YRC Public Data Repository - Protein Structure Prediction

Protein:	CUEO_ECOLI
Organism:	Escherichia coli
Length:	516 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUEO_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|237704278, gi... - gi\|237704278\|ref\|ZP_04534759.1\| blue copper oxidase CueO [Escherichia sp. 3_2_53FAA], gi\|226902190\|g... gi\|91070765, gi\|... - gi\|91209191\|ref\|YP_539177.1\| blue copper oxidase CueO precursor [Escherichia coli UTI89], gi\|9107076...	393.0	[0..1]	[516..14]
gi\|26106460, gi\|... - gi\|26246063\|ref\|NP_752102.1\| Blue copper oxidase cueO precursor [Escherichia coli CFT073], gi\|261064...	391.0	[0..1]	[516..14]
gi\|117622410, gi... - gi\|117622410\|ref\|YP_851323.1\| multicopper oxidase [Escherichia coli APEC O1], gi\|115511534\|gb\|ABI996... gi\|162138501 - gi\|162138501\|ref\|YP_539177.2\| multicopper oxidase [Escherichia coli UTI89] gi\|218557066, gi... - gi\|218557066\|ref\|YP_002389979.1\| multicopper oxidase [Escherichia coli S88], gi\|218363835\|emb\|CAR014...	389.0	[0..1]	[516..1]
gi\|75240285, gi\|... - gi\|75240285\|ref\|ZP_00724232.1\| COG2132: Putative multicopper oxidases [Escherichia coli F11], gi\|191...	388.0	[0..1]	[516..1]
gi\|81244137, gi\|... - gi\|82542726\|ref\|YP_406673.1\| multicopper oxidase [Shigella boydii Sb227], gi\|81244137\|gb\|ABB64845.1\|... gi\|75176528 - gi\|75176528\|ref\|ZP_00696665.1\| COG2132: Putative multicopper oxidases [Shigella boydii BS512]	387.0	[0..1]	[516..1]
gi\|110640341, gi... - gi\|110640341\|ref\|YP_668069.1\| multicopper oxidase [Escherichia coli 536], gi\|110341933\|gb\|ABG68170.1...	387.0	[0..1]	[516..1]
gi\|83569704, gi\|... - gi\|83569704\|ref\|ZP_00921154.1\| COG2132: Putative multicopper oxidases [Shigella dysenteriae 1012], g...	387.0	[0..1]	[516..1]
gi\|209746226, gi... - pir\|\|G85495 hypothetical protein yacK [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15799807, gi\|... - gi\|15799807\|ref\|NP_285819.1\| multicopper oxidase [Escherichia coli O157:H7 EDL933], gi\|12512835\|gb\|A... gi\|168764735, gi... - gi\|189365326\|gb\|EDU83742.1\| copper oxidase CueO [Escherichia coli O157:H7 str. EC4501], gi\|168764735... CUEO_ECO57 - Blue copper oxidase CueO OS=Escherichia coli O157:H7 GN=cueO PE=3 SV=1 gi\|13359583, gi\|... - gi\|15829381\|ref\|NP_308154.1\| multicopper oxidase [Escherichia coli O157:H7 str. Sakai], gi\|13359583\|... gi\|217320637, gi... - gi\|217324416\|ref\|ZP_03440500.1\| copper oxidase CueO [Escherichia coli O157:H7 str. TW14588], gi\|2173...	387.0	[0..1]	[516..1]
gi\|83585442, gi\|... - gi\|83585442\|ref\|ZP_00924087.1\| COG2132: Putative multicopper oxidases [Escherichia coli 101-1], gi\|1...	387.0	[0..1]	[516..1]
gi\|192931064, gi... - gi\|75258884\|ref\|ZP_00730274.1\| COG2132: Putative multicopper oxidases [Escherichia coli E22], gi\|193... gi\|75210450, gi\|... - gi\|75210450\|ref\|ZP_00710601.1\| COG2132: Putative multicopper oxidases [Escherichia coli B171], gi\|19... gi\|75194338 - gi\|75194338\|ref\|ZP_00704408.1\| COG2132: Putative multicopper oxidases [Escherichia coli HS] gi\|75189222 - gi\|75189222\|ref\|ZP_00702489.1\| COG2132: Putative multicopper oxidases [Escherichia coli E24377A]	386.0	[0..1]	[516..1]

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Predicted Domain #1

Region A:
Residues: [1-516]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRRDFLKYS VALGVASALP LWSRAVFAAE RPTLPIPDLL TTDARNRIQL TIGAGQSTFG  60
   61 GKTATTWGYN GNLLGPAVKL QRGKAVTVDI YNQLTEETTL HWHGLEVPGE VDGGPQGIIP 120
  121 PGGKRSVTLN VDQPAATCWF HPHQHGKTGR QVAMGLAGLV VIEDDEILKL MLPKQWGIDD 180
  181 VPVIVQDKKF SADGQIDYQL DVMTAAVGWF GDTLLTNGAI YPQHAAPRGW LRLRLLNGCN 240
  241 ARSLNFATSD NRPLYVIASD GGLLPEPVKV SELPVLMGER FEVLVEVNDN KPFDLVTLPV 300
  301 SQMGMAIAPF DKPHPVMRIQ PIAISASGAL PDTLSSLPAL PSLEGLTVRK LQLSMDPMLD 360
  361 MMGMQMLMEK YGDQAMAGMD HSQMMGHMGH GNMNHMNHGG KFDFHHANKI NGQAFDMNKP 420
  421 MFAAAKGQYE RWVISGVGDM MLHPFHIHGT QFRILSENGK PPAAHRAGWK DTVKVEGNVS 480
  481 EVLVKFNHDA PKEHAYMAHC HLLEHEDTGM MLGFTV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	97.30103
Match:	1kv7A
Description:	multi-copper oxidase CueO
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, oxidizing metal ions	1.55524630095061	bayes_pls_golite062009
binding	0.582547842165401	bayes_pls_golite062009
heme-copper terminal oxidase activity	0.379596275876029	bayes_pls_golite062009
catalytic activity	0.363071622766357	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.324410699993373	bayes_pls_golite062009
cytochrome-c oxidase activity	0.222255654263847	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors	0.222255654263847	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	0.222255654263847	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.142849955342033	bayes_pls_golite062009
protein binding	0.0393017564630179	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: