YRC Public Data Repository - Protein Structure Prediction

Protein:	CYSB_ECOLI
Organism:	Escherichia coli
Length:	324 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYSB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|24112672, gi\|... - gi\|24112672\|ref\|NP_707182.1\| transcriptional regulator CysB [Shigella flexneri 2a str. 301], gi\|2405... gi\|30041045, gi\|... - gi\|30062797\|ref\|NP_836968.1\| transcriptional regulator CysB [Shigella flexneri 2a str. 2457T], gi\|30... gi\|110805276, gi... - gi\|110805276\|ref\|YP_688796.1\| transcriptional regulator CysB [Shigella flexneri 5 str. 8401], gi\|110...	271.0	[0..1]	[324..1]
gi\|81240782, gi\|... - gi\|82776634\|ref\|YP_402983.1\| transcriptional regulator CysB [Shigella dysenteriae Sd197], gi\|8124078...	270.0	[0..1]	[324..1]
gi\|74312356, gi\|... - gi\|74312356\|ref\|YP_310775.1\| transcriptional regulator CysB [Shigella sonnei Ss046], gi\|73855833\|gb\|...	270.0	[0..1]	[324..1]
gi\|238894332, gi... - gi\|238894332\|ref\|YP_002919066.1\| transcriptional regulator for cysteine regulon [Klebsiella pneumoni... gi\|628813 - gi\|628813\|pir\|\|S43835 regulatory protein cysB - Klebsiella sp. (ATCC 15380) CYSB_KLEAE - (P45600) HTH-type transcriptional regulator cysB (Cys regulon transcriptional activator) CYSB_KLEPN - HTH-type transcriptional regulator CysB OS=Klebsiella pneumoniae GN=cysB PE=1 SV=2 gi\|152969825, gi... - gi\|152969825\|ref\|YP_001334934.1\| transcriptional regulator CysB [Klebsiella pneumoniae subsp. pneumo...	269.0	[0..1]	[324..1]
gi\|511012 - gi\|511012\|emb\|CAA55380.1\| CYSB protein [Klebsiella aerogenes]	269.0	[0..1]	[324..1]
gi\|194458733, gi... - gi\|194472369\|ref\|ZP_03078353.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ... gi\|197249782, gi... - gi\|197249782\|ref\|YP_002146314.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp.... gi\|197262598, gi... - gi\|197262598\|ref\|ZP_03162672.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ... gi\|205272394, gi... - gi\|205352613\|ref\|YP_002226414.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica... gi\|205350846, gi... - gi\|205350846\|gb\|EDZ37477.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ente... gi\|195634558, gi... - gi\|195634558\|gb\|EDX52910.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ente... gi\|168819533, gi... - gi\|205343792\|gb\|EDZ30556.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ente... gi\|194449730, gi... - gi\|194449730\|ref\|YP_002045759.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica... CYSB_SALTY - HTH-type transcriptional regulator cysB OS=Salmonella typhimurium GN=cysB PE=1 SV=1 gi\|205325067, gi... - gi\|205325067\|gb\|EDZ12906.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ente... gi\|167993765, gi... - gi\|205328284\|gb\|EDZ15048.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ente... gi\|168230149, gi... - gi\|205335560\|gb\|EDZ22324.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ente... gi\|205339414, gi... - gi\|205339414\|gb\|EDZ26178.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp. ente... CYSB_SALTY - HTH-type transcriptional regulator CysB OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7007... CYSB_SALTY - HTH-type transcriptional regulator CysB OS=Salmonella typhimurium GN=cysB PE=1 SV=1 lcl\|NC_016856.1_... - [gene=cysB] [protein=transcriptional regulator CysB] [protein_id=YP_005237636.1] [location=complemen... gi\|207856774, gi... - gi\|207856774\|ref\|YP_002243425.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica... gi\|238911895 - gi\|238911895\|ref\|ZP_04655732.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ...	267.0	[0..1]	[324..1]
gi\|16502461, gi\|... - gi\|25301166\|pir\|\|AG0654 cys regulon transcription activator STY1337 [imported] - Salmonella enterica... gi\|29142062, gi\|... - gi\|29142062\|ref\|NP_805404.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ser... gi\|16760167 - gi\|16760167\|ref\|NP_455784.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ser... gi\|194403967, gi... - gi\|194445304\|ref\|YP_002040966.1\| HTH-type transcriptional regulator CysB [Salmonella enterica subsp.... gi\|213852107 - gi\|213852107\|ref\|ZP_03381639.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ... gi\|213647990 - gi\|213647990\|ref\|ZP_03378043.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ... gi\|213424429 - gi\|213424429\|ref\|ZP_03357242.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ... gi\|213162272 - gi\|213162272\|ref\|ZP_03347982.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ...	267.0	[0..1]	[324..1]
gi\|56413361, gi\|... - gi\|56413361\|ref\|YP_150436.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica ser... gi\|197362285, gi... - gi\|197362285\|ref\|YP_002141922.1\| transcriptional regulator CysB [Salmonella enterica subsp. enterica...	266.0	[0..1]	[324..1]
gi\|36785760, gi\|... - gi\|37526329\|ref\|NP_929673.1\| transcriptional regulator CysB [Photorhabdus luminescens subsp. laumond...	265.0	[0..1]	[323..1]
gi\|91227575, gi\|... - gi\|91227575\|ref\|ZP_01261879.1\| transcriptional regulator for cysteine regulon [Vibrio alginolyticus ...	264.0	[0..1]	[324..1]

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Predicted Domain #1

Region A:
Residues: [1-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLQQLRYIV EVVNHNLNVS STAEGLYTSQ PGISKQVRML EDELGIQIFS RSGKHLTQVT  60
   61 PAGQEIIRIA REVLSKVDAI KSVAGEHTWP DKGSLYIATT HTQARYALPN VIKGFIERYP 120
  121 RVSLHMHQGS PTQIADAVSK GNADFAIATE ALHLYEDLVM LPCYHWNRAI VVTPDHPLAG 180
  181 KKAITIEELA QYPLVTYTFG FTGRSELDTA FNRAGLTPRI VFTATDADVI KTYVRLGLGV 240
  241 GVIASMAVDP VADPDLVRVD AHDIFSHSTT KIGFRRSTFL RSYMYDFIQR FAPHLTRDVV 300
  301 DAAVALRSNE EIEVMFKDIK LPEK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.154902
Match:	1al3A
Description:	COFACTOR BINDING FRAGMENT OF CYSB FROM KLEBSIELLA AEROGENES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.06846313752146	bayes_pls_golite062009
transcription factor activity	1.54776226622667	bayes_pls_golite062009
DNA binding	1.53867658911479	bayes_pls_golite062009
nucleic acid binding	1.45471488657915	bayes_pls_golite062009
binding	1.29220115989941	bayes_pls_golite062009
catalytic activity	1.04475291968158	bayes_pls_golite062009
protein binding	0.0639574144110515	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: