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View Structure Prediction Details

Protein: INSG_ECOLI
Organism: Escherichia coli
Length: 442 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INSG_ECOLI.

Description E-value Query
Range
Subject
Range
gi|30064967, gi|... - gi|30064967|ref|NP_839138.1| IS4 orf [Shigella flexneri 2a str. 2457T], gi|30043228|gb|AAP18949.1| I...
383.0 [0..1] [442..1]
gi|24114080, gi|... - gi|24114080|ref|NP_708590.1| IS4 orf [Shigella flexneri 2a str. 301], gi|24053208|gb|AAN44297.1| IS4...
383.0 [0..1] [442..7]
gi|58045007, gi|... - gi|58045007|gb|AAW64777.1| IS4 ORF [Shigella flexneri], gi|13448961|ref|NP_085177.1| IS4 orf [Shigel...
gi|13310509|gb|A... - IS4 orf [Shigella flexneri]
gi|24051787, gi|... - gi|24112849|ref|NP_707359.1| IS4 orf [Shigella flexneri 2a str. 301], gi|24051787|gb|AAN43066.1| IS4...
gi|110805439, gi... - gi|110805439|ref|YP_688959.1| IS4 orf [Shigella flexneri 5 str. 8401], gi|110804254|ref|YP_687774.1|...
382.0 [0..1] [442..7]
gi|110617575, gi... - gi|110808027|ref|YP_691547.1| IS4 orf [Shigella flexneri 5 str. 8401], gi|110617575|gb|ABF06242.1| I...
382.0 [0..1] [442..7]
gi|83571141 - gi|83571141|ref|ZP_00922582.1| COG3385: FOG: Transposase and inactivated derivatives [Shigella dysen...
gi|75175824, gi|... - gi|75178404|ref|ZP_00698458.1| COG3385: FOG: Transposase and inactivated derivatives [Shigella boydi...
382.0 [0..1] [442..1]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHIGQALDLV SRYDSLRNPL TSLGDYLDPE LISRCLAESG TVTLRKRRLP LEMMVWCIVG  60
   61 MALERKEPLH QIVNRLDIML PGNRPFVAPS AVIQARQRLG SEAVRRVFTK TAQLWHNATP 120
  121 HPHW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [125-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGLTLLAIDG VFWRTPDTPE NDAAFPRQTH AGNPALYPQV KMVCQMELTS HLLTAAAFGT  60
   61 MKNSENELAE QLIEQTGDNT LTLMDKGYYS LGLLNAWSLA GEHRHWMIPL RKGAQYEEIR 120
  121 KLGKGDHLVK LKTSPQARKK WPGLGNEVTA RLLTVTRKGK VCHLLTSMTD AMRFPGGEMG 180
  181 DLYSHRWEIE LGYREIKQTM QRSRLTLRSK KPELVEQELW GVLLAYNLVR YQMIKMAEHL 240
  241 KGYWPNQLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1murA
Description: Transposase inhibitor (Tn5 transposase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 1.81796593394339 bayes_pls_golite062009
exonuclease activity 1.64964907710028 bayes_pls_golite062009
catalytic activity 1.62277843225829 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.58702937619673 bayes_pls_golite062009
hydrolase activity 1.41857676124086 bayes_pls_golite062009
transposase activity 1.09803761537443 bayes_pls_golite062009
ribonuclease activity 0.71352601607444 bayes_pls_golite062009
deoxyribonuclease activity 0.63299586096139 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.62821439153618 bayes_pls_golite062009
endonuclease activity 0.150927275899469 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [374-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSESCGMVMR MLMTLQGASP GRIPELMRDL ASMGQLVKLP TRRERAFPRV VKERPWKYPT  60
   61 APKKSQSVA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle