YRC Public Data Repository - Protein Structure Prediction

Protein:	GALE_ECOLI
Organism:	Escherichia coli
Length:	338 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GALE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|221325375 - gi\|221325375\|ref\|ZP_03606669.1\| UDP-glucose 4-epimerase [Bacillus subtilis subsp. subtilis str. SMY] gi\|221321091 - gi\|221321091\|ref\|ZP_03602385.1\| UDP-glucose 4-epimerase [Bacillus subtilis subsp. subtilis str. JH64... gi\|221316179 - gi\|221316179\|ref\|ZP_03597984.1\| UDP-glucose 4-epimerase [Bacillus subtilis subsp. subtilis str. NCIB... GALE_BACSU - UDP-glucose 4-epimerase OS=Bacillus subtilis (strain 168) GN=galE PE=3 SV=1 GALE_BACSU - UDP-glucose 4-epimerase OS=Bacillus subtilis GN=galE PE=3 SV=1	372.0	[0..1]	[337..1]
gi\|37528640, gi\|... - gi\|37528640\|ref\|NP_931985.1\| UDP-glucose 4-epimerase (galactowaldenase) (UDP-galactose 4-epimerase) ...	367.0	[0..1]	[337..1]
gi\|77960609, gi\|... - gi\|77960609\|ref\|ZP_00824473.1\| COG1087: UDP-glucose 4-epimerase [Yersinia mollaretii ATCC 43969], gi...	366.0	[0..1]	[338..1]
gi\|218553279, gi... - gi\|218553279\|ref\|YP_002386192.1\| UDP-galactose-4-epimerase [Escherichia coli IAI1], gi\|218360047\|emb... gi\|218426107, gi... - gi\|218688543\|ref\|YP_002396755.1\| UDP-galactose-4-epimerase [Escherichia coli ED1a], gi\|218426107\|emb... gi\|218369110, gi... - gi\|218699124\|ref\|YP_002406753.1\| UDP-galactose-4-epimerase [Escherichia coli IAI39], gi\|218369110\|em... gi\|218431176, gi... - gi\|218704079\|ref\|YP_002411598.1\| UDP-galactose-4-epimerase [Escherichia coli UMN026], gi\|218431176\|e... gi\|74311277, gi\|... - gi\|74311277\|ref\|YP_309696.1\| UDP-galactose-4-epimerase [Shigella sonnei Ss046], gi\|73854754\|gb\|AAZ87... gi\|189366419, gi... - gi\|189366419\|gb\|EDU84835.1\| UDP-glucose 4-epimerase [Escherichia coli O157:H7 str. EC4501], gi\|16876... gi\|189373157, gi... - gi\|189373157\|gb\|EDU91573.1\| UDP-glucose 4-epimerase [Escherichia coli O157:H7 str. EC869], gi\|168786... gi\|170683375, gi... - gi\|170683375\|ref\|YP_001742862.1\| UDP-glucose 4-epimerase [Escherichia coli SMS-3-5], gi\|170521093\|gb... gi\|217324140, gi... - gi\|217324140\|ref\|ZP_03440224.1\| UDP-glucose 4-epimerase [Escherichia coli O157:H7 str. TW14588], gi\|... gi\|218357215, gi... - gi\|218549674\|ref\|YP_002383465.1\| UDP-galactose-4-epimerase [Escherichia fergusonii ATCC 35469], gi\|2... gi\|194416734, gi... - gi\|83568961\|ref\|ZP_00920426.1\| COG1087: UDP-glucose 4-epimerase [Shigella dysenteriae 1012], gi\|1944... gi\|75189773, gi\|... - gi\|75189773\|ref\|ZP_00703040.1\| COG1087: UDP-glucose 4-epimerase [Escherichia coli E24377A], gi\|15715... gi\|13360246 - gi\|13360246\|dbj\|BAB34210.1\| UDP-galactose-4-epimerase [Escherichia coli O157:H7 str. Sakai] gi\|13360246 - gi\|13360246\|dbj\|BAB34210.1\| UDP-galactose-4-epimerase [Escherichia coli O157:H7] gi\|110342552, gi... - gi\|110640960\|ref\|YP_668688.1\| UDP-galactose-4-epimerase [Escherichia coli 536], gi\|110342552\|gb\|ABG6... gi\|209776284, gi... - pir\|\|D85578 UDP-galactose-4-epimerase [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15800468, gi\|... - gi\|15800468\|ref\|NP_286480.1\| UDP-galactose-4-epimerase [Escherichia coli O157:H7 EDL933], gi\|1251368... gi\|75237095, gi\|... - gi\|75237095\|ref\|ZP_00721149.1\| COG1087: UDP-glucose 4-epimerase [Escherichia coli F11], gi\|191174180... gi\|26107124, gi\|... - gi\|26246725\|ref\|NP_752765.1\| UDP-galactose-4-epimerase [Escherichia coli CFT073], gi\|26107124\|gb\|AAN... gi\|193065580, gi... - gi\|75256343\|ref\|ZP_00728013.1\| COG1087: UDP-glucose 4-epimerase [Escherichia coli E22], gi\|193065580... gi\|194412259, gi... - gi\|75209072\|ref\|ZP_00709330.1\| COG1087: UDP-glucose 4-epimerase [Escherichia coli B171], gi\|19442970... gi\|192957096, gi... - gi\|75235776\|ref\|ZP_00719931.1\| COG1087: UDP-glucose 4-epimerase [Escherichia coli E110019], gi\|19306...	365.0	[0..1]	[338..1]
gi\|38703888 - gi\|38703888\|ref\|NP_308814.2\| UDP-galactose-4-epimerase [Escherichia coli O157:H7] gi\|38703888 - gi\|38703888\|ref\|NP_308814.2\| UDP-galactose-4-epimerase [Escherichia coli O157:H7 str. Sakai]	365.0	[0..1]	[338..5]
gi\|187731338, gi... - gi\|75175245\|ref\|ZP_00695555.1\| COG1087: UDP-glucose 4-epimerase [Shigella boydii BS512], gi\|18773133... gi\|209776278 - gi\|209776278\|gb\|ACI86451.1\| UDP-galactose-4-epimerase [Escherichia coli]	365.0	[0..1]	[338..1]
gi\|91071361, gi\|... - gi\|91209787\|ref\|YP_539773.1\| UDP-galactose-4-epimerase [Escherichia coli UTI89], gi\|91071361\|gb\|ABE0... gi\|218364434, gi... - gi\|218557665\|ref\|YP_002390578.1\| UDP-galactose-4-epimerase [Escherichia coli S88], gi\|218364434\|emb\|... gi\|226898495, gi... - gi\|237707285\|ref\|ZP_04537766.1\| UDP-galactose-4-epimerase [Escherichia sp. 3_2_53FAA], gi\|226898495\|...	365.0	[0..1]	[338..1]
gi\|238723050, gi... - gi\|77973944\|ref\|ZP_00829488.1\| COG1087: UDP-glucose 4-epimerase [Yersinia frederiksenii ATCC 33641],...	365.0	[0..1]	[338..1]
gi\|56383239, gi\|... - gi\|56479688\|ref\|NP_706482.2\| UDP-galactose-4-epimerase [Shigella flexneri 2a str. 301], gi\|56383239\|... gi\|30062085, gi\|... - gi\|30062085\|ref\|NP_836256.1\| UDP-galactose-4-epimerase [Shigella flexneri 2a str. 2457T], gi\|3004032...	365.0	[0..1]	[338..1]
gi\|115512067, gi... - gi\|117622943\|ref\|YP_851856.1\| UDP-galactose-4-epimerase [Escherichia coli APEC O1], gi\|115512067\|gb\|...	365.0	[0..1]	[338..15]

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Predicted Domain #1

Region A:
Residues: [1-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVLVTGGSG YIGSHTCVQL LQNGHDVIIL DNLCNSKRSV LPVIERLGGK HPTFVEGDIR  60
   61 NEALMTEILH DHAIDTVIHF AGLKAVGESV QKPLEYYDNN VNGTLRLISA MRAANVKNFI 120
  121 FSSSATVYGD QPKIPYVESF PTGTPQSPYG KSKLMVEQIL TDLQKAQPDW SIALLRYFNP 180
  181 VGAHPSGDMG EDPQGIPNNL MPYIAQVAVG RRDSLAIFGN DYPTEDGTGV RDYIHVMDLA 240
  241 DGHVVAMEKL ANKPGVHIYN LGAGVGNSVL DVVNAFSKAC GKPVNYHFAP RREGDLPAYW 300
  301 ADASKADREL NWRVTRTLDE MAQDTWHWQS RHPQGYPD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	101.0
Match:	1udcA
Description:	STRUCTURE OF UDP-GALACTOSE-4-EPIMERASE COMPLEXED WITH UDP-MANNOSE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
UDP-glucose 4-epimerase activity	2.13934644118967	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
nucleic acid binding	0.868888700854563	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
DNA binding	0.790382977752475	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
transcription regulator activity	0.613310508772122	bayes_pls_golite062009
transcription factor activity	0.11102650759187	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: