YRC Public Data Repository - Protein Structure Prediction

Protein:	HCAT_ECOLI
Organism:	Escherichia coli
Length:	379 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HCAT_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110827356, gi... - gi\|111615223\|ref\|ZP_01402289.1\| Sugar phosphate permease-like [Verminephrobacter eiseniae EF01-2], g...	162.0	[0..3]	[376..301]
gi\|78495751, gi\|... - gi\|78495751\|ref\|ZP_00847969.1\| Major facilitator superfamily MFS_1 [Rhodopseudomonas palustris BisB1...	153.0	[0..3]	[376..450]
gi\|218202668 - gi\|218202668\|gb\|EEC85095.1\| hypothetical protein OsI_32467 [Oryza sativa Indica Group] PHT44_ORYSJ - Probable anion transporter 4, chloroplastic OS=Oryza sativa subsp. japonica GN=PHT4;4 PE=2 SV=1	151.0	[0..2]	[373..181]
gi\|68389434 - gi\|68389434\|ref\|XP_691920.1\| PREDICTED: similar to solute carrier family 17 (sodium-dependent inorga...	141.0	[0..1]	[378..140]
gi\|85110133 - gi\|85110133\|ref\|XP_963279.1\| hypothetical protein [Neurospora crassa OR74A] gi\|28924953, gi\|... - gi\|32417950\|ref\|XP_329453.1\| hypothetical protein [Neurospora crassa], gi\|28924953\|gb\|EAA34043.1\| hy...	140.0	[0..6]	[379..385]
gi\|60467752, gi\|... - gi\|60467752\|gb\|EAL65769.1\| hypothetical protein DDB0191430 [Dictyostelium discoideum], gi\|29500764\|g... gi\|60467752, gi\|... - gi\|66810832\|ref\|XP_639123.1\| major facilitator superfamily transporter [Dictyostelium discoideum AX4...	136.0	[0..5]	[374..603]
gi\|17064976, gi\|... - gi\|21387197\|gb\|AAM48002.1\| putative Na+-dependent inorganic phosphate cotransporter [Arabidopsis tha...	135.0	[0..2]	[373..102]
gi\|134052234, gi... - gi\|88947352\|ref\|ZP_01150349.1\| similar to multidrug resistance protein [Desulfotomaculum reducens MI...	133.0	[0..2]	[377..15]

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Predicted Domain #1

Region A:
Residues: [1-379]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLQSTRWLA LGYFTYFFSY GIFLPFWSVW LKGIGLTPET IGLLLGAGLV ARFLGSLLIA  60
   61 PRVSDPSRLI SALRVLALLT LLFAVAFWAG AHVAWLMLVM IGFNLFFSPL VPLTDALANT 120
  121 WQKQFPLDYG KVRLWGSVAF VIGSALTGKL VTMFDYRVIL ALLTLGVASM LLGFLIRPTI 180
  181 QPQGASRQQE STGWSAWLAL VRQNWRFLAC VCLLQGAHAA YYGFSAIYWQ AAGYSASAVG 240
  241 YLWSLGVVAE VIIFALSNKL FRRCSARDML LISAICGVVR WGIMGATTAL PWLIVVQILH 300
  301 CGTFTVCHLA AMRYIAARQG SEVIRLQAVY SAVAMGGSIA IMTVFAGFLY QYLGHGVFWV 360
  361 MALVALPAMF LRPKVVPSC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.69897
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	2.57064006681892	bayes_pls_golite062009
transmembrane transporter activity	2.01570582004142	bayes_pls_golite062009
substrate-specific transporter activity	1.88962978954753	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.790861390207	bayes_pls_golite062009
binding	0.543811221622693	bayes_pls_golite062009
ion transmembrane transporter activity	0.429573484810655	bayes_pls_golite062009
active transmembrane transporter activity	0.128049316281043	bayes_pls_golite062009
polyol transmembrane transporter activity	0.0962919419162489	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.0962919419162489	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.0654086519983542	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: