YRC Public Data Repository - Protein Structure Prediction

Protein:	K6P1_ECOLI, K6PF...
Organism:	Escherichia coli
Length:	320 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for K6P1_ECOLI, K6PF....

Description	E-value	Query Range	Subject Range
K6PF_ERWCT - 6-phosphofructokinase OS=Erwinia carotovora subsp. atroseptica GN=pfkA PE=3 SV=1 PFKA_PECAS - ATP-dependent 6-phosphofructokinase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)...	411.0	[0..1]	[320..1]
gi\|26111112, gi\|... - gi\|26250681\|ref\|NP_756721.1\| 6-phosphofructokinase [Escherichia coli CFT073], gi\|26111112\|gb\|AAN8329...	410.0	[0..1]	[320..33]
gi\|117626183, gi... - gi\|117626183\|ref\|YP_859506.1\| 6-phosphofructokinase [Escherichia coli APEC O1], gi\|115515307\|gb\|ABJ0... gi\|110807394, gi... - gi\|110807394\|ref\|YP_690914.1\| 6-phosphofructokinase [Shigella flexneri 5 str. 8401], gi\|110616942\|gb...	410.0	[0..1]	[320..21]
gi\|91075030, gi\|... - gi\|91213456\|ref\|YP_543442.1\| 6-phosphofructokinase [Escherichia coli UTI89], gi\|91075030\|gb\|ABE09911... gi\|226902884, gi... - gi\|237702947\|ref\|ZP_04533428.1\| 6-phosphofructokinase isozyme I [Escherichia sp. 3_2_53FAA], gi\|2269...	409.0	[0..1]	[320..33]
PFKA_ECOL6 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928... PFKA_ECO27 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) G... sp\|B7UNN6\|K6PF_ECO27 - 6-phosphofructokinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=pfkA PE=3 SV=1 K6PF1_ECOL6, K6P... - (Q8FBD0) 6-phosphofructokinase (EC 2.7.1.11) (Phosphofructokinase) (Phosphohexokinase), 6-phosphofru...	408.0	[0..1]	[320..1]
PFKA_ENTCL - ATP-dependent 6-phosphofructokinase OS=Enterobacter cloacae GN=pfkA PE=3 SV=1	407.0	[0..1]	[320..1]
gi\|11259236 - gi\|11259236\|pir\|\|G82045 6-phosphofructokinase, isozyme I VC2689 [imported] - Vibrio cholerae (strain... gi\|197752636, gi... - gi\|254285879\|ref\|ZP_04960841.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae AM-19226], gi\|1977... gi\|153829467, gi... - gi\|153829467\|ref\|ZP_01982134.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae 623-39], gi\|148875... gi\|153825091, gi... - gi\|153825091\|ref\|ZP_01977758.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae MZO-2], gi\|1497412... gi\|227014577, gi... - gi\|227119127\|ref\|YP_002821023.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae O395], gi\|2270145... gi\|9657284, gi\|1... - gi\|9657284\|gb\|AAF95830.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae O1 biovar El Tor str. N1... gi\|227010693, gi... - gi\|227082805\|ref\|YP_002811356.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae M66-2], gi\|227010... gi\|121729840, gi... - gi\|121729840\|ref\|ZP_01682272.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae V52], gi\|121628419... gi\|121546535, gi... - gi\|121591612\|ref\|ZP_01678861.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae 2740-80], gi\|12154... gi\|153221038, gi... - gi\|153221038\|ref\|ZP_01952093.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae MAK 757], gi\|12411... gi\|153212537, gi... - gi\|153212537\|ref\|ZP_01948284.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae 1587], gi\|12411640... gi\|254851225, gi... - gi\|254851225\|ref\|ZP_05240575.1\| 6-phosphofructokinase [Vibrio cholerae MO10], gi\|254846930\|gb\|EET253... gi\|124121047, gi... - gi\|153803414\|ref\|ZP_01958000.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae MZO-3], gi\|1241210... gi\|153820303, gi... - gi\|153820303\|ref\|ZP_01972970.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae NCTC 8457], gi\|126... gi\|194537437, gi... - gi\|254225416\|ref\|ZP_04919027.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae V51], gi\|194537437... gi\|126518420, gi... - gi\|153824056\|ref\|ZP_01976723.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae B33], gi\|126518420...	406.0	[0..1]	[320..12]
gi\|194471419, gi... - gi\|194471419\|ref\|ZP_03077403.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar K... PFKA_SALHS - ATP-dependent 6-phosphofructokinase OS=Salmonella heidelberg (strain SL476) GN=pfkA PE=3 SV=1 PFKA_SALNS - ATP-dependent 6-phosphofructokinase OS=Salmonella newport (strain SL254) GN=pfkA PE=3 SV=1 gi\|205341858, gi... - gi\|205341858\|gb\|EDZ28622.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Welte... PFKA_SALPK - ATP-dependent 6-phosphofructokinase OS=Salmonella paratyphi A (strain AKU_12601) GN=pfkA PE=3 SV=1 PFKA_SALCH - ATP-dependent 6-phosphofructokinase OS=Salmonella choleraesuis (strain SC-B67) GN=pfkA PE=3 SV=1 K6PF_SALPB - 6-phosphofructokinase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=pfkA PE=3 SV=1 gi\|197243067, gi... - gi\|197264812\|ref\|ZP_03164886.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar S... PFKA_SALPA - ATP-dependent 6-phosphofructokinase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=pfkA PE... K6PF_SALPA - 6-phosphofructokinase OS=Salmonella paratyphi A GN=pfkA PE=3 SV=1 PFKA_SALA4 - ATP-dependent 6-phosphofructokinase OS=Salmonella agona (strain SL483) GN=pfkA PE=3 SV=1 K6PF_SALCH - 6-phosphofructokinase OS=Salmonella choleraesuis GN=pfkA PE=3 SV=1 PFKA_SALSV - ATP-dependent 6-phosphofructokinase OS=Salmonella schwarzengrund (strain CVM19633) GN=pfkA PE=3 SV=1 gi\|168233002, gi... - gi\|205332776\|gb\|EDZ19540.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Kentu... gi\|205329981, gi... - gi\|205329981\|gb\|EDZ16745.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar 4,[5]... gi\|167551446, gi... - gi\|205323746\|gb\|EDZ11585.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Saint... gi\|168467403, gi... - gi\|195630159\|gb\|EDX48799.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Newpo... gi\|205348278, gi... - gi\|205348278\|gb\|EDZ34909.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Hadar... gi\|168244185, gi... - gi\|205336900\|gb\|EDZ23664.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Heide... gi\|197289375, gi... - gi\|197289375\|gb\|EDY28740.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Schwa... PFKA_SALTY - ATP-dependent 6-phosphofructokinase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) ... gi\|29139496, gi\|... - gi\|29143860\|ref\|NP_807202.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Typh... PFKA_SALTI - ATP-dependent 6-phosphofructokinase OS=Salmonella typhi GN=pfkA PE=3 SV=1 PFKA_SALPC - ATP-dependent 6-phosphofructokinase OS=Salmonella paratyphi C (strain RKS4594) GN=pfkA PE=3 SV=1 gi\|16762372 - gi\|16762372\|ref\|NP_457989.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar Typh... PFKA_SALEP - ATP-dependent 6-phosphofructokinase OS=Salmonella enteritidis PT4 (strain P125109) GN=pfkA PE=3 SV=1 gi\|204930287, gi... - gi\|204930287\|ref\|ZP_03221264.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar J... gi\|199604552, gi... - gi\|200387454\|ref\|ZP_03214066.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar V... PFKA_SALDC - ATP-dependent 6-phosphofructokinase OS=Salmonella dublin (strain CT_02021853) GN=pfkA PE=3 SV=1 gi\|214001102 - gi\|214001102\|ref\|ZP_03411837.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar T... gi\|238912207 - gi\|238912207\|ref\|ZP_04656044.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar T... PFKA_SALPB - ATP-dependent 6-phosphofructokinase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=pfkA ... gi\|213645951 - gi\|213645951\|ref\|ZP_03376004.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar T... gi\|213426107 - gi\|213426107\|ref\|ZP_03358857.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar T... gi\|213052745 - gi\|213052745\|ref\|ZP_03345623.1\| 6-phosphofructokinase [Salmonella enterica subsp. enterica serovar T... K6PF_SALTI - 6-phosphofructokinase OS=Salmonella typhi GN=pfkA PE=3 SV=1 K6PF_SALTY - 6-phosphofructokinase OS=Salmonella typhimurium GN=pfkA PE=3 SV=1 K6PF_SALCH - 6-phosphofructokinase OS=Salmonella choleraesuis GN=pfkA PE=3 SV=1 PFKA_SALAR - ATP-dependent 6-phosphofructokinase OS=Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK298... K6PF_SALTY - 6-phosphofructokinase OS=Salmonella typhimurium GN=pfkA PE=3 SV=1 lcl\|NC_016856.1_... - [gene=pfkA] [protein=6-phosphofructokinase] [protein_id=YP_005240338.1] [location=4285914..4286876]	406.0	[0..1]	[320..1]
gi\|229331701, gi... - gi\|229497223\|ref\|ZP_04390924.1\| 6-phosphofructokinase [Geobacillus sp. Y412MC52], gi\|229331701\|gb\|EE... gi\|220707901, gi... - gi\|221088139\|ref\|ZP_03557672.1\| 6-phosphofructokinase [Geobacillus sp. Y412MC61], gi\|220707901\|gb\|EE... PFKA_GEOKA - ATP-dependent 6-phosphofructokinase OS=Geobacillus kaustophilus (strain HTA426) GN=pfkA PE=3 SV=1 K6PF_GEOKA - 6-phosphofructokinase OS=Geobacillus kaustophilus GN=pfkA PE=3 SV=1	406.0	[0..2]	[319..1]
PFKA_VIBCH - ATP-dependent 6-phosphofructokinase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba... gi\|116221049, gi... - gi\|75819872\|ref\|ZP_00749935.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae V51], gi\|116221049\|re... gi\|75814340 - gi\|75814340\|ref\|ZP_00744943.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae V52] K6PF_VIBCH - 6-phosphofructokinase OS=Vibrio cholerae GN=pfkA PE=3 SV=2 gi\|75830102, gi\|... - gi\|75830102\|ref\|ZP_00759387.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae MO10], gi\|116190677\|r... gi\|75827932 - gi\|75827932\|ref\|ZP_00757367.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae O395]	405.0	[0..1]	[320..1]

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Predicted Domain #1

Region A:
Residues: [1-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKKIGVLTS GGDAPGMNAA IRGVVRSALT EGLEVMGIYD GYLGLYEDRM VQLDRYSVSD  60
   61 MINRGGTFLG SARFPEFRDE NIRAVAIENL KKRGIDALVV IGGDGSYMGA MRLTEMGFPC 120
  121 IGLPGTIDND IKGTDYTIGF FTALSTVVEA IDRLRDTSSS HQRISVVEVM GRYCGDLTLA 180
  181 AAIAGGCEFV VVPEVEFSRE DLVNEIKAGI AKGKKHAIVA ITEHMCDVDE LAHFIEKETG 240
  241 RETRATVLGH IQRGGSPVPY DRILASRMGA YAIDLLLAGY GGRCVGIQNE QLVHHDIIDA 300
  301 IENMKRPFKG DWLDCAKKLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.0
Match:	1pfkA
Description:	ATP-dependent phosphofructokinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
6-phosphofructokinase activity	12.7403693686468	bayes_pls_golite062009
phosphofructokinase activity	11.7059647240147	bayes_pls_golite062009
carbohydrate kinase activity	9.54757838113048	bayes_pls_golite062009
fructose-6-phosphate binding	7.12870468168491	bayes_pls_golite062009
fructose binding	7.0070117394116	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.40595318732289	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.20407391743017	bayes_pls_golite062009
kinase activity	2.09076306615481	bayes_pls_golite062009
transferase activity	1.97789134877808	bayes_pls_golite062009
catalytic activity	1.89212073381079	bayes_pls_golite062009
monosaccharide binding	0.93954836516667	bayes_pls_golite062009
binding	0.692710585652872	bayes_pls_golite062009
hydrolase activity	0.276140444059183	bayes_pls_golite062009
fructose-2,6-bisphosphate 2-phosphatase activity	0.13423626204854	bayes_pls_golite062009
sugar binding	0.0026978348896064	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: