|75190031\|ref\|ZP_00703298.1\| COG1803: Methylglyoxal synthase [Escherichia coli E24377A] gi\|75195152 - gi\|75195152\|ref\|ZP_00705222.1\| COG1803: Methylglyoxal synthase [Escherichia coli HS] gi\|83584615 - gi\|83584615\|ref\|ZP_00923284.1\| COG1803: Methylglyoxal synthase [Escherichia coli 101-1] gi\|15830301, gi\|... - gi\|15830301\|ref\|NP_309074.1\| methylglyoxal synthase [Escherichia coli O157:H7 str. Sakai], gi\|133605... gi\|75175476 - gi\|75175476\|ref\|ZP_00695696.1\| COG1803: Methylglyoxal synthase [Shigella boydii BS512] gi\|75255125 - gi\|75255125\|ref\|ZP_00727012.1\| COG1803: Methylglyoxal synthase [Escherichia coli E22] gi\|74311520, gi\|... - gi\|74311520\|ref\|YP_309939.1\| methylglyoxal synthase [Shigella sonnei Ss046], gi\|73854997\|gb\|AAZ87704... gi\|75230238 - gi\|75230238\|ref\|ZP_00716735.1\| COG1803: Methylglyoxal synthase [Escherichia coli B7A] gi\|75235199 - gi\|75235199\|ref\|ZP_00719441.1\| COG1803: Methylglyoxal synthase [Escherichia coli E110019] gi\|124529145, gi... - gi\|124529145\|ref\|ZP_01700255.1\| methylglyoxal synthase [Escherichia coli B], gi\|124500100\|gb\|EAY4757... gi\|24051245, gi\|... - gi\|24112376\|ref\|NP_706886.1\| methylglyoxal synthase [Shigella flexneri 2a str. 301], gi\|24051245\|gb\|... gi\|209774384, gi... - gi\|7451073\|pir\|\|B64837 methylglyoxal synthase (EC 4.2.3.3) [similarity] - Escherichia coli (strain K... gi\|15830301, gi\|... - gi\|15830301\|ref\|NP_309074.1\| methylglyoxal synthase [Escherichia coli O157:H7], gi\|13360507\|dbj\|BAB3... gi\|30040748, gi\|... - gi\|30062502\|ref\|NP_836673.1\| methylglyoxal synthase [Shigella flexneri 2a str. 2457T], gi\|30040748\|g... gi\|15800822, gi\|... - gi\|15800822\|ref\|NP_286838.1\| methylglyoxal synthase [Escherichia coli O157:H7 EDL933], gi\|12514148\|g... gi\|16128930, gi\|... - dbj\|BAA35728.1\| Hypothetical protein in held 3'region . [Escherichia coli K12], gb\|AAC74049.1\| meth...	171.0	[0..1]	[152..4]
MGSA_ERWCT - Methylglyoxal synthase OS=Erwinia carotovora subsp. atroseptica GN=mgsA PE=3 SV=1 MGSA_PECAS - Methylglyoxal synthase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=mgsA PE=3...	171.0	[0..1]	[152..1]
gi\|75513416 - gi\|75513416\|ref\|ZP_00735820.1\| COG1803: Methylglyoxal synthase [Escherichia coli 53638]	171.0	[0..1]	[152..4]
MGSA_HISS2 - Methylglyoxal synthase OS=Histophilus somni (strain 2336) GN=mgsA PE=3 SV=1	170.0	[0..1]	[152..1]
MGSA_HAES1 - Methylglyoxal synthase OS=Haemophilus somnus (strain 129Pt) GN=mgsA PE=3 SV=1	170.0	[0..1]	[152..1]
gi\|168237130, gi... - gi\|197289819\|gb\|EDY29180.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Schw... gi\|205332439, gi... - gi\|205332439\|gb\|EDZ19203.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Kent... gi\|205327305, gi... - gi\|205327305\|gb\|EDZ14069.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar 4,[5... gi\|205322790, gi... - gi\|205322790\|gb\|EDZ10629.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Sain... MGSA_SALTI - Methylglyoxal synthase OS=Salmonella typhi GN=mgsA PE=3 SV=1 gi\|168821817, gi... - gi\|205341665\|gb\|EDZ28429.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Welt... MGSA_SALTY - Methylglyoxal synthase OS=Salmonella typhimurium GN=mgsA PE=3 SV=1 gi\|168467517, gi... - gi\|195630089\|gb\|EDX48741.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Newp... gi\|168264163, gi... - gi\|205347376\|gb\|EDZ34007.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Hada... gi\|168243866, gi... - gi\|205337177\|gb\|EDZ23941.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Heid... MGSA_SALTI - Methylglyoxal synthase OS=Salmonella typhi GN=mgsA PE=3 SV=1 gi\|16759957 - gi\|16759957\|ref\|NP_455574.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Typ... MGSA_SALTY - Methylglyoxal synthase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=mgsA PE=3 ... gi\|29142271, gi\|... - gi\|29142271\|ref\|NP_805613.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar Typ... gi\|213028755 - gi\|213028755\|ref\|ZP_03343202.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... MGSA_SALEP - Methylglyoxal synthase OS=Salmonella enteritidis PT4 (strain P125109) GN=mgsA PE=3 SV=1 gi\|204930730, gi... - gi\|204930730\|ref\|ZP_03221603.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... gi\|200390828, gi... - gi\|200390828\|ref\|ZP_03217439.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... gi\|213580190 - gi\|213580190\|ref\|ZP_03362016.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... gi\|213425897 - gi\|213425897\|ref\|ZP_03358647.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... gi\|213417512 - gi\|213417512\|ref\|ZP_03350654.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... MGSA_SALCH - Methylglyoxal synthase OS=Salmonella choleraesuis GN=mgsA PE=3 SV=1 gi\|213160861 - gi\|213160861\|ref\|ZP_03346571.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... MGSA_SALSV - Methylglyoxal synthase OS=Salmonella schwarzengrund (strain CVM19633) GN=mgsA PE=3 SV=1 gi\|194469885, gi... - gi\|194469885\|ref\|ZP_03075869.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... MGSA_SALHS - Methylglyoxal synthase OS=Salmonella heidelberg (strain SL476) GN=mgsA PE=3 SV=1 MGSA_SALNS - Methylglyoxal synthase OS=Salmonella newport (strain SL254) GN=mgsA PE=3 SV=1 MGSA_SALPB - Methylglyoxal synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mgsA PE=3 SV=1 MGSA_SALDC - Methylglyoxal synthase OS=Salmonella dublin (strain CT_02021853) GN=mgsA PE=3 SV=1 MGSA_SALPA - Methylglyoxal synthase OS=Salmonella paratyphi A GN=mgsA PE=3 SV=1 MGSA_SALPK - Methylglyoxal synthase OS=Salmonella paratyphi A (strain AKU_12601) GN=mgsA PE=3 SV=1 MGSA_SALCH - Methylglyoxal synthase OS=Salmonella choleraesuis GN=mgsA PE=3 SV=1 gi\|197265815, gi... - gi\|197265815\|ref\|ZP_03165889.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... MGSA_SALAR - Methylglyoxal synthase OS=Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) GN=mgsA PE... MGSA_SALA4 - Methylglyoxal synthase OS=Salmonella agona (strain SL483) GN=mgsA PE=3 SV=1 gi\|238911101 - gi\|238911101\|ref\|ZP_04654938.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... MGSA_SALTY - Methylglyoxal synthase OS=Salmonella typhimurium GN=mgsA PE=3 SV=1 MGSA_SALCH - Methylglyoxal synthase OS=Salmonella choleraesuis (strain SC-B67) GN=mgsA PE=3 SV=1 MGSA_SALPA - Methylglyoxal synthase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=mgsA PE=3 SV=1 MGSA_SALPC - Methylglyoxal synthase OS=Salmonella paratyphi C (strain RKS4594) GN=mgsA PE=3 SV=1 gi\|214001663 - gi\|214001663\|ref\|ZP_03412398.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... gi\|213647172 - gi\|213647172\|ref\|ZP_03377225.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... gi\|213622021 - gi\|213622021\|ref\|ZP_03374804.1\| methylglyoxal synthase [Salmonella enterica subsp. enterica serovar ... lcl\|NC_016856.1_... - [gene=mgsA] [protein=methylglyoxal synthase] [protein_id=YP_005236810.1] [location=complement(112686... MGSA_SALPB - Methylglyoxal synthase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mgsA PE=3 SV=1	169.0	[0..1]	[152..1]

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Predicted Domain #1

Region A:
Residues: [1-152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELTTRTLPA RKHIALVAHD HCKQMLMSWV ERHQPLLEQH VLYATGTTGN LISRATGMNV  60
   61 NAMLSGPMGG DQQVGALISE GKIDVLIFFW DPLNAVPHDP DVKALLRLAT VWNIPVATNV 120
  121 ATADFIIQSP HFNDAVDILI PDYQRYLADR LK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.39794
Match:	1b93A
Description:	Methylglyoxal synthase, MgsA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methylglyoxal synthase activity	7.67158041469211	bayes_pls_golite062009
catalytic activity	2.05174935916901	bayes_pls_golite062009
carbon-oxygen lyase activity	0.8193600732138	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	0.74427062677768	bayes_pls_golite062009
lyase activity	0.129701662862796	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: