YRC Public Data Repository - Protein Structure Prediction

Protein:	SO1030
Organism:	Shewanella oneidensis
Length:	1244 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SO1030.

Description	E-value	Query Range	Subject Range
gi\|117614052, gi... - gi\|78684694\|ref\|ZP_00849477.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Shewanella ...	1536.0	[0..1]	[1244..1]
gi\|113890117, gi... - gi\|78688773\|ref\|ZP_00853440.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Shewanella ...	1533.0	[0..1]	[1244..1]
gi\|113883866, gi... - gi\|82495062\|ref\|ZP_00880640.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Shewanella ...	1531.0	[0..1]	[1244..1]
gi\|120557905, gi... - gi\|82741988\|ref\|ZP_00904695.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Shewanella ...	1524.0	[0..1]	[1244..1]
gi\|113908634, gi... - gi\|113949026\|ref\|ZP_01434680.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Shewanella...	1510.0	[0..12]	[1244..1]
METH_VIBPA - Methionine synthase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=metH PE=3 SV=... gi\|153840028, gi... - gi\|153840028\|ref\|ZP_01992695.1\| methionine synthase [Vibrio parahaemolyticus AQ3810], gi\|149746415\|g... METH_VIBPA - Methionine synthase OS=Vibrio parahaemolyticus GN=metH PE=3 SV=1	1504.0	[0..8]	[1240..2]
METH_ALIFS - Methionine synthase OS=Aliivibrio fischeri GN=metH PE=3 SV=1	1501.0	[0..7]	[1240..2]
gi\|125621484, gi... - gi\|75819730\|ref\|ZP_00749797.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol...	1501.0	[0..8]	[1240..2]
gi\|254223014, gi... - gi\|254223014\|ref\|ZP_04916876.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... tr\|D7HD92\|D7HD92... - 5-methyltetrahydrofolate-homocysteine methyltransferase OS=Vibrio cholerae RC385 GN=VCRC385_00259 PE...	1500.0	[0..8]	[1240..2]
gi\|121630369, gi... - gi\|75816808\|ref\|ZP_00747268.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol... gi\|121548155, gi... - gi\|121587582\|ref\|ZP_01677347.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|124118339, gi... - gi\|153223242\|ref\|ZP_01953739.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|126520229, gi... - gi\|229508815\|ref\|ZP_04398307.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... METH_VIBCH - Methionine synthase OS=Vibrio cholerae GN=metH PE=3 SV=1 gi\|227080601, gi... - gi\|227080601\|ref\|YP_002809152.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio ch... gi\|229344492, gi... - gi\|229519803\|ref\|ZP_04409246.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio cho... gi\|229368983, gi... - gi\|229606328\|ref\|YP_002876976.1\| 5-methyltetrahydrofolate--homocysteine methyltransferase [Vibrio ch... gi\|254850622, gi... - gi\|75829069\|ref\|ZP_00758388.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol... METH_VIBCH - Methionine synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=metH... gi\|75828368, gi\|... - gi\|75828368\|ref\|ZP_00757803.1\| COG1410: Methionine synthase I, cobalamin-binding domain [Vibrio chol...	1499.0	[0..8]	[1240..2]

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Predicted Domain #1

Region A:
Residues: [1-619]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAISPNRASH TLADIRNQLS TRILILDGAM GTMIQGYKLE EADYRGERFK DWHTDVKGNN  60
   61 DLLVLTQPHI IKQIHTDYLL AGADIIETNT FNATTIAMAD YDMQSLSAEI NREGARLARE 120
  121 ACDAIEQATG KPRYVAGVLG PTNRTCSISP DVNDPGFRNI HFDELVTAYC ESTRALIEGG 180
  181 ADIIMVETIF DTLNAKAALF AIETVFDELF GANSPARLPV MISGTITDAS GRTLTGQTTE 240
  241 AFYNSLRHIK PLSIGLNCAL GPKELRPYVE ELSRIAECYV SAHPNAGLPN EFGGYDETPE 300
  301 DMAKVIQEWA REGMLNIIGG CCGSTPEHIK VIREAVEQFA PRVLPEIPVA CRLAGLEPLT 360
  361 IDAQTLFVNV GERTNVTGSA KFLKLIKEGK FEQALDVARE QVESGAQIID INMDEGMLDG 420
  421 VEIMHKFLNL IASEPDISRV PIMIDSSKWE VIEAGLKCIQ GKGIVNSISL KEGEEKFIEQ 480
  481 ATLVKRYGAA AIIMAFDEQG QADTKARKVE ICTRAYRVLV DKVGFPPEDI IFDPNIFAIA 540
  541 TGIDEHDNYA VDFIDAIKEI KATLPHAMIS GGVSNVSFSF RGNNPVREAI HAVFLYHAIK 600
  601 VGMDMGIVNA GQLAIFDDI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	112.0
Match:	1q7mA
Description:	Cobalamin-dependent methionine synthase (MetH) from Thermotoga maritima (Oxidized, Monoclinic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydropteroate synthase activity	5.55484533231129	bayes_pls_golite062009
S-methyltransferase activity	3.53817178180686	bayes_pls_golite062009
methyltransferase activity	3.47355858135695	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.39246539615995	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.30536381024187	bayes_pls_golite062009
transferase activity	2.35234138809715	bayes_pls_golite062009
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	1.59882258515727	bayes_pls_golite062009
catalytic activity	1.41033217274476	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.09502814971491	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.775834109629976	bayes_pls_golite062009
binding	0.660910809839792	bayes_pls_golite062009
dihydroneopterin aldolase activity	0.570043482286316	bayes_pls_golite062009
protein binding	0.422094211438801	bayes_pls_golite062009
diphosphotransferase activity	0.246882532482481	bayes_pls_golite062009
methionine synthase activity	0.191040886553873	bayes_pls_golite062009
5-methyltetrahydrofolate-dependent methyltransferase activity	0.191040886553873	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [620-652]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPELKVRVEN VVLNLPCPVE GSNNTEQLLE IAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	49.522879
Match:	5reqA
Description:	Methylmalonyl-CoA mutase alpha subunit, domain 1; Methylmalonyl-CoA mutase alpha subunit, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [653-1244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFRGDGSSSA KKEDLEWRSW PVNQRLAHAL VKGITEFIDE DTEAARQAAS RPLDVIEGPL  60
   61 MDGMNIVGDL FGSGKMFLPQ VVKSARVMKK AVAYLNPFIE KEKVAGQSNG KILMVTVKSD 120
  121 VHDIGKNIVG VVLACNGFEV FDLGVMVSVE RILEAVKEHN IDIIGMSGLI TPSLDEMVHN 180
  181 VKTFHREGLT IPAIIGGATC SKIHTAVKIA PHYPHGAIYI ADASRAVPMV SKLVNNETRQ 240
  241 ATIDETYAEY DDMRTKRLSQ AKRKEIVSLE AARENRCQHD WANYSPFKPN VLGRQVFDDY 300
  301 PLTDLVDRID WTPFFRAWEL HGHYPEILSD KVVGVEAQKL FSDGKAMLKK IIEEKWLTAK 360
  361 GVIGLFPANT VGFDDIELYT DETRTEVELT THHLRMQLER VGNDNFCLAD FVAPKDSGVA 420
  421 DYMGGFAVTA GHGIDEHVAR FEANHDDYNA IMLKCLADRL AEAFAERMHE RVRKEFWGYA 480
  481 ADEQLDNEAL IREKYKGIRP APGYPACPDH TEKGLLWELL KPNETIDLNI TESYAMFPTA 540
  541 AVSGWYFAHP KSRYFGVSNI GRDQVEDYAK RKGMTVAETE KWLAPVLDYD PE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1k7yA
Description:	Methionine synthase domain; Methionine synthase, C-terminal domain; Methionine synthase SAM-binding domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: