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View Structure Prediction Details

Protein: IL4_PANTR
Organism: Pan troglodytes
Length: 153 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IL4_PANTR.

Description E-value Query
Range
Subject
Range
gi|55624750, gi|... - ref|XP_517924.1| PREDICTED: similar to interleukin 4 [Pan troglodytes], gi|39980475|gb|AAR32990.1| ...
8.0E-61 [1..153] [1..153]
gi|60828589, gi|... - gi|61368531|gb|AAX43196.1| interleukin 4 [synthetic construct], gi|60828589|gb|AAX36848.1| interleuk...
1.0E-60 [1..153] [1..153]
gi|42490871 - gi|42490871|gb|AAH66277.1| Interleukin 4, isoform 1 precursor [Homo sapiens]
2.0E-60 [1..153] [1..153]
IL4_MACFA - Interleukin-4 OS=Macaca fascicularis GN=IL4 PE=2 SV=2
2.0E-59 [1..153] [1..153]
IL4_MACMU - Interleukin-4 OS=Macaca mulatta GN=IL4 PE=2 SV=1
3.0E-58 [1..153] [1..153]
IL4_CERAT - Interleukin-4 OS=Cercocebus atys GN=IL4 PE=2 SV=1
gi|644794 - gi|644794|gb|AAB60396.1| interleukin-4
5.0E-58 [1..153] [1..153]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS  60
   61 KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL 120
  121 NSCPVKEANQ STLENFLERL KTIMREKYSK CSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.69897
Match: 1itlA
Description: HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
cytokine activity 6.38439864086716 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
interleukin-10 receptor binding 3.27756723691542 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
interleukin-4 receptor binding 3.17951022946458 bayes_pls_golite062009
growth hormone activity 2.71439518801599 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
hormone activity 2.25587306265428 bayes_pls_golite062009
interleukin-12 binding 2.17594406686308 bayes_pls_golite062009
interleukin-27 binding 1.83998174953013 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.79326213321183 bayes_pls_golite062009
interleukin-2 receptor binding 1.24568403220915 bayes_pls_golite062009
interleukin-12 beta subunit binding 1.10825259714222 bayes_pls_golite062009
erythropoietin receptor binding 0.77580300541347 bayes_pls_golite062009
interleukin-3 receptor binding 0.264629367313661 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
interleukin-12 receptor binding 0.218984052557791 bayes_pls_golite062009
transcription regulator activity 0.010318258615897 bayes_pls_golite062009

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