YRC Public Data Repository - Protein Structure Prediction

Protein:	FHUA_ECOLI
Organism:	Escherichia coli
Length:	747 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FHUA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|30039952, gi\|... - gi\|30061710\|ref\|NP_835881.1\| ferrichrome outer membrane transporter [Shigella flexneri 2a str. 2457T... gi\|24050353, gi\|... - gi\|24111588\|ref\|NP_706098.1\| ferrichrome outer membrane transporter [Shigella flexneri 2a str. 301],...	512.0	[0..1]	[747..1]
gi\|124529625, gi... - gi\|124529625\|ref\|ZP_01700569.1\| TonB-dependent siderophore receptor [Escherichia coli B], gi\|1244997... gi\|188487900, gi... - gi\|75512026\|ref\|ZP_00734621.1\| COG1629: Outer membrane receptor proteins, mostly Fe transport [Esche... gi\|194439133, gi... - gi\|83585467\|ref\|ZP_00924112.1\| COG1629: Outer membrane receptor proteins, mostly Fe transport [Esche... gi\|170021496, gi... - gi\|170021496\|ref\|YP_001726450.1\| ferrichrome outer membrane transporter [Escherichia coli ATCC 8739]...	511.0	[0..1]	[747..1]
gi\|81239689, gi\|... - gi\|82775541\|ref\|YP_401888.1\| ferrichrome outer membrane transporter [Shigella dysenteriae Sd197], gi...	511.0	[0..1]	[747..1]
gi\|191172783, gi... - gi\|75240259\|ref\|ZP_00724206.1\| COG1629: Outer membrane receptor proteins, mostly Fe transport [Esche... gi\|226902222, gi... - gi\|237704310\|ref\|ZP_04534791.1\| ferrichrome-iron receptor FhuA [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|91209221, gi\|... - gi\|91209221\|ref\|YP_539207.1\| ferrichrome outer membrane transporter [Escherichia coli UTI89], gi\|910... gi\|110640371, gi... - gi\|110640371\|ref\|YP_668099.1\| ferrichrome outer membrane transporter [Escherichia coli 536], gi\|1103... gi\|218557093, gi... - gi\|218557093\|ref\|YP_002390006.1\| ferrichrome outer membrane transporter [Escherichia coli S88], gi\|2... gi\|115511561, gi... - gi\|117622437\|ref\|YP_851350.1\| ferrichrome outer membrane transporter [Escherichia coli APEC O1], gi\|...	510.0	[0..1]	[747..1]
gi\|13359610, gi\|... - gi\|15829408\|ref\|NP_308181.1\| FhuA [Escherichia coli O157:H7], gi\|13359610\|dbj\|BAB33577.1\| outer memb... gi\|25300760, gi\|... - pir\|\|B90648 outer membrane receptor protein FhuA ECs0154 [imported] - Escherichia coli (strain O157:... gi\|12512871, gi\|... - gi\|15799834\|ref\|NP_285846.1\| ferrichrome outer membrane transporter [Escherichia coli O157:H7 EDL933... gi\|217325934, gi... - gi\|217325934\|ref\|ZP_03442018.1\| ferrichrome-iron receptor [Escherichia coli O157:H7 str. TW14588], g... gi\|189365631, gi... - gi\|189365631\|gb\|EDU84047.1\| ferrichrome-iron receptor [Escherichia coli O157:H7 str. EC4501], gi\|168... gi\|13359610, gi\|... - gi\|15829408\|ref\|NP_308181.1\| ferrichrome outer membrane transporter [Escherichia coli O157:H7 str. S...	510.0	[0..1]	[747..1]
gi\|3445385 - gi\|3445385\|emb\|CAA74395.1\| ferrichrome-iron receptor [Salmonella paratyphi]	505.0	[0..1]	[747..1]
gi\|192959154, gi... - gi\|75238855\|ref\|ZP_00722837.1\| COG1629: Outer membrane receptor proteins, mostly Fe transport [Esche...	503.0	[0..1]	[747..1]
gi\|26106493, gi\|... - gi\|26246096\|ref\|NP_752135.1\| ferrichrome outer membrane transporter [Escherichia coli CFT073], gi\|26... gi\|218425591, gi... - gi\|218688027\|ref\|YP_002396239.1\| ferrichrome outer membrane transporter [Escherichia coli ED1a], gi\|... gi\|227884935, gi... - gi\|227884935\|ref\|ZP_04002740.1\| ferrichrome-iron receptor FhuA [Escherichia coli 83972], gi\|22783807...	497.0	[0..1]	[747..1]
gi\|110804205, gi... - gi\|110804205\|ref\|YP_687725.1\| ferrichrome outer membrane transporter [Shigella flexneri 5 str. 8401]...	486.0	[0..27]	[747..1]
gi\|75176504, gi\|... - gi\|75176504\|ref\|ZP_00696641.1\| COG1629: Outer membrane receptor proteins, mostly Fe transport [Shige...	472.0	[0..1]	[747..1]

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Predicted Domain #1

Region A:
Residues: [1-747]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARSKTAQPK HSLRKIAVVV ATAVSGMSVY AQAAVEPKED TITVTAAPAP QESAWGPAAT  60
   61 IAARQSATGT KTDTPIQKVP QSISVVTAEE MALHQPKSVK EALSYTPGVS VGTRGASNTY 120
  121 DHLIIRGFAA EGQSQNNYLN GLKLQGNFYN DAVIDPYMLE RAEIMRGPVS VLYGKSSPGG 180
  181 LLNMVSKRPT TEPLKEVQFK AGTDSLFQTG FDFSDSLDDD GVYSYRLTGL ARSANAQQKG 240
  241 SEEQRYAIAP AFTWRPDDKT NFTFLSYFQN EPETGYYGWL PKEGTVEPLP NGKRLPTDFN 300
  301 EGAKNNTYSR NEKMVGYSFD HEFNDTFTVR QNLRFAENKT SQNSVYGYGV CSDPANAYSK 360
  361 QCAALAPADK GHYLARKYVV DDEKLQNFSV DTQLQSKFAT GDIDHTLLTG VDFMRMRNDI 420
  421 NAWFGYDDSV PLLNLYNPVN TDFDFNAKDP ANSGPYRILN KQKQTGVYVQ DQAQWDKVLV 480
  481 TLGGRYDWAD QESLNRVAGT TDKRDDKQFT WRGGVNYLFD NGVTPYFSYS ESFEPSSQVG 540
  541 KDGNIFAPSK GKQYEVGVKY VPEDRPIVVT GAVYNLTKTN NLMADPEGSF FSVEGGEIRA 600
  601 RGVEIEAKAA LSASVNVVGS YTYTDAEYTT DTTYKGNTPA QVPKHMASLW ADYTFFDGPL 660
  661 SGLTLGTGGR YTGSSYGDPA NSFKVGSYTV VDALVRYDLA RVGMAGSNVA LHVNNLFDRE 720
  721 YVASCFNTYG CFWGAERQVV ATATFRF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	133.0
Match:	1by3A
Description:	Ferric hydroxamate uptake receptor FhuA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	4.15398171369398	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	3.71720155502729	bayes_pls_golite062009
metal ion transmembrane transporter activity	3.51478170290895	bayes_pls_golite062009
cation transmembrane transporter activity	3.41811856763345	bayes_pls_golite062009
ion transmembrane transporter activity	3.35817595849318	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.29933669641504	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.88478677770584	bayes_pls_golite062009
iron ion transmembrane transporter activity	2.78006545332604	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	2.64234123687059	bayes_pls_golite062009
substrate-specific transporter activity	2.43332676180972	bayes_pls_golite062009
transmembrane transporter activity	1.99898520864149	bayes_pls_golite062009
porin activity	0.896682978257159	bayes_pls_golite062009
binding	0.643879907209189	bayes_pls_golite062009
channel activity	0.491712690153616	bayes_pls_golite062009
passive transmembrane transporter activity	0.491712690153616	bayes_pls_golite062009
lipid transporter activity	0.10911346172326	bayes_pls_golite062009
protein binding	0.0112080975548029	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: