YRC Public Data Repository - Protein Structure Prediction

Protein:	PTFX1_ECOLI, FRY...
Organism:	Escherichia coli
Length:	831 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTFX1_ECOLI, FRY....

Description	E-value	Query Range	Subject Range
gi\|193069772, gi... - gi\|75235571\|ref\|ZP_00719762.1\| COG1080: Phosphoenolpyruvate-protein kinase (PTS system EI component ...	682.0	[0..1]	[831..1]
gi\|190904428, gi... - gi\|75231329\|ref\|ZP_00717717.1\| COG1080: Phosphoenolpyruvate-protein kinase (PTS system EI component ... gi\|218361694, gi... - gi\|218554926\|ref\|YP_002387839.1\| putative fused PTS enzymes (multiphosphoryl transfer protein): Hpr ...	681.0	[0..1]	[831..1]
gi\|30042043, gi\|... - gi\|30063788\|ref\|NP_837959.1\| putative PTS system enzyme IIA component, enzyme I [Shigella flexneri 2... gi\|110615883, gi... - gi\|110806335\|ref\|YP_689855.1\| putative PTS system enzyme IIA component, enzyme I [Shigella flexneri ...	680.0	[0..1]	[831..1]
gi\|24113741, gi\|... - gi\|24113741\|ref\|NP_708251.1\| putative PTS system enzyme IIA component, enzyme I [Shigella flexneri 2... PTFAX_SHIFL - Multiphosphoryl transfer protein OS=Shigella flexneri GN=fryA PE=3 SV=1	680.0	[0..1]	[831..1]
gi\|157081208, gi... - gi\|75187148\|ref\|ZP_00700415.1\| COG1080: Phosphoenolpyruvate-protein kinase (PTS system EI component ...	680.0	[0..1]	[831..1]
gi\|194428616, gi... - gi\|75210173\|ref\|ZP_00710345.1\| COG1080: Phosphoenolpyruvate-protein kinase (PTS system EI component ...	679.0	[0..1]	[831..1]
gi\|193062334, gi... - gi\|75259825\|ref\|ZP_00731127.1\| COG1080: Phosphoenolpyruvate-protein kinase (PTS system EI component ...	679.0	[0..1]	[831..1]
gi\|251785727, gi... - gi\|251785727\|ref\|YP_003000031.1\| hypothetical protein B21_02254 [Escherichia coli BL21], gi\|24237800... gi\|253974277, gi... - gi\|254162376\|ref\|YP_003045484.1\| fused predicted PTS enzymes: Hpr component/enzyme I component/enzym... gi\|194440138, gi... - gi\|83584533\|ref\|ZP_00923208.1\| COG1080: Phosphoenolpyruvate-protein kinase (PTS system EI component ... gi\|254289137, gi... - gi\|254289137\|ref\|YP_003054885.1\| fused predicted PTS enzymes: Hpr component/enzyme I component/enzym...	678.0	[0..1]	[831..1]
gi\|81246262, gi\|... - gi\|82544851\|ref\|YP_408798.1\| putative PTS system enzyme IIA component, enzyme I [Shigella boydii Sb2...	677.0	[0..1]	[831..1]
gi\|209764410, gi... - pir\|\|A85881 hypothetical protein Z3648 [imported] - Escherichia coli (strain O157:H7, substrain EDL... gi\|189355581, gi... - gi\|189355581\|gb\|EDU74000.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC4401... gi\|188017240, gi... - gi\|188017240\|gb\|EDU55362.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC4113... gi\|15802925, gi\|... - gi\|15802925\|ref\|NP_288953.1\| putative PTS system enzyme IIA component, enzyme I [Escherichia coli O1... gi\|208821095, gi... - gi\|208821095\|ref\|ZP_03261415.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC... gi\|208813004, gi... - gi\|208813004\|ref\|ZP_03254333.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC... gi\|254593745, gi... - gi\|254794345\|ref\|YP_003079182.1\| fused predicted PTS enzymes: Hpr component, enzyme I component, enz... gi\|217320048, gi... - gi\|217327681\|ref\|ZP_03443764.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. TW... gi\|209396468, gi... - gi\|209396468\|ref\|YP_002271869.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. E... gi\|15832517, gi\|... - gi\|15832517\|ref\|NP_311290.1\| putative PTS system enzyme IIA component [Escherichia coli O157:H7 str.... gi\|168800724, gi... - gi\|189377005\|gb\|EDU95421.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC508]... gi\|189372870, gi... - gi\|189372870\|gb\|EDU91286.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC869]... gi\|208728330, gi... - gi\|208808529\|ref\|ZP_03250866.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC... gi\|195938737 - gi\|195938737\|ref\|ZP_03084119.1\| putative PTS system enzyme IIA component [Escherichia coli O157:H7 s... gi\|168770957, gi... - gi\|189360228\|gb\|EDU78647.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC4486... gi\|189366292, gi... - gi\|189366292\|gb\|EDU84708.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC4501... gi\|189002159, gi... - gi\|189002159\|gb\|EDU71145.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC4076... PTFAX_ECO57 - Multiphosphoryl transfer protein OS=Escherichia coli O157:H7 GN=fryA PE=3 SV=1 gi\|168772778, gi... - gi\|187771147\|gb\|EDU34991.1\| multiphosphoryl transfer protein 1 [Escherichia coli O157:H7 str. EC4196...	677.0	[0..1]	[831..1]

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Predicted Domain #1

Region A:
Residues: [1-100]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTIQFLCPL PNGLHARPAW ELKEQCSQWQ SEITFINHRQ NAKADAKSSL ALIGTGTLFN  60
   61 DSCSLNISGS DEEQARRVLE EYIQVRFIDS DSVQPTQAEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1kklH
Description:	Histidine-containing phosphocarrier protein (HPr)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate transmembrane transporter activity	4.19639384083382	bayes_pls_golite062009
transporter activity	2.2402957353057	bayes_pls_golite062009
transmembrane transporter activity	2.10060320724457	bayes_pls_golite062009
substrate-specific transporter activity	1.96035963423233	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.8599676837472	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.85110072198896	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.35834547273032	bayes_pls_golite062009
binding	1.26946317429319	bayes_pls_golite062009
active transmembrane transporter activity	0.929895773411283	bayes_pls_golite062009
protein binding	0.420735403363425	bayes_pls_golite062009
transferase activity	0.368528690162719	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [101-680]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAHPLPRSLS RLNPDLLYGN VLASGVGVGT LTLLQSDSLD SYRAIPASAQ DSTRLEHSLA  60
   61 TLAEQLNQQL RERDGESKTI LSAHLSLIQD DEFAGNIRRL MTEQHQGLGA AIISNMEQVC 120
  121 AKLSASASDY LRERVSDIRD ISEQLLHITW PELKPRNKLV LEKPTILVAE DLTPSQFLSL 180
  181 DLKNLAGMIL EKTGRTSHTL ILARASAIPV LSGLPLDAIA RYAGQPAVLD AQCGVLAINP 240
  241 NDAVSGYYQV AQTLADKRQK QQAQAAAQLA YSRDNKRIDI AANIGTALEA PGAFANGAEG 300
  301 VGLFRTEMLY MDRDSAPDEQ EQFEAYQQVL LAAGDKPIIF RTMDIGGDKS IPYLNIPQEE 360
  361 NPFLGYRAVR IYPEFAGLFR TQLRAILRAA SFGNAQLMIP MVHSLDQILW VKGEIQKAIV 420
  421 ELKRDGLRHA ETITLGIMVE VPSVCYIIDH FCDEVDFFSI GSNDMTQYLY AVDRNNPRVS 480
  481 PLYNPITPSF LRMLQQIVTT AHQRGKWVGI CGELGGESRY LPLLLGLGLD ELSMSSPRIP 540
  541 AVKSQLRQLD SEACRELARQ ACECRSAQEI EALLTAFTPE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	168.0
Match:	2hroA
Description:	No description for 2hroA was found.

Predicted Domain #3

Region A:
Residues: [681-831]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDVRPLLALE NIFVDQDFSN KEQAIQFLCG NLGVNGRTEH PFELEEDVWQ REEIVTTGVG  60
   61 FGVAIPHTKS QWIRHSSISI ARLAKPIGWQ SEMGEVELVI MLTLGANEGM NHVKVFSQLA 120
  121 RKLVNKNFRQ SLFAAQDAQS ILTLLETELT F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.0
Match:	1a3aA
Description:	Phosphotransferase IIa-mannitol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate transmembrane transporter activity	3.38034832098307	bayes_pls_golite062009
transporter activity	2.46214428476465	bayes_pls_golite062009
transmembrane transporter activity	2.33089363600436	bayes_pls_golite062009
substrate-specific transporter activity	2.20510772344576	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.11272911420859	bayes_pls_golite062009
binding	1.09641102479501	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.07132012699244	bayes_pls_golite062009
active transmembrane transporter activity	1.06656635756061	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.731644896465274	bayes_pls_golite062009
ion transmembrane transporter activity	0.639055128751345	bayes_pls_golite062009
protein binding	0.424700469684416	bayes_pls_golite062009
secondary active transmembrane transporter activity	0.199622435240242	bayes_pls_golite062009
antiporter activity	0.00905220946391994	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: