YRC Public Data Repository - Protein Structure Prediction

Protein:	GSA_ECOLI
Organism:	Escherichia coli
Length:	426 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GSA_ECOLI.

Description	E-value	Query Range	Subject Range
GSA_HAES1 - Glutamate-1-semialdehyde 2,1-aminomutase OS=Haemophilus somnus (strain 129Pt) GN=hemL PE=3 SV=1	437.0	[0..1]	[426..1]
GSA_HISS2 - Glutamate-1-semialdehyde 2,1-aminomutase OS=Histophilus somni (strain 2336) GN=hemL PE=3 SV=1	434.0	[0..1]	[426..1]
GSA_MANSM - Glutamate-1-semialdehyde 2,1-aminomutase OS=Mannheimia succiniciproducens (strain MBEL55E) GN=hemL P...	426.0	[0..1]	[416..1]
gi\|32033392 - gi\|32033392\|ref\|ZP_00133736.1\| COG0001: Glutamate-1-semialdehyde aminotransferase [Actinobacillus pl... GSA_ACTP2 - Glutamate-1-semialdehyde 2,1-aminomutase OS=Actinobacillus pleuropneumoniae serotype 5b (strain L20)...	426.0	[0..1]	[426..1]
GSA_ACTSZ - Glutamate-1-semialdehyde 2,1-aminomutase OS=Actinobacillus succinogenes (strain ATCC 55618 / 130Z) G...	423.0	[0..1]	[426..1]
GSA_PASMU - Glutamate-1-semialdehyde 2,1-aminomutase OS=Pasteurella multocida (strain Pm70) GN=hemL PE=3 SV=1 GSA_PASMU - Glutamate-1-semialdehyde 2,1-aminomutase OS=Pasteurella multocida GN=hemL PE=3 SV=1	423.0	[0..1]	[426..1]
gi\|89095113, gi\|... - gi\|89095113\|ref\|ZP_01168039.1\| glutamate-1-semialdehyde 2,1-aminomutase [Oceanospirillum sp. MED92],...	418.0	[0..1]	[426..1]
gi\|94425750, gi\|... - gi\|94502113\|ref\|ZP_01308615.1\| glutamate-1-semialdehyde-2,1-aminomutase [Oceanobacter sp. RED65], gi...	417.0	[0..2]	[426..4]
gi\|75854599, gi\|... - gi\|75854599\|ref\|ZP_00762284.1\| COG0001: Glutamate-1-semialdehyde aminotransferase [Vibrio sp. Ex25],...	417.0	[0..1]	[426..15]
GSA_IDILO - Glutamate-1-semialdehyde 2,1-aminomutase OS=Idiomarina loihiensis GN=hemL PE=3 SV=1 GSA_IDILO - Glutamate-1-semialdehyde 2,1-aminomutase OS=Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 /...	417.0	[0..1]	[426..1]

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Predicted Domain #1

Region A:
Residues: [1-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKSENLYSA ARELIPGGVN SPVRAFTGVG GTPLFIEKAD GAYLYDVDGK AYIDYVGSWG  60
   61 PMVLGHNHPA IRNAVIEAAE RGLSFGAPTE MEVKMAQLVT ELVPTMDMVR MVNSGTEATM 120
  121 SAIRLARGFT GRDKIIKFEG CYHGHADCLL VKAGSGALTL GQPNSPGVPA DFAKYTLTCT 180
  181 YNDLASVRAA FEQYPQEIAC IIVEPVAGNM NCVPPLPEFL PGLRALCDEF GALLIIDEVM 240
  241 TGFRVALAGA QDYYGVVPDL TCLGKIIGGG MPVGAFGGRR DVMDALAPTG PVYQAGTLSG 300
  301 NPIAMAAGFA CLNEVAQPGV HETLDELTTR LAEGLLEAAE EAGIPLVVNH VGGMFGIFFT 360
  361 DAESVTCYQD VMACDVERFK RFFHMMLDEG VYLAPSAFEA GFMSVAHSME DINNTIDAAR 420
  421 RVFAKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	2gsaA
Description:	Glutamate-1-semialdehyde aminomutase (aminotransferase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.29878871754893	bayes_pls_golite062009
5-aminolevulinate synthase activity	1.85905571238884	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	1.63055151623667	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	1.63055151623667	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	0.947097582254635	bayes_pls_golite062009
transferase activity	0.737426388870721	bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups	0.659071155545801	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	0.619695949258279	bayes_pls_golite062009
N-succinyltransferase activity	0.52897097514616	bayes_pls_golite062009
ornithine-oxo-acid transaminase activity	0.311107335626334	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: