YRC Public Data Repository - Protein Structure Prediction

Protein:	FUCI_ECOLI
Organism:	Escherichia coli
Length:	591 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUCI_ECOLI.

Description	E-value	Query Range	Subject Range
FUCI_ECOLC - L-fucose isomerase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=fucI PE=3 SV=1 FUCI_ECOHS - L-fucose isomerase OS=Escherichia coli O9:H4 (strain HS) GN=fucI PE=3 SV=1 gi\|124528767, gi... - gi\|124528767\|ref\|ZP_01699991.1\| L-fucose isomerase [Escherichia coli B], gi\|124500295\|gb\|EAY47770.1\|...	872.0	[0..1]	[591..1]
gi\|193065095, gi... - gi\|75256859\|ref\|ZP_00728453.1\| COG2407: L-fucose isomerase and related proteins [Escherichia coli E2... gi\|194415603, gi... - gi\|75212578\|ref\|ZP_00712602.1\| COG2407: L-fucose isomerase and related proteins [Escherichia coli B1... FUCI_ECO55 - L-fucose isomerase OS=Escherichia coli (strain 55989 / EAEC) GN=fucI PE=3 SV=1	871.0	[0..1]	[591..1]
gi\|193071122, gi... - gi\|75233972\|ref\|ZP_00718421.1\| COG2407: L-fucose isomerase and related proteins [Escherichia coli E1...	870.0	[0..1]	[591..1]
FUCI_ECOL6 - L-fucose isomerase OS=Escherichia coli O6 GN=fucI PE=3 SV=1 gi\|227834613, gi... - gi\|227888344\|ref\|ZP_04006149.1\| L-fucose isomerase [Escherichia coli 83972], gi\|227834613\|gb\|EEJ4507... FUCI_ECOL6 - L-fucose isomerase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=fucI PE=3 SV=1	870.0	[0..1]	[591..1]
FUCI_ECOL5 - L-fucose isomerase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=fucI PE=3 SV=1 gi\|75241808, gi\|... - gi\|75241808\|ref\|ZP_00725627.1\| COG2407: L-fucose isomerase and related proteins [Escherichia coli F1...	869.0	[0..1]	[591..1]
FUCI_ECO24 - L-fucose isomerase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=fucI PE=3 SV=1	869.0	[0..1]	[591..1]
gi\|254594143, gi... - gi\|254794743\|ref\|YP_003079580.1\| L-fucose isomerase [Escherichia coli O157:H7 str. TW14359], gi\|2545... gi\|13363134, gi\|... - gi\|15832916\|ref\|NP_311689.1\| L-fucose isomerase [Escherichia coli O157:H7 str. Sakai], gi\|13363134\|d... FUCI_ECO5E - L-fucose isomerase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=fucI PE=3 SV=1 gi\|208818268, gi... - gi\|208818268\|ref\|ZP_03258588.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4042], gi\|208738... gi\|208813591, gi... - gi\|208813591\|ref\|ZP_03254920.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4045], gi\|208734... gi\|187767209, gi... - gi\|187767209\|gb\|EDU31053.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4196], gi\|168777572\|... gi\|189363881, gi... - gi\|189363881\|gb\|EDU82300.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4486], gi\|168766775\|... gi\|168758187, gi... - gi\|189354946\|gb\|EDU73365.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4401], gi\|168758187\|... gi\|168751019, gi... - gi\|188014876\|gb\|EDU52998.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4113], gi\|168751019\|... gi\|208806197, gi... - gi\|208806197\|ref\|ZP_03248534.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4206], gi\|208725... gi\|195936406 - gi\|195936406\|ref\|ZP_03081788.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4024] gi\|189376218, gi... - gi\|189376218\|gb\|EDU94634.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC508], gi\|168801666\|r... gi\|189003338, gi... - gi\|189003338\|gb\|EDU72324.1\| L-fucose isomerase [Escherichia coli O157:H7 str. EC4076], gi\|168778796\|... gi\|25292877, gi\|... - pir\|\|H85931 L-fucose isomerase [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pi... gi\|15803324, gi\|... - gi\|15803324\|ref\|NP_289357.1\| L-fucose isomerase [Escherichia coli O157:H7 EDL933], gi\|12517281\|gb\|AA... FUCI_ECO57 - L-fucose isomerase OS=Escherichia coli O157:H7 GN=fucI PE=3 SV=1	869.0	[0..1]	[591..1]
FUCI_ECOUT - L-fucose isomerase OS=Escherichia coli (strain UTI89 / UPEC) GN=fucI PE=3 SV=1 FUCI_ECOK1 - L-fucose isomerase OS=Escherichia coli O1:K1 / APEC GN=fucI PE=3 SV=1 FUCI_ECO45 - L-fucose isomerase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=fucI PE=3 SV=1 gi\|237706566, gi... - gi\|237706566\|ref\|ZP_04537047.1\| L-fucose isomerase [Escherichia sp. 3_2_53FAA], gi\|226899606\|gb\|EEH8... FUCI_ECO81 - L-fucose isomerase OS=Escherichia coli O81 (strain ED1a) GN=fucI PE=3 SV=1	868.0	[0..1]	[591..1]
gi\|194439654, gi... - gi\|83584938\|ref\|ZP_00923594.1\| COG2407: L-fucose isomerase and related proteins [Escherichia coli 10... gi\|253974634, gi... - gi\|254162733\|ref\|YP_003045841.1\| L-fucose isomerase [Escherichia coli B str. REL606], gi\|253974634\|g... gi\|253323385, gi... - gi\|254289492\|ref\|YP_003055240.1\| L-fucose isomerase [Escherichia coli BL21(DE3)], gi\|253978799\|gb\|AC...	865.0	[0..1]	[591..1]
gi\|238729483, gi... - gi\|77979713\|ref\|ZP_00835130.1\| COG2407: L-fucose isomerase and related proteins [Yersinia intermedia...	863.0	[0..2]	[591..3]

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Predicted Domain #1

Region A:
Residues: [1-591]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKISLPKIG IRPVIDGRRM GVRESLEEQT MNMAKATAAL LTEKLRHACG AAVECVISDT  60
   61 CIAGMAEAAA CEEKFSSQNV GLTITVTPCW CYGSETIDMD PTRPKAIWGF NGTERPGAVY 120
  121 LAAALAAHSQ KGIPAFSIYG HDVQDADDTS IPADVEEKLL RFARAGLAVA SMKGKSYLSL 180
  181 GGVSMGIAGS IVDHNFFESW LGMKVQAVDM TELRRRIDQK IYDEAELEMA LAWADKNFRY 240
  241 GEDENNKQYQ RNAEQSRAVL RESLLMAMCI RDMMQGNSKL ADIGRVEESL GYNAIAAGFQ 300
  301 GQRHWTDQYP NGDTAEAILN SSFDWNGVRE PFVVATENDS LNGVAMLMGH QLTGTAQVFA 360
  361 DVRTYWSPEA IERVTGHKLD GLAEHGIIHL INSGSAALDG SCKQRDSEGN PTMKPHWEIS 420
  421 QQEADACLAA TEWCPAIHEY FRGGGYSSRF LTEGGVPFTM TRVNIIKGLG PVLQIAEGWS 480
  481 VELPKDVHDI LNKRTNSTWP TTWFAPRLTG KGPFTDVYSV MANWGANHGV LTIGHVGADF 540
  541 ITLASMLRIP VCMHNVEETK VYRPSAWAAH GMDIEGQDYR ACQNYGPLYK R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1fuiA
Description:	L-fucose isomerase, C-terminal domain; L-fucose isomerase, N-terminal and second domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
L-fucose isomerase activity	4.88986202982249	bayes_pls_golite062009
arabinose isomerase activity	4.88986202982249	bayes_pls_golite062009
intramolecular oxidoreductase activity	1.96654936428522	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	1.46106615677695	bayes_pls_golite062009
catalytic activity	0.767627914425245	bayes_pls_golite062009
binding	0.760545696397943	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: