YRC Public Data Repository - Protein Structure Prediction

Protein:	METJ_ECOLI
Organism:	Escherichia coli
Length:	104 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METJ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|26250705, gi\|... - gi\|26250705\|ref\|NP_756745.1\| transcriptional repressor protein MetJ [Escherichia coli CFT073], gi\|26... gi\|218692222, gi... - gi\|218692222\|ref\|YP_002400434.1\| transcriptional repressor protein MetJ [Escherichia coli ED1a], gi\|...	227.0	[0..1]	[104..48]
gi\|218367774, gi... - gi\|218561005\|ref\|YP_002393918.1\| transcriptional repressor protein MetJ [Escherichia coli S88], gi\|2... gi\|218371343, gi... - gi\|218701357\|ref\|YP_002408986.1\| transcriptional repressor protein MetJ [Escherichia coli IAI39], gi... gi\|115515327, gi... - gi\|117626203\|ref\|YP_859526.1\| transcriptional repressor protein MetJ [Escherichia coli APEC O1], gi\|... gi\|91213480, gi\|... - gi\|91213480\|ref\|YP_543466.1\| transcriptional repressor protein MetJ [Escherichia coli UTI89], gi\|910... gi\|226902908, gi... - gi\|237702971\|ref\|ZP_04533452.1\| transcriptional repressor protein MetJ [Escherichia sp. 3_2_53FAA], ...	227.0	[0..1]	[104..48]
gi\|110617346, gi... - gi\|110807798\|ref\|YP_691318.1\| transcriptional repressor protein MetJ [Shigella flexneri 5 str. 8401]... gi\|24115232, gi\|... - ref\|NP_709742.1\| repressor of all met genes but metF [Shigella flexneri 2a str. 301], gb\|AAN45449.1...	218.0	[0..1]	[104..17]
METJ_PECCP - Met repressor OS=Pectobacterium carotovorum subsp. carotovorum (strain PC1) GN=metJ PE=3 SV=1 gi\|255056297, gi... - gi\|255056297\|ref\|ZP_05308514.1\| methionine repressor, MetJ [Pectobacterium wasabiae WPP163], gi\|2549... METJ_PECAS - Met repressor OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=metJ PE=3 SV=1 gi\|227113209 - gi\|227113209\|ref\|ZP_03826865.1\| transcriptional repressor protein MetJ [Pectobacterium carotovorum s... gi\|227327568 - gi\|227327568\|ref\|ZP_03831592.1\| transcriptional repressor protein MetJ [Pectobacterium carotovorum s... METJ_ERWCT - Met repressor OS=Erwinia carotovora subsp. atroseptica GN=metJ PE=3 SV=1	215.0	[0..1]	[104..2]
gi\|52426021, gi\|... - gi\|52426021\|ref\|YP_089158.1\| transcriptional repressor protein MetJ [Mannheimia succiniciproducens M...	214.0	[0..1]	[104..21]
METJ_KLEP7 - Met repressor OS=Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) GN=metJ PE... gi\|110180250 - gi\|110180250\|gb\|ABG54362.1\| transcriptional repressor [Klebsiella pneumoniae]	214.0	[0..1]	[104..2]
METJ_SALPC - Met repressor OS=Salmonella paratyphi C (strain RKS4594) GN=metJ PE=3 SV=1 gi\|214002252 - gi\|214002252\|ref\|ZP_03412987.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... gi\|213852560 - gi\|213852560\|ref\|ZP_03382092.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... gi\|213650488 - gi\|213650488\|ref\|ZP_03380541.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... METJ_SALEP - Met repressor OS=Salmonella enteritidis PT4 (strain P125109) GN=metJ PE=3 SV=1 METJ_SALG2 - Met repressor OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=metJ PE=3 SV=1 gi\|204930207, gi... - gi\|204930207\|ref\|ZP_03221184.1\| met repressor [Salmonella enterica subsp. enterica serovar Javiana s... gi\|200386747, gi... - gi\|200386747\|ref\|ZP_03213359.1\| met repressor [Salmonella enterica subsp. enterica serovar Virchow s... METJ_SALCH - Met repressor OS=Salmonella choleraesuis GN=metJ PE=3 SV=1 gi\|213620822 - gi\|213620822\|ref\|ZP_03373605.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... gi\|213580383 - gi\|213580383\|ref\|ZP_03362209.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... gi\|213052140 - gi\|213052140\|ref\|ZP_03345018.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... gi\|213021580 - gi\|213021580\|ref\|ZP_03336027.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... gi\|238912246 - gi\|238912246\|ref\|ZP_04656083.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. e... METJ_SALPB - Met repressor OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=metJ PE=3 SV=1 METJ_SALPA - Met repressor OS=Salmonella paratyphi A GN=metJ PE=3 SV=1 METJ_SALCH - Met repressor OS=Salmonella choleraesuis GN=metJ PE=3 SV=1 METJ_SALCH - Met repressor OS=Salmonella choleraesuis (strain SC-B67) GN=metJ PE=3 SV=1 METJ_SALTI - Met repressor OS=Salmonella typhi GN=metJ PE=3 SV=3 METJ_SALPA - Met repressor OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=metJ PE=3 SV=1 gi\|16762337 - gi\|16762337\|ref\|NP_457954.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. ente... METJ_SALTI - Met repressor OS=Salmonella typhi GN=metJ PE=3 SV=3 gi\|29139461, gi\|... - gi\|29143825\|ref\|NP_807167.1\| transcriptional repressor protein MetJ [Salmonella enterica subsp. ente... METJ_SALPB - Met repressor OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=metJ PE=3 SV=1 gi\|194471132, gi... - gi\|194471132\|ref\|ZP_03077116.1\| met repressor [Salmonella enterica subsp. enterica serovar Kentucky ... METJ_SALHS - Met repressor OS=Salmonella heidelberg (strain SL476) GN=metJ PE=3 SV=1 METJ_SALNS - Met repressor OS=Salmonella newport (strain SL254) GN=metJ PE=3 SV=1 gi\|205341822, gi... - gi\|205341822\|gb\|EDZ28586.1\| met repressor [Salmonella enterica subsp. enterica serovar Weltevreden s... METJ_SALDC - Met repressor OS=Salmonella dublin (strain CT_02021853) GN=metJ PE=3 SV=1 METJ_SALPK - Met repressor OS=Salmonella paratyphi A (strain AKU_12601) GN=metJ PE=3 SV=1 METJ_SALA4 - Met repressor OS=Salmonella agona (strain SL483) GN=metJ PE=3 SV=1 METJ_SALSV - Met repressor OS=Salmonella schwarzengrund (strain CVM19633) GN=metJ PE=3 SV=1 gi\|168233045, gi... - gi\|205332763\|gb\|EDZ19527.1\| met repressor [Salmonella enterica subsp. enterica serovar Kentucky str.... gi\|205323710, gi... - gi\|205323710\|gb\|EDZ11549.1\| met repressor [Salmonella enterica subsp. enterica serovar Saintpaul str... gi\|168467448, gi... - gi\|195630255\|gb\|EDX48895.1\| met repressor [Salmonella enterica subsp. enterica serovar Newport str. ... gi\|205348212, gi... - gi\|205348212\|gb\|EDZ34843.1\| met Apo-repressor, MetJ [Salmonella enterica subsp. enterica serovar Had... gi\|205336871, gi... - gi\|205336871\|gb\|EDZ23635.1\| met Apo-repressor, MetJ [Salmonella enterica subsp. enterica serovar Hei... gi\|197289438, gi... - gi\|197289438\|gb\|EDY28803.1\| met repressor [Salmonella enterica subsp. enterica serovar Schwarzengrun...	214.0	[0..1]	[104..2]
METJ_PHOLL - Met repressor OS=Photorhabdus luminescens subsp. laumondii GN=metJ PE=3 SV=1 METJ_PHOLL - Met repressor OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) GN...	214.0	[0..1]	[104..2]
gi\|217322693, gi... - gi\|217326472\|ref\|ZP_03442556.1\| met repressor [Escherichia coli O157:H7 str. TW14588], gi\|217322693\|... METJ_ECO27 - Met repressor OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=metJ PE=3 SV=1 METJ_ECO8A - Met repressor OS=Escherichia coli O8 (strain IAI1) GN=metJ PE=3 SV=1 METJ_ESCF3 - Met repressor OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) GN=metJ PE=3 S... METJ_ECO55 - Met repressor OS=Escherichia coli (strain 55989 / EAEC) GN=metJ PE=3 SV=1 METJ_ECOSM - Met repressor OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=metJ PE=3 SV=1 METJ_ECODH - Met repressor OS=Escherichia coli (strain K12 / DH10B) GN=metJ PE=3 SV=1 gi\|208808768, gi... - gi\|208808768\|ref\|ZP_03251105.1\| met repressor [Escherichia coli O157:H7 str. EC4206], gi\|208728569\|g... gi\|195937588 - gi\|195937588\|ref\|ZP_03082970.1\| transcriptional repressor protein MetJ [Escherichia coli O157:H7 str... gi\|208738943, gi... - gi\|208818820\|ref\|ZP_03259140.1\| met repressor [Escherichia coli O157:H7 str. EC4042], gi\|208738943\|g... gi\|208814162, gi... - gi\|208814162\|ref\|ZP_03255491.1\| met repressor [Escherichia coli O157:H7 str. EC4045], gi\|208735439\|g... METJ_ECOSE - Met repressor OS=Escherichia coli (strain SE11) GN=metJ PE=3 SV=1 METJ_ECO5E - Met repressor OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=metJ PE=3 SV=1 METJ_SHIFL - Met repressor OS=Shigella flexneri GN=metJ PE=3 SV=2 METJ_ECOLI - Met repressor (Met regulon regulatory protein metJ) - Escherichia coli gi\|30043029, gi\|... - gi\|30064769\|ref\|NP_838940.1\| transcriptional repressor protein MetJ [Shigella flexneri 2a str. 2457T... METJ_ECO57 - Met repressor OS=Escherichia coli O157:H7 GN=metJ PE=3 SV=2 EG10588 - transcriptional repressor, S-adenosylmethionine-binding / Methionine regulon repressor, SAM co-repre... gi\|15804535, gi\|... - gi\|15804535\|ref\|NP_290575.1\| transcriptional repressor protein MetJ [Escherichia coli O157:H7 EDL933... gi\|189357185, gi... - gi\|189357185\|gb\|EDU75604.1\| met repressor [Escherichia coli O157:H7 str. EC4401], gi\|168755632\|ref\|Z... gi\|168748756, gi... - gi\|188016805\|gb\|EDU54927.1\| met repressor [Escherichia coli O157:H7 str. EC4113], gi\|168748756\|ref\|Z... gi\|168768250, gi... - gi\|189362579\|gb\|EDU80998.1\| met repressor [Escherichia coli O157:H7 str. EC4486], gi\|168768250\|ref\|Z... gi\|189367849, gi... - gi\|189367849\|gb\|EDU86265.1\| met repressor [Escherichia coli O157:H7 str. EC4501], gi\|168761670\|ref\|Z... gi\|168780865, gi... - gi\|189001519\|gb\|EDU70505.1\| met repressor [Escherichia coli O157:H7 str. EC4076], gi\|168780865\|ref\|Z... gi\|13364343, gi\|... - gi\|15834121\|ref\|NP_312894.1\| transcriptional repressor protein MetJ [Escherichia coli O157:H7 str. S... gi\|168775218, gi... - gi\|187769219\|gb\|EDU33063.1\| met repressor [Escherichia coli O157:H7 str. EC4196], gi\|168775218\|ref\|Z... METJ_ECOL5 - Met repressor OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=metJ PE=3 SV=1 gi\|189378111, gi... - gi\|189378111\|gb\|EDU96527.1\| met repressor [Escherichia coli O157:H7 str. EC508], gi\|168799473\|ref\|ZP... gi\|168786804, gi... - gi\|189373429\|gb\|EDU91845.1\| met repressor [Escherichia coli O157:H7 str. EC869], gi\|168786804\|ref\|ZP... gi\|89110091, gi\|... - gi\|89110091\|ref\|AP_003871.1\| DNA-binding transcriptional repressor, S-adenosylmethionine-binding [Es... gi\|56480487, gi\|... - gi\|56480487\|ref\|NP_709742.2\| transcriptional repressor protein MetJ [Shigella flexneri 2a str. 301],... gi\|192929448, gi... - gi\|75258077\|ref\|ZP_00729538.1\| COG3060: Transcriptional regulator of met regulon [Escherichia coli E... gi\|188489405, gi... - gi\|75513875\|ref\|ZP_00736228.1\| COG3060: Transcriptional regulator of met regulon [Escherichia coli 5... gi\|193068018, gi... - gi\|75238384\|ref\|ZP_00722383.1\| COG3060: Transcriptional regulator of met regulon [Escherichia coli E... gi\|75240331, gi\|... - gi\|75240331\|ref\|ZP_00724271.1\| COG3060: Transcriptional regulator of met regulon [Escherichia coli F... METJ_SHIDS - Met repressor OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=metJ PE=3 SV=1 METJ_SHIBS - Met repressor OS=Shigella boydii serotype 4 (strain Sb227) GN=metJ PE=3 SV=1 METJ_SHISS - Met repressor OS=Shigella sonnei (strain Ss046) GN=metJ PE=3 SV=1 METJ_ECOL6 - Met repressor OS=Escherichia coli O6 GN=metJ PE=3 SV=2 gi\|194422745, gi... - gi\|83586217\|ref\|ZP_00924853.1\| COG3060: Transcriptional regulator of met regulon [Escherichia coli 1... METJ_SHIB3 - Met repressor OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=metJ PE=3 SV=1 gi\|124527603, gi... - gi\|124527603\|ref\|ZP_01699068.1\| methionine repressor, MetJ [Escherichia coli B], gi\|124501305\|gb\|EAY... gi\|194433241, gi... - gi\|83569793\|ref\|ZP_00921242.1\| COG3060: Transcriptional regulator of met regulon [Shigella dysenteri... gi\|194412560, gi... - gi\|75209375\|ref\|ZP_00709611.1\| COG3060: Transcriptional regulator of met regulon [Escherichia coli B... gi\|75227807, gi\|... - gi\|75227807\|ref\|ZP_00714525.1\| COG3060: Transcriptional regulator of met regulon [Escherichia coli B... METJ_ECOBW - Met repressor OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=metJ PE=3 SV=1 METJ_ECO24 - Met repressor OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=metJ PE=3 SV=1 gi\|251787202, gi... - gi\|251787202\|ref\|YP_003001506.1\| hypothetical protein B21_03773 [Escherichia coli BL21], gi\|24237947... METJ_ECOHS - Met repressor OS=Escherichia coli O9:H4 (strain HS) GN=metJ PE=3 SV=1 gi\|254290640, gi... - gi\|254290640\|ref\|YP_003056388.1\| transcriptional repressor protein MetJ [Escherichia coli BL21(DE3)]... gi\|254163889, gi... - gi\|254163889\|ref\|YP_003046997.1\| transcriptional repressor protein MetJ [Escherichia coli B str. REL... gi\|254795944, gi... - gi\|254795944\|ref\|YP_003080781.1\| DNA-binding transcriptional repressor, S-adenosylmethionine-binding... METJ_ECOLC - Met repressor OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=metJ PE=3 SV=1 EG10588 - transcriptional repressor, S-adenosylmethionine-binding / Methionine regulon repressor, SAM co-repre... sp\|B7UNQ8\|METJ_ECO27 - Met repressor OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=metJ PE=3 SV=1 METJ_ECOL6 - Met repressor OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=metJ PE=3 SV=2	213.0	[0..1]	[104..2]
gi\|238764485, gi... - gi\|238764485\|ref\|ZP_04625433.1\| Met repressor [Yersinia kristensenii ATCC 33638], gi\|238697297\|gb\|EE... METJ_YERE8 - Met repressor OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) GN=met... METJ_YERPY - Met repressor OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=metJ PE=3 SV=1 METJ_YERPS - Met repressor OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=metJ PE=3 SV=1 METJ_YERPB - Met repressor OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=metJ PE=3 SV=1 tr\|I0QQY2\|I0QQY2... - Met repressor OS=Serratia sp. M24T3 GN=metJ PE=3 SV=1 gi\|77976267 - gi\|77976267\|ref\|ZP_00831772.1\| COG3060: Transcriptional regulator of met regulon [Yersinia intermedi... gi\|238789603, gi... - gi\|77972984\|ref\|ZP_00828538.1\| COG3060: Transcriptional regulator of met regulon [Yersinia frederiks... gi\|77960052, gi\|... - gi\|77960052\|ref\|ZP_00823950.1\| COG3060: Transcriptional regulator of met regulon [Yersinia mollareti... gi\|238712829, gi... - gi\|77956368\|ref\|ZP_00820473.1\| COG3060: Transcriptional regulator of met regulon [Yersinia bercovier... METJ_YERP3 - Met repressor OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=metJ PE=3 SV=1 METJ_YERPS - Met repressor OS=Yersinia pseudotuberculosis GN=metJ PE=3 SV=1 gi\|238701436, gi... - gi\|238760308\|ref\|ZP_04621450.1\| Met repressor [Yersinia aldovae ATCC 35236], gi\|238701436\|gb\|EEP9401... gi\|238750852, gi... - gi\|238750852\|ref\|ZP_04612350.1\| Met repressor [Yersinia rohdei ATCC 43380], gi\|238710996\|gb\|EEQ03216...	213.0	[0..1]	[104..2]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEWSGEYISP YAEHGKKSEQ VKKITVSIPL KVLKILTDER TRRQVNNLRH ATNSELLCEA  60
   61 FLHAFTGQPL PDDADLRKER SDEIPEAAKE IMREMGINPE TWEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.0
Match:	1cmaA
Description:	Met repressor, MetJ (MetR)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.04550805527064	bayes_pls_golite062009
nucleic acid binding	1.64041161776156	bayes_pls_golite062009
DNA binding	1.63454845002469	bayes_pls_golite062009
transcription factor activity	1.51901839861349	bayes_pls_golite062009
binding	0.930860104386556	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: