YRC Public Data Repository - Protein Structure Prediction

Protein:	EMRK_ECOLI
Organism:	Escherichia coli
Length:	387 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMRK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|13362717, gi\|... - gi\|15832501\|ref\|NP_311274.1\| multidrug resistance protein K [Escherichia coli O157:H7 str. Sakai], g... gi\|168763543, gi... - gi\|189366310\|gb\|EDU84726.1\| drug resistance MFS transporter, membrane fusion protein (MFP) subunit E... gi\|13362717, gi\|... - gi\|15832501\|ref\|NP_311274.1\| multidrug resistance protein K [Escherichia coli O157:H7], gi\|13362717\|... gi\|25323906, gi\|... - pir\|\|A85879 multidrug resistance protein K [imported] - Escherichia coli (strain O157:H7, substrain ... gi\|15802911, gi\|... - gi\|15802911\|ref\|NP_288938.1\| multidrug resistance protein K [Escherichia coli O157:H7 EDL933], gi\|12... gi\|217326976, gi... - gi\|217326976\|ref\|ZP_03443059.1\| drug resistance MFS transporter, membrane fusion protein (MFP) subun...	254.0	[0..1]	[386..1]
gi\|11350621 - pir\|\|D83002 multidrug resistance protein PA5159 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|9951460, gi\|1... - gi\|9951460\|gb\|AAG08544.1\|AE004928_10 multidrug resistance protein [Pseudomonas aeruginosa PAO1], gi\|...	254.0	[0..6]	[358..8]
gi\|82777771, gi\|... - gi\|82777771\|ref\|YP_404120.1\| multidrug resistance protein K [Shigella dysenteriae Sd197], gi\|8124191...	253.0	[0..1]	[386..1]
gi\|73856393, gi\|... - gi\|74312916\|ref\|YP_311335.1\| multidrug resistance protein K [Shigella sonnei Ss046], gi\|73856393\|gb\|...	253.0	[0..1]	[386..1]
gi\|81246247, gi\|... - gi\|82544836\|ref\|YP_408783.1\| multidrug resistance protein K [Shigella boydii Sb227], gi\|81246247\|gb\|...	253.0	[0..1]	[386..1]
gi\|3414725 - gi\|3414725\|gb\|AAC31387.1\| multidrug resistance efflux pump homolog PmrA [Pseudomonas aeruginosa] gi\|3414725\|gb\|AA... - multidrug resistance efflux pump homolog PmrA [Pseudomonas aeruginosa]	252.0	[0..6]	[358..8]
gi\|110806321, gi... - gi\|110806321\|ref\|YP_689841.1\| multidrug resistance protein K [Shigella flexneri 5 str. 8401], gi\|110... gi\|24113729, gi\|... - gi\|24113729\|ref\|NP_708239.1\| multidrug resistance protein K [Shigella flexneri 2a str. 301], gi\|2405... gi\|30063775, gi\|... - gi\|30063775\|ref\|NP_837946.1\| multidrug resistance protein K [Shigella flexneri 2a str. 2457T], gi\|30...	251.0	[0..1]	[386..1]
gi\|227835767, gi... - gi\|227887417\|ref\|ZP_04005222.1\| MFP family membrane fusion protein [Escherichia coli 83972], gi\|2278... gi\|26109152, gi\|... - gi\|26248746\|ref\|NP_754786.1\| multidrug resistance protein K [Escherichia coli CFT073], gi\|26109152\|g...	250.0	[0..1]	[386..1]
gi\|91073285, gi\|... - gi\|91211711\|ref\|YP_541697.1\| multidrug resistance protein K [Escherichia coli UTI89], gi\|91073285\|gb... gi\|218428075, gi... - gi\|218690511\|ref\|YP_002398723.1\| EmrKY-TolC multidrug resistance efflux pump, membrane fusion protei... gi\|237704893, gi... - gi\|237704893\|ref\|ZP_04535374.1\| multidrug resistance protein K [Escherichia sp. 3_2_53FAA], gi\|22690...	249.0	[0..1]	[386..1]
gi\|46445762, gi\|... - gi\|46445762\|ref\|YP_007127.1\| multidrug resistance protein, emrA [Candidatus Protochlamydia amoebophi...	246.0	[0..9]	[343..22]

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Predicted Domain #1

Region A:
Residues: [1-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQINSNKKH SNRRKYFSLL AVVLFIAFSG AYAYWSMELE DMISTDDAYV TGNADPISAQ  60
   61 VSGSVTVVNH KDTNYVRQGD ILVSLDKTDA TIALNKAKNN LANIVRQTNK LYLQDKQYSA 120
  121 EVASARIQYQ QSLEDYNRRV PLAKQGVISK ETLEHTKDTL ISSKAALNAA IQAYKANKAL 180
  181 VMNTPLNRQP QVVEAADATK EAWLALKRTD IKSPVTGYIA QRSVQVGETV SPGQSLMAVV 240
  241 PARQMWVNAN FKETQLTDVR IGQSVNIISD LYGENVVFHG RVTGINMGTG NAFSLLPAQN 300
  301 ATGNWIKIVQ RVPVEVSLDP KELMEHPLRI GLSMTATIDT KNEDIAEMPE LASTVTSMPA 360
  361 YTSKALVIDT SPIEKEISNI ISHNGQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.30103
Match:	1t5eA
Description:	The structure of MexA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
drug transmembrane transporter activity	6.72943251269963	bayes_pls_golite062009
	6.35210689530056	bayes_pls_golite062009
	6.27508108329198	bayes_pls_golite062009
transporter activity	4.64829294279324	bayes_pls_golite062009
transmembrane transporter activity	3.3430410220484	bayes_pls_golite062009
protein transporter activity	2.78337364594901	bayes_pls_golite062009
substrate-specific transporter activity	2.32388774487807	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.892013812755237	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.729251657794536	bayes_pls_golite062009
ion transmembrane transporter activity	0.696350598512404	bayes_pls_golite062009
cation transmembrane transporter activity	0.560994844134224	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: