YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|208968221, gi...
Organism:	synthetic construct
Length:	395 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|208968221, gi....

Description	E-value	Query Range	Subject Range
TF2H2_RAT - General transcription factor IIH subunit 2 OS=Rattus norvegicus GN=Gtf2h2 PE=1 SV=1	0.0	[1..395]	[1..396]
TF2H2_BOVIN - General transcription factor IIH subunit 2 OS=Bos taurus GN=GTF2H2 PE=2 SV=1	0.0	[1..395]	[1..395]
sp\|Q13888\|TF2H2_... - General transcription factor IIH subunit 2 OS=Homo sapiens GN=GTF2H2 PE=1 SV=1 VAR_011664, General t... gi\|109077533, gi... - gi\|109077533\|ref\|XP_001095784.1\| PREDICTED: general transcription factor IIH, polypeptide 2, 44kD su...	0.0	[1..395]	[1..395]
GTF2H2D, GTF2H2C - general transcription factor IIH, polypeptide 2D, general transcription factor IIH, polypeptide 2C	0.0	[1..395]	[1..395]
gi\|114599833, gi... - gi\|114599833\|ref\|XP_001158128.1\| PREDICTED: general transcription factor IIH, polypeptide 2, 44kD su...	0.0	[1..395]	[1..395]
gi\|31981225, gi\|... - gi\|31981225\|ref\|NP_071294.2\| general transcription factor II H, polypeptide 2 [Mus musculus], gi\|314...	0.0	[1..395]	[1..396]
gi\|73949709 - gi\|73949709\|ref\|XP_535266.2\| PREDICTED: similar to TFIIH basal transcription factor complex p44 subu...	0.0	[1..395]	[1..395]

Back

Predicted Domain #1

Region A:
Residues: [1-254]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH  60
   61 LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL 120
  121 SGNPRKHITS LKKAVDMTCH GEPSLYNSLS IAMQTLKHMP GHTSREVLII FSSLTTCDPS 180
  181 NIYDLIKTLK AAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHVSPPP 240
  241 ASSSSECSLI RMGF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.69897
Match:	2ok5A
Description:	No description for 2ok5A was found.

Predicted functions:

Term	Confidence	Notes
binding	2.75824485094584	bayes_pls_golite062009
nucleic acid binding	2.08531850924748	bayes_pls_golite062009
DNA binding	1.91667917801679	bayes_pls_golite062009
protein binding	1.53311876872122	bayes_pls_golite062009
protein complex binding	0.68878168136573	bayes_pls_golite062009
hydrolase activity	0.564965244474085	bayes_pls_golite062009
structure-specific DNA binding	0.450760554291027	bayes_pls_golite062009
protein dimerization activity	0.4223194470523	bayes_pls_golite062009
protein heterodimerization activity	0.32921284315242	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [255-307]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQHTIASLSD QDAKPSFSMA HLDGNTEPGL TLGGYFCPQC RAKYCELPVE CKI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [308-395]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGLTLVSAPH LARSYHHLFP LDAFQEIPLE EYNGERFCYG CQGELKDQHV YVCAVCQNVF  60
   61 CVDCDVFVHD SLHCCPGCIH KIPAPSGV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.39794
Match:	1z60A
Description:	Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: