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View Structure Prediction Details

Protein: HMOX1
Organism: Homo sapiens
Length: 288 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMOX1.

Description E-value Query
Range		 Subject
Range
gi|16306631 - gi|16306631|gb|AAH01491.1| Heme oxygenase (decycling) 1 [Homo sapiens]
gi|123997669, gi... - gi|123997669|gb|ABM86436.1| heme oxygenase (decycling) 1 [synthetic construct], gi|123982990|gb|ABM8...
 0.0 [1..288] [1..288]
gi|60826835 - gi|60826835|gb|AAX36773.1| heme oxygenase 1 [synthetic construct]
 0.0 [1..288] [1..288]
gi|55731206 - gi|55731206|emb|CAH92317.1| hypothetical protein [Pongo abelii]
HMOX1_PONAB - Heme oxygenase 1 OS=Pongo abelii GN=HMOX1 PE=2 SV=1
 0.0 [1..288] [1..288]
HMOX1_MOUSE - Heme oxygenase 1 OS=Mus musculus GN=Hmox1 PE=1 SV=1
 0.0 [1..288] [1..289]
gi|109094007 - gi|109094007|ref|XP_001113241.1| PREDICTED: heme oxygenase (decyclizing) 1 [Macaca mulatta]
 1.0E-98 [1..288] [36..323]
HMOX1_PIG - Heme oxygenase 1 OS=Sus scrofa GN=HMOX1 PE=2 SV=1
gi|481051 - pir||S37687 heme oxygenase (decyclizing) (EC 1.14.99.3) - pig
 2.0E-97 [1..288] [1..288]
gi|73969864 - gi|73969864|ref|XP_853145.1| PREDICTED: similar to Heme oxygenase 1 (HO-1) [Canis familiaris]
 2.0E-96 [9..288] [59..338]
HMOX2_RAT - Heme oxygenase 2 OS=Rattus norvegicus GN=Hmox2 PE=1 SV=1
 7.0E-95 [2..288] [21..315]

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Predicted Domain #1
Region A:
Residues: [1-288] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA  60
   61 LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE 120
  121 VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ 180
  181 LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA 240
  241 SNKVQDSAPV ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.0
Match: 1n3uA
Description: Heme oxygenase-1 (HO-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
heme oxygenase (decyclizing) activity 6.35661824588808 bayes_pls_golite062009
transcription regulator activity 2.47421036599568 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2.32609615281187 bayes_pls_golite062009
phospholipase D activity 2.1038500403394 bayes_pls_golite062009
transcription activator activity 1.8437051905231 bayes_pls_golite062009
binding 1.80342520508546 bayes_pls_golite062009
protein binding 1.48866689171126 bayes_pls_golite062009
signal transducer activity 1.35629718564798 bayes_pls_golite062009
molecular transducer activity 1.35629718564798 bayes_pls_golite062009
phospholipase activity 0.531983170241739 bayes_pls_golite062009
catalytic activity 0.476060647762462 bayes_pls_golite062009
enzyme binding 0.058922845254932 bayes_pls_golite062009
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