YRC Public Data Repository - Protein Structure Prediction

Protein:	CUSB_ECOLI
Organism:	Escherichia coli
Length:	407 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUSB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|114772337 - gi\|114772337\|ref\|ZP_01449712.1\| putative cation efflux system protein [alpha proteobacterium HTCC225... gi\|221134444 - gi\|221134444\|ref\|ZP_03560749.1\| membrane-fusion protein-like [Glaciecola sp. HTCC2999] gi\|114547067, gi... - gi\|114772337\|ref\|ZP_01449712.1\| putative cation efflux system protein [alpha proteobacterium HTCC225...	284.0	[0..1]	[406..1]
gi\|110599168, gi... - gi\|222055653\|ref\|YP_002538015.1\| efflux transporter, RND family, MFP subunit [Geobacter sp. FRC-32],...	279.0	[0..2]	[392..5]
gi\|89951175, gi\|... - gi\|90021575\|ref\|YP_527402.1\| membrane-fusion protein-like [Saccharophagus degradans 2-40], gi\|899511...	278.0	[0..1]	[389..1]
gi\|83570407, gi\|... - gi\|83570407\|ref\|ZP_00921852.1\| COG0845: Membrane-fusion protein [Shigella dysenteriae 1012], gi\|1944...	275.0	[0..1]	[407..1]
gi\|71839529, gi\|... - gi\|71839529\|ref\|ZP_00679276.1\| Secretion protein HlyD [Pelobacter propionicus DSM 2379], gi\|71740000...	274.0	[0..2]	[407..4]
gi\|88703745, gi\|... - gi\|88703745\|ref\|ZP_01101461.1\| cation efflux system transmembrane protein [gamma proteobacterium KT ...	273.0	[0..2]	[402..6]
gi\|75227375, gi\|... - gi\|75227375\|ref\|ZP_00714153.1\| COG0845: Membrane-fusion protein [Escherichia coli B7A], gi\|191169322...	272.0	[0..1]	[407..1]
gi\|190907420, gi... - gi\|75240731\|ref\|ZP_00724638.1\| COG0845: Membrane-fusion protein [Escherichia coli F11], gi\|191172321... gi\|110640804, gi... - gi\|110640804\|ref\|YP_668532.1\| copper/silver efflux system membrane fusion protein CusB [Escherichia ...	272.0	[0..1]	[407..1]
CUSB_ECOL6 - Cation efflux system protein CusB OS=Escherichia coli O6 GN=cusB PE=2 SV=1 CUSB_ECOL6 - Cation efflux system protein CusB OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=... gi\|227884448, gi... - gi\|227884448\|ref\|ZP_04002253.1\| copper/silver efflux system membrane fusion protein CusB [Escherichi... gi\|215485616, gi... - gi\|215485616\|ref\|YP_002328047.1\| copper/silver efflux system membrane fusion protein CusB [Escherich...	272.0	[0..1]	[407..1]

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Predicted Domain #1

Region A:
Residues: [1-407]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKIALIIGS MIAGGIISAA GFTWVAKAEP PAEKTSTAER KILFWYDPMY PNTRFDKPGK  60
   61 SPFMDMDLVP KYADEESSAS GVRIDPTQTQ NLGVKTATVT RGPLTFAQSF PANVSYNEYQ 120
  121 YAIVQARAAG FIDKVYPLTV GDKVQKGTPL LDLTIPDWVE AQSEYLLLRE TGGTATQTEG 180
  181 ILERLRLAGM PEADIRRLIA TQKIQTRFTL KAPIDGVITA FDLRAGMNIA KDNVVAKIQG 240
  241 MDPVWVTAAI PESIAWLVKD ASQFTLTVPA RPDKTLTIRK WTLLPGVDAA TRTLQLRLEV 300
  301 DNADEALKPG MNAWLQLNTA SEPMLLIPSQ ALIDTGSEQR VITVDADGRF VPKRVAVFQA 360
  361 SQGVTALRSG LAEGEKVVSS GLFLIDSEAN ISGALERMRS ESATHAH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.39794
Match:	1t5eA
Description:	The structure of MexA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	3.09938670564647	bayes_pls_golite062009
transmembrane transporter activity	1.76901190838739	bayes_pls_golite062009
drug transmembrane transporter activity	1.19779068377897	bayes_pls_golite062009
	1.11499578803433	bayes_pls_golite062009
ion transmembrane transporter activity	1.0426999541604	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.03250626584085	bayes_pls_golite062009
cation transmembrane transporter activity	1.01684447681598	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.937335161849607	bayes_pls_golite062009
	0.8928263262356	bayes_pls_golite062009
substrate-specific transporter activity	0.49683979228193	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: