YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS5_THEMA
Organism:	Thermotoga maritima
Length:	201 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS5_THEMA.

Description	E-value	Query Range	Subject Range
HIS5_MOOTA - Imidazole glycerol phosphate synthase subunit HisH OS=Moorella thermoacetica (strain ATCC 39073) GN=...	162.0	[0..1]	[199..1]
gi\|2983181, gi\|1... - gi\|2983181\|gb\|AAC06781.1\| anthranilate synthase component II [Aquifex aeolicus VF5], gi\|15606008\|ref... gi\|7436747 - pir\|\|E70349 anthranilate synthase component II - Aquifex aeolicus	161.0	[0..1]	[201..1]
gi\|196252975, gi... - gi\|196252975\|ref\|ZP_03151620.1\| imidazole glycerol phosphate synthase, glutamine amidotransferase su... gi\|125715592, gi... - gi\|67876072\|ref\|ZP_00505104.1\| Imidazole glycerol phosphate synthase, glutamine amidotransferase sub...	160.0	[0..3]	[197..2]
gi\|88925113, gi\|... - gi\|88945240\|ref\|ZP_01148454.1\| Imidazole glycerol phosphate synthase, glutamine amidotransferase sub...	160.0	[0..3]	[199..2]
gi\|34398203 - gi\|34398203\|gb\|AAQ67191.1\| CAD [Platypalpus sp. NCSU-99071984]	158.0	[0..2]	[200..133]
gi\|34398173 - gi\|34398173\|gb\|AAQ67176.1\| CAD [Epalpus signifer]	158.0	[0..2]	[200..133]
gi\|110601328, gi... - gi\|222053794\|ref\|YP_002536156.1\| imidazole glycerol phosphate synthase, glutamine amidotransferase s...	156.0	[0..3]	[193..2]
gi\|34398201 - gi\|34398201\|gb\|AAQ67190.1\| CAD [Phora sp. JS299]	156.0	[0..2]	[200..133]
HIS5_DESHD - Imidazole glycerol phosphate synthase subunit HisH OS=Desulfitobacterium hafniense (strain DCB-2 / D...	155.0	[0..3]	[199..2]
gi\|34398205 - gi\|34398205\|gb\|AAQ67192.1\| CAD [Rhamphomyia sp. NCSU-97010438]	155.0	[0..2]	[200..133]

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Predicted Domain #1

Region A:
Residues: [1-201]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIGIISVGP GNIMNLYRGV KRASENFEDV SIELVESPRN DLYDLLFIPG VGHFGEGMRR  60
   61 LRENDLIDFV RKHVEDERYV VGVCLGMQLL FEESEEAPGV KGLSLIEGNV VKLRSRRLPH 120
  121 MGWNEVIFKD TFPNGYYYFV HTYRAVCEEE HVLGTTEYDG EIFPSAVRKG RILGFQFHPE 180
  181 KSSKIGRKLL EKVIECSLSR R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.69897
Match:	1gpwB
Description:	GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate synthase activity	2.6536917506322	bayes_pls_golite062009
catalytic activity	1.67435536171189	bayes_pls_golite062009
ligase activity	1.25010133890527	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	1.13665224189802	bayes_pls_golite062009
anthranilate synthase activity	0.21391494060026	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	0.113939560975652	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.100283432019111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: