YRC Public Data Repository - Protein Structure Prediction

Protein:	DAPE_ECOLI
Organism:	Escherichia coli
Length:	375 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DAPE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75240121, gi\|... - gi\|75240121\|ref\|ZP_00724080.1\| COG0624: Acetylornithine deacetylase/Succinyl-diaminopimelate desucci... DAPE_ECOL5 - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=dapE PE...	349.0	[0..1]	[375..1]
DAPE_SHIB3 - Succinyl-diaminopimelate desuccinylase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) G...	349.0	[0..1]	[375..1]
gi\|191167646, gi... - gi\|75229206\|ref\|ZP_00715774.1\| COG0624: Acetylornithine deacetylase/Succinyl-diaminopimelate desucci... DAPE_ECOSE - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli (strain SE11) GN=dapE PE=3 SV=1	349.0	[0..1]	[375..1]
gi\|194432072, gi... - gi\|83570687\|ref\|ZP_00922130.1\| COG0624: Acetylornithine deacetylase/Succinyl-diaminopimelate desucci...	349.0	[0..1]	[375..1]
gi\|226901354, gi... - gi\|237704988\|ref\|ZP_04535469.1\| succinyl-diaminopimelate desuccinylase [Escherichia sp. 3_2_53FAA], ... gi\|227835860, gi... - gi\|227887510\|ref\|ZP_04005315.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli 83972], gi\|... DAPE_ECOL6 - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC... DAPE_ECOL6 - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli O6 GN=dapE PE=3 SV=1 DAPE_ECOK1 - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli O1:K1 / APEC GN=dapE PE=3 SV=1 DAPE_ECOUT - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli (strain UTI89 / UPEC) GN=dapE PE=3 SV=1 DAPE_ECO45 - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=dapE PE=3 ...	349.0	[0..1]	[375..1]
DAPE_SHISS - Succinyl-diaminopimelate desuccinylase OS=Shigella sonnei (strain Ss046) GN=dapE PE=3 SV=1	349.0	[0..1]	[375..1]
DAPE_BORPA - Succinyl-diaminopimelate desuccinylase OS=Bordetella parapertussis GN=dapE PE=3 SV=1 DAPE_BORPA - Succinyl-diaminopimelate desuccinylase OS=Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NC...	348.0	[0..2]	[374..3]
gi\|193068374, gi... - gi\|75237785\|ref\|ZP_00721801.1\| COG0624: Acetylornithine deacetylase/Succinyl-diaminopimelate desucci...	348.0	[0..1]	[375..1]
DAPE_ECO57 - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli O157:H7 GN=dapE PE=3 SV=1 gi\|209763760, gi... - pir\|\|A85890 N-succinyl-diaminopimelate deacylase [imported] - Escherichia coli (strain O157:H7, subs... gi\|254593816, gi... - gi\|254794416\|ref\|YP_003079253.1\| N-succinyl-diaminopimelate deacylase [Escherichia coli O157:H7 str.... gi\|15802994, gi\|... - gi\|15802994\|ref\|NP_289024.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 EDL933... DAPE_ECO5E - Succinyl-diaminopimelate desuccinylase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=dapE PE... gi\|208740970, gi... - gi\|208820847\|ref\|ZP_03261167.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str... gi\|217319879, gi... - gi\|217327512\|ref\|ZP_03443595.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str... gi\|195936613 - gi\|195936613\|ref\|ZP_03081995.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str... gi\|168798837, gi... - gi\|189378637\|gb\|EDU97053.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|208733873, gi... - gi\|208812596\|ref\|ZP_03253925.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str... gi\|208729185, gi... - gi\|208809384\|ref\|ZP_03251721.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str... gi\|168773620, gi... - gi\|187770666\|gb\|EDU34510.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|189362299, gi... - gi\|189362299\|gb\|EDU80718.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|168787812, gi... - gi\|189372314\|gb\|EDU90730.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|189003182, gi... - gi\|189003182\|gb\|EDU72168.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|168748475, gi... - gi\|188017094\|gb\|EDU55216.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|189368452, gi... - gi\|189368452\|gb\|EDU86868.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|189356596, gi... - gi\|189356596\|gb\|EDU75015.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. EC... gi\|13362804, gi\|... - gi\|15832588\|ref\|NP_311361.1\| succinyl-diaminopimelate desuccinylase [Escherichia coli O157:H7 str. S...	348.0	[0..1]	[375..1]
DAPE_SHIF8 - Succinyl-diaminopimelate desuccinylase OS=Shigella flexneri serotype 5b (strain 8401) GN=dapE PE=3 S...	347.0	[0..1]	[375..1]

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Predicted Domain #1

Region A:
Residues: [1-375]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCPVIELTQ QLIRRPSLSP DDAGCQALLI ERLQAIGFTV ERMDFADTQN FWAWRGQGET  60
   61 LAFAGHTDVV PPGDADRWIN PPFEPTIRDG MLFGRGAADM KGSLAAMVVA AERFVAQHPN 120
  121 HTGRLAFLIT SDEEASAHNG TVKVVEALMA RNERLDYCLV GEPSSIEVVG DVVKNGRRGS 180
  181 LTCNLTIHGV QGHVAYPHLA DNPVHRAAPF LNELVAIEWD QGNEFFPATS MQIANIQAGT 240
  241 GSNNVIPGEL FVQFNFRFST ELTDEMIKAQ VLALLEKHQL RYTVDWWLSG QPFLTARGKL 300
  301 VDAVVNAVEH YNEIKPQLLT TGGTSDGRFI ARMGAQVVEL GPVNATIHKI NECVNAADLQ 360
  361 LLARMYQRIM EQLVA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.69897
Match:	1vgyA
Description:	Crystal structure of succinyl diaminopimelate desuccinylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.53599751822623	bayes_pls_golite062009
hydrolase activity	3.17104798571343	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	2.83557334423635	bayes_pls_golite062009
catalytic activity	2.00064748759729	bayes_pls_golite062009
exopeptidase activity	0.960517137038552	bayes_pls_golite062009
binding	0.456088952797852	bayes_pls_golite062009
carboxypeptidase activity	0.389857234977383	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: