YRC Public Data Repository - Protein Structure Prediction

Protein:	KBL_ECOLI
Organism:	Escherichia coli
Length:	398 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KBL_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|85695191, gi\|... - gi\|85710787\|ref\|ZP_01041848.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Idiomarina baltica OS145], ...	382.0	[0..1]	[397..1]
gi\|89889934, gi\|... - gi\|89889934\|ref\|ZP_01201445.1\| glycine C-acetyltransferase (2-amino-3-ketobutyrate CoA ligase) [Flav...	377.0	[0..1]	[398..1]
gi\|86131068, gi\|... - gi\|86131068\|ref\|ZP_01049667.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Cellulophaga sp. MED134], g...	373.0	[0..1]	[397..1]
gi\|77972947 - gi\|77972947\|ref\|ZP_00828501.1\| COG0156: 7-keto-8-aminopelargonate synthetase and related enzymes [Ye...	371.0	[0..3]	[398..32]
gi\|77961967, gi\|... - gi\|77961967\|ref\|ZP_00825794.1\| COG0156: 7-keto-8-aminopelargonate synthetase and related enzymes [Ye...	371.0	[0..3]	[398..8]
gi\|56178391, gi\|... - gi\|56459381\|ref\|YP_154662.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Idiomarina loihiensis L2TR], ...	371.0	[0..1]	[397..1]
gi\|77958470 - gi\|77958470\|ref\|ZP_00822503.1\| COG0156: 7-keto-8-aminopelargonate synthetase and related enzymes [Ye...	370.0	[0..3]	[398..8]
gi\|86135194, gi\|... - gi\|86135194\|ref\|ZP_01053776.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Polaribacter sp. MED152], g...	369.0	[0..1]	[397..1]
gi\|162418575, gi... - gi\|162418575\|ref\|YP_001604705.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Yersinia pestis Angola], ... gi\|166213652, gi... - gi\|166213652\|ref\|ZP_02239687.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Yersinia pestis biovar Ant... gi\|165989634, gi... - gi\|166011488\|ref\|ZP_02232386.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Yersinia pestis biovar Ant... gi\|89103909 - gi\|89103909\|ref\|ZP_01176469.1\| COG0156: 7-keto-8-aminopelargonate synthetase and related enzymes [Ye... gi\|167426686, gi... - gi\|167426686\|ref\|ZP_02318439.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Yersinia pestis biovar Med... gi\|167048091, gi... - gi\|167402536\|ref\|ZP_02307986.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Yersinia pestis biovar Ant... gi\|22124001, gi\|... - gi\|22124001\|ref\|NP_667424.1\| 2-amino-3-ketobutyrate coenzyme A ligase [Yersinia pestis KIM], gi\|2195...	368.0	[0..3]	[398..18]
gi\|152960072, gi... - gi\|77630863\|ref\|ZP_00793449.1\| COG0156: 7-keto-8-aminopelargonate synthetase and related enzymes [Ye...	367.0	[0..4]	[398..9]

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Predicted Domain #1

Region A:
Residues: [1-398]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGEFYQQLT NDLETARAEG LFKEERIITS AQQADITVAD GSHVINFCAN NYLGLANHPD  60
   61 LIAAAKAGMD SHGFGMASVR FICGTQDSHK ELEQKLAAFL GMEDAILYSS CFDANGGLFE 120
  121 TLLGAEDAII SDALNHASII DGVRLCKAKR YRYANNDMQE LEARLKEARE AGARHVLIAT 180
  181 DGVFSMDGVI ANLKGVCDLA DKYDALVMVD DSHAVGFVGE NGRGSHEYCD VMGRVDIITG 240
  241 TLGKALGGAS GGYTAARKEV VEWLRQRSRP YLFSNSLAPA IVAASIKVLE MVEAGSELRD 300
  301 RLWANARQFR EQMSAAGFTL AGADHAIIPV MLGDAVVAQK FARELQKEGI YVTGFFYPVV 360
  361 PKGQARIRTQ MSAAHTPEQI TRAVEAFTRI GKQLGVIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	100.0
Match:	1fc4A
Description:	2-amino-3-ketobutyrate CoA ligase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
5-aminolevulinate synthase activity	3.15163480353521	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	2.82458180884712	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
N-succinyltransferase activity	1.81799375593294	bayes_pls_golite062009
threonine aldolase activity	1.80396420390785	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	1.74778109525713	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	1.63055151623667	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	1.63055151623667	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
glycine C-acetyltransferase activity	0.935794708043259	bayes_pls_golite062009
transferase activity	0.737426388870721	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups	0.659071155545801	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.319452731970428	bayes_pls_golite062009
cystathionine beta-lyase activity	0.15938456446406	bayes_pls_golite062009
sulfurtransferase activity	0.0450490929307473	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: