YRC Public Data Repository - Protein Structure Prediction

Protein:	KDPE_ECOLI
Organism:	Escherichia coli
Length:	225 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KDPE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|83588943, gi\|... - gi\|83588943\|ref\|YP_428952.1\| two component transcriptional regulator [Moorella thermoacetica ATCC 39...	256.0	[0..1]	[223..4]
gi\|98660701 - gi\|98660701\|dbj\|GAA02123.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	255.0	[0..2]	[225..105]
gi\|48860348, gi\|... - gi\|67873291\|ref\|ZP_00503570.1\| Response regulator receiver:Transcriptional regulatory protein, C ter...	249.0	[0..2]	[225..5]
gi\|28209958, gi\|... - gi\|28209958\|ref\|NP_780902.1\| transcriptional regulatory protein [Clostridium tetani E88], gi\|2820239...	248.0	[0..2]	[225..24]
gi\|106766772, gi... - gi\|160880093\|ref\|YP_001559061.1\| two component transcriptional regulator [Clostridium phytofermentan...	247.0	[0..2]	[223..3]
gi\|4982229, gi\|1... - gi\|4982229\|gb\|AAD36722.1\|AE001807_13 response regulator DrrA [Thermotoga maritima MSB8], gi\|15644403... gi\|7444020 - pir\|\|D72228 response regulator DrrA - Thermotoga maritima (strain MSB8)	247.0	[0..2]	[223..12]
gi\|82403020, gi\|... - gi\|82499006\|ref\|ZP_00884459.1\| Response regulator receiver [Caldicellulosiruptor saccharolyticus DSM...	247.0	[0..2]	[223..4]
gi\|134051275, gi... - gi\|88945490\|ref\|ZP_01148660.1\| Response regulator receiver [Desulfotomaculum reducens MI-1], gi\|8892...	247.0	[0..1]	[223..1]
gi\|10175779, gi\|... - gi\|15615719\|ref\|NP_244023.1\| two-component response regulator involved in phosphate regulation [Baci... gi\|25300880 - pir\|\|E84044 two-component response regulator involved in phosphate regulation phoP [imported] - Baci...	247.0	[0..3]	[224..4]

Back

Predicted Domain #1

Region A:
Residues: [1-124]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNVLIVEDE QAIRRFLRTA LEGDGMRVFE AETLQRGLLE AATRKPDLII LDLGLPDGDG  60
   61 IEFIRDLRQW SAVPVIVLSA RSEESDKIAA LDAGADDYLS KPFGIGELQA RLRVALRRHS 120
  121 ATTA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.09691
Match:	1zh2A
Description:	Crystal Structure Of The Calcium-Bound Receiver Domain Of Kdp Potassium Transport System Response Regulator KdpE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	7.02872640261738	bayes_pls_golite062009
transcription regulator activity	5.23016166796951	bayes_pls_golite062009
signal transducer activity	4.51666042720644	bayes_pls_golite062009
molecular transducer activity	4.51666042720644	bayes_pls_golite062009
DNA binding	2.75354350283069	bayes_pls_golite062009
nucleic acid binding	2.67056525675208	bayes_pls_golite062009
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
transcription factor activity	2.12579037300919	bayes_pls_golite062009
binding	1.22427537074115	bayes_pls_golite062009
protein kinase activity	1.00737355751913	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.811771244977462	bayes_pls_golite062009
kinase activity	0.725824770559857	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.476057209677045	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [125-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDPLVKFSDV TVDLAARVIH RGEEEVHLTP IEFRLLAVLL NNAGKVLTQR QLLNQVWGPN  60
   61 AVEHSHYLRI YMGHLRQKLE QDPARPRHFI TETGIGYRFM L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.522879
Match:	2d1vA
Description:	No description for 2d1vA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: