YRC Public Data Repository - Protein Structure Prediction

Protein:	LLDD_ECOLI
Organism:	Escherichia coli
Length:	396 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LLDD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|114769269, gi... - gi\|114769269\|ref\|ZP_01446895.1\| L-lactate dehydrogenase, putative [alpha proteobacterium HTCC2255], ... gi\|114769269 - gi\|114769269\|ref\|ZP_01446895.1\| L-lactate dehydrogenase, putative [alpha proteobacterium HTCC2255]	358.0	[0..2]	[385..3]
gi\|25284064, gi\|... - pir\|\|AE2861 L-lactate dehydrogenase lldA [imported] - Agrobacterium tumefaciens (strain C58, Dupont)... gi\|17936201, gi\|... - gi\|17936201\|ref\|NP_532991.1\| L-lactate dehydrogenase [Agrobacterium tumefaciens str. C58], gi\|177407...	357.0	[0..3]	[376..9]
gi\|254690761 - gi\|254690761\|ref\|ZP_05154015.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella abortus bv.... gi\|254698540 - gi\|254698540\|ref\|ZP_05160368.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella abortus bv.... gi\|23500647, gi\|... - gi\|23500647\|ref\|NP_700087.1\| L-lactate dehydrogenase [Brucella suis 1330], gi\|23464291\|gb\|AAN34092.1... gi\|83269235 - gi\|83269235\|ref\|YP_418526.1\| FMN-dependent alpha-hydroxy acid dehydrogenase:FMN/related compound-bin... gi\|163845035, gi... - gi\|163845035\|ref\|YP_001622690.1\| hypothetical protein BSUIS_B0912 [Brucella suis ATCC 23445], gi\|163... gi\|254710846 - gi\|254710846\|ref\|ZP_05172657.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella pinnipedial... gi\|62197447, gi\|... - gi\|62317254\|ref\|YP_223107.1\| LldD, L-lactate dehydrogenase [Brucella abortus bv. 1 str. 9-941], gi\|6... gi\|189021089, gi... - gi\|189022515\|ref\|YP_001932256.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella abortus S1... gi\|254720217 - gi\|254720217\|ref\|ZP_05182028.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella sp. 83/13] gi\|82939509 - gi\|82939509\|emb\|CAJ12481.1\| FMN-dependent alpha-hydroxy acid dehydrogenase:FMN/related compound-bind... gi\|254703239 - gi\|254703239\|ref\|ZP_05165067.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella suis bv. 3 ... gi\|148558478, gi... - gi\|148558478\|ref\|YP_001257841.1\| L-lactate dehydrogenase [Brucella ovis ATCC 25840], gi\|148369763\|gb... gi\|254705616 - gi\|254705616\|ref\|ZP_05167444.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella pinnipedial... gi\|254731987 - gi\|254731987\|ref\|ZP_05190565.1\| FMN-dependent alpha-hydroxy acid dehydrogenase [Brucella abortus bv.... gi\|161620972, gi... - gi\|161620972\|ref\|YP_001594858.1\| L-lactate dehydrogenase (cytochrome) [Brucella canis ATCC 23365], g...	357.0	[0..3]	[375..4]
gi\|17988722, gi\|... - gi\|17988722\|ref\|NP_541355.1\| L-lactate dehydrogenase (cytochrome) [Brucella melitensis 16M], gi\|1798... gi\|25284067 - pir\|\|AH3556 l-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) [imported] - Brucella melitensis (stra...	355.0	[0..3]	[375..5]
gi\|121635083, gi... - gi\|121635083\|ref\|YP_975328.1\| L-lactate dehydrogenase [Neisseria meningitidis FAM18], gi\|120866789\|e... gi\|1381737 - gi\|1381737\|gb\|AAB09666.1\| lactate dehydrogenase gi\|15677240, gi\|... - gi\|7413460\|gb\|AAF62327.1\| L-lactate dehydrogenase [Neisseria meningitidis MC58], gi\|15677240\|ref\|NP_...	355.0	[0..3]	[386..8]
gi\|11251817 - pir\|\|C81852 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) NMA1592 [imported] - Neisseria meningi... gi\|121052402, gi... - gi\|7380233\|emb\|CAB84819.1\| L-lactate dehydrogenase [Neisseria meningitidis Z2491], gi\|218768394\|ref\|... gi\|161870249, gi... - gi\|161870249\|ref\|YP_001599419.1\| L-lactate dehydrogenase [Neisseria meningitidis 053442], gi\|1615958...	355.0	[0..3]	[386..8]
gi\|71039194, gi\|... - gi\|71066209\|ref\|YP_264936.1\| L-lactate dehydrogenase (cytochrome) [Psychrobacter arcticus 273-4], gi...	354.0	[0..3]	[388..7]
gi\|89082222, gi\|... - gi\|89093532\|ref\|ZP_01166480.1\| putative L-lactate dehydrogenase (cytochrome) protein [Oceanospirillu...	351.0	[0..2]	[371..3]
gi\|116253321, gi... - gi\|116253321\|ref\|YP_769159.1\| putative L-lactate dehydrogenase [Rhizobium leguminosarum bv. viciae 3...	351.0	[0..2]	[375..3]
gi\|71364763, gi\|... - gi\|93006713\|ref\|YP_581150.1\| L-lactate dehydrogenase (cytochrome) [Psychrobacter cryohalolentis K5],...	351.0	[0..3]	[388..7]

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Predicted Domain #1

Region A:
Residues: [1-396]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIISAASDYR AAAQRILPPF LFHYMDGGAY SEYTLRRNVE DLSEVALRQR ILKNMSDLSL  60
   61 ETTLFNEKLS MPVALAPVGL CGMYARRGEV QAAKAADAHG IPFTLSTVSV CPIEEVAPAI 120
  121 KRPMWFQLYV LRDRGFMRNA LERAKAAGCS TLVFTVDMPT PGARYRDAHS GMSGPNAAMR 180
  181 RYLQAVTHPQ WAWDVGLNGR PHDLGNISAY LGKPTGLEDY IGWLGNNFDP SISWKDLEWI 240
  241 RDFWDGPMVI KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGD 300
  301 IAILADSGIR NGLDVVRMIA LGADTVLLGR AFLYALATAG QAGVANLLNL IEKEMKVAMT 360
  361 LTGAKSISEI TQDSLVQGLG KELPAALAPM AKGNAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.522879
Match:	1al7A
Description:	THREE-DIMENSIONAL STRUCTURES OF GLYCOLATE OXIDASE WITH BOUND ACTIVE-SITE INHIBITORS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on the CH-CH group of donors	5.53040931722074	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4.99876306143789	bayes_pls_golite062009
L-lactate dehydrogenase (cytochrome) activity	4.62364477397179	bayes_pls_golite062009
lactate dehydrogenase activity	4.48836665081946	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor	4.26416137128289	bayes_pls_golite062009
oxidoreductase activity	3.55520438339582	bayes_pls_golite062009
2,4-dienoyl-CoA reductase (NADPH) activity	2.53740821102118	bayes_pls_golite062009
catalytic activity	1.94749091175302	bayes_pls_golite062009
binding	1.13068993839107	bayes_pls_golite062009
(S)-2-hydroxy-acid oxidase activity	1.08257847863105	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	0.922853827985629	bayes_pls_golite062009
NADH dehydrogenase activity	0.449365788564188	bayes_pls_golite062009
nucleic acid binding	0.428925551338656	bayes_pls_golite062009
protein binding	0.174608759343963	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	0.0276574257865798	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: