YRC Public Data Repository - Protein Structure Prediction

Protein:	HYPF_ECOLI
Organism:	Escherichia coli
Length:	750 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HYPF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|17130039, gi\|... - gi\|17228189\|ref\|NP_484737.1\| hydrogenase maturation protein [Nostoc sp. PCC 7120], gi\|17130039\|dbj\|B... gi\|25324741 - pir\|\|AD1893 hydrogenase maturation protein [imported] - Nostoc sp. (strain PCC 7120)	719.0	[0..6]	[744..1]
gi\|50120190, gi\|... - gi\|50120190\|ref\|YP_049357.1\| hydrogenase maturation protein [Pectobacterium atrosepticum SCRI1043], ...	715.0	[0..8]	[744..14]
gi\|82778081, gi\|... - gi\|82778081\|ref\|YP_404430.1\| transcriptional regulatory protein [Shigella dysenteriae Sd197], gi\|812...	715.0	[0..1]	[750..1]
gi\|56383719, gi\|... - gi\|56480168\|ref\|NP_708519.2\| transcriptional regulatory protein [Shigella flexneri 2a str. 301], gi\|... gi\|110616211, gi... - gi\|110806663\|ref\|YP_690183.1\| transcriptional regulatory protein [Shigella flexneri 5 str. 8401], gi... gi\|30064071, gi\|... - gi\|30064071\|ref\|NP_838242.1\| transcriptional regulatory protein [Shigella flexneri 2a str. 2457T], g...	712.0	[0..1]	[750..1]
gi\|208735203, gi... - gi\|208813926\|ref\|ZP_03255255.1\| carbamoyltransferase HypF [Escherichia coli O157:H7 str. EC4045], gi... gi\|195938461 - gi\|195938461\|ref\|ZP_03083843.1\| transcriptional regulatory protein [Escherichia coli O157:H7 str. EC... gi\|168749964, gi... - gi\|188015770\|gb\|EDU53892.1\| carbamoyltransferase HypF [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|168800208, gi... - gi\|189377506\|gb\|EDU95922.1\| carbamoyltransferase HypF [Escherichia coli O157:H7 str. EC508], gi\|1688... gi\|168774757, gi... - gi\|187769621\|gb\|EDU33465.1\| carbamoyltransferase HypF [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|254594052, gi... - gi\|254794652\|ref\|YP_003079489.1\| carbamoyl phosphate phosphatase and maturation protein for [NiFe] h... gi\|209761978, gi... - pir\|\|H91074 transcription regulatory protein [imported] - Escherichia coli (strain O157:H7, substrai... gi\|13363039, gi\|... - gi\|15832822\|ref\|NP_311595.1\| transcriptional regulatory protein [Escherichia coli O157:H7 str. Sakai... gi\|13363039, gi\|... - gi\|15832822\|ref\|NP_311595.1\| transcriptional regulatory protein [Escherichia coli O157:H7], gi\|13363...	710.0	[0..1]	[750..1]
gi\|25324735 - pir\|\|G85919 transcription regulatory protein [imported] - Escherichia coli (strain O157:H7, substrai... gi\|15803229, gi\|... - gi\|15803229\|ref\|NP_289261.1\| transcriptional regulatory protein [Escherichia coli O157:H7 EDL933], g...	710.0	[0..1]	[750..1]
gi\|218696303, gi... - gi\|218696303\|ref\|YP_002403970.1\| carbamoyl phosphate phosphatase and maturation protein for [NiFe] h... gi\|75235695 - gi\|75235695\|ref\|ZP_00719869.1\| COG0068: Hydrogenase maturation factor [Escherichia coli E110019] gi\|75230082 - gi\|75230082\|ref\|ZP_00716592.1\| COG0068: Hydrogenase maturation factor [Escherichia coli B7A]	709.0	[0..1]	[750..1]
gi\|75910798, gi\|... - gi\|75910798\|ref\|YP_325094.1\| hydrogenase maturation protein HypF [Anabaena variabilis ATCC 29413], g...	707.0	[0..6]	[744..1]
gi\|75256912 - gi\|75256912\|ref\|ZP_00728488.1\| COG0068: Hydrogenase maturation factor [Escherichia coli E22] gi\|218362022, gi... - gi\|218555254\|ref\|YP_002388167.1\| carbamoyl phosphate phosphatase and maturation protein for [NiFe] h...	707.0	[0..1]	[750..1]
gi\|882605 - gi\|882605\|gb\|AAA69222.1\| CG Site No. 18232; alternate gene name hypF gi\|882605\|gb\|AAA... - CG Site No. 18232; alternate gene name hypF	707.0	[0..1]	[750..1]

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Predicted Domain #1

Region A:
Residues: [1-92]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKNTSCGVQ LRIRGKVQGV GFRPFVWQLA QQLNLHGDVC NDGDGVEVRL REDPETFLVQ  60
   61 LYQHCPPLAR IDSVEREPFI WSQLPTEFTI RQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.69897
Match:	1gxtA
Description:	Hydrogenase maturation protein HypF N-terminal domain (HypF-ACP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.52035558898316	bayes_pls_golite062009
hydrolase activity	0.582382488349249	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [93-181]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STGGTMNTQI VPDAATCPAC LAEMNTPGER RYRYPFINCT HCGPRFTIIR AMPYDRPFTV  60
   61 MAAFPLCPAC DKEYRDPLDR RFHAQPVAC

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.36
Match:	1wjpA
Description:	Solution structure of zf-C2H2 domains from human Zinc finger protein 295
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	1.12023123749051	bayes_pls_golite062009
binding	1.0649612944442	bayes_pls_golite062009
DNA binding	0.866878081129177	bayes_pls_golite062009
transcription regulator activity	0.745130007888569	bayes_pls_golite062009
catalytic activity	0.633447548613749	bayes_pls_golite062009
protein binding	0.217824216711205	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [182-443]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PECGPHLEWV SHGEHAEQEA ALQAAIAQLK MGKIVAIKGI GGFHLACDAR NSNAVATLRA  60
   61 RKHRPAKPLA VMLPVADGLP DAARQLLTTP AAPIVLVDKK YVPELCDDIA PDLNEVGVML 120
  121 PANPLQHLLL QELQCPLVMT SGNLSGKPPA ISNEQALADL QGIADGFLIH NRDIVQRMDD 180
  181 SVVRESGEML RRSRGYVPDA LALPPGFKNV PPVLCLGADL KNTFCLVRGE QAVLSQHLGD 240
  241 LSDDGIQMQW REALRLMQNI YD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.30103
Match:	1kk9A
Description:	Hypothetical protein YciO
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.71407687320205	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [444-750]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTPQYVVHDA HPGYVSSQWA REMNLPTQTV LHHHAHAAAC LAEHQWPLDG GDVIALTLDG  60
   61 IGMGENGALW GGECLRVNYR ECEHLGGLPA VALPGGDLAA KQPWRNLLAQ CLRFVPEWQN 120
  121 YSETASVQQQ NWSVLARAIE RGINAPLASS CGRFFDAVAA ALGCAPATLS YEGEAACALE 180
  181 ALAASCHGVT HPVTMPRVDN QLDLATFWQQ WLNWQAPVNQ RAWAFHDALA QGFAALMREQ 240
  241 ATMRGITTLV FSGGVIHNRL LRARLAHYLA DFTLLFPQSL PAGDGGLSLG QGVIAAARWL 300
  301 AGEVQNG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.154902
Match:	2ivnA
Description:	No description for 2ivnA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: