YRC Public Data Repository - Protein Structure Prediction

Protein:	CISY_ECOLI
Organism:	Escherichia coli
Length:	427 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CISY_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|67156800, gi\|... - gi\|67156800\|ref\|ZP_00418297.1\| Citrate synthase I [Azotobacter vinelandii AvOP], gi\|67085989\|gb\|EAM0... gi\|67156800 - gi\|67156800\|ref\|ZP_00418297.1\| Citrate synthase I [Azotobacter vinelandii AvOP]	603.0	[0..1]	[427..1]
gi\|110834362, gi... - gi\|110834362\|ref\|YP_693221.1\| type II citrate synthase [Alcanivorax borkumensis SK2], gi\|110647473\|e...	597.0	[0..1]	[427..1]
gi\|151937755, gi... - gi\|75854801\|ref\|ZP_00762474.1\| COG0372: Citrate synthase [Vibrio sp. Ex25], gi\|254229710\|ref\|ZP_0492... gi\|91188007, gi\|... - gi\|91228423\|ref\|ZP_01262348.1\| type II citrate synthase [Vibrio alginolyticus 12G01], gi\|91188007\|gb...	596.0	[0..1]	[427..1]
gi\|90411594, gi\|... - gi\|90411594\|ref\|ZP_01219604.1\| citrate synthase [Photobacterium profundum 3TCK], gi\|90327484\|gb\|EAS4...	595.0	[0..1]	[427..1]
CISY_PSEAE - Citrate synthase OS=Pseudomonas aeruginosa GN=gltA PE=3 SV=2 gi\|218772689, gi... - gi\|218892463\|ref\|YP_002441330.1\| type II citrate synthase [Pseudomonas aeruginosa LESB58], gi\|218772... gi\|116049525, gi... - gi\|116049525\|ref\|YP_791671.1\| type II citrate synthase [Pseudomonas aeruginosa UCBPP-PA14], gi\|11558... gi\|194550914, gi... - gi\|254239929\|ref\|ZP_04933251.1\| citrate synthase [Pseudomonas aeruginosa 2192], gi\|194550914\|ref\|YP_... gi\|254234681, gi... - gi\|254234681\|ref\|ZP_04928004.1\| citrate synthase [Pseudomonas aeruginosa C3719], gi\|194545666\|ref\|YP... CISY_PSEAE - Citrate synthase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=...	595.0	[0..1]	[427..1]
gi\|68234 - gi\|68234\|pir\|\|YKPSCA citrate (si)-synthase (EC 4.1.3.7) - Pseudomonas aeruginosa	594.0	[0..1]	[427..1]
tr\|A0A085R9U9\|A0... - Citrate synthase OS=Vibrio cholerae GN=gltA PE=3 SV=1 gi\|116189055 - gi\|116189055\|ref\|ZP_01478815.1\| hypothetical protein VchoM_02002077 [Vibrio cholerae MO10] gi\|75814751 - gi\|75814751\|ref\|ZP_00745304.1\| COG0372: Citrate synthase [Vibrio cholerae V52] gi\|116219290 - gi\|116219290\|ref\|ZP_01484794.1\| hypothetical protein VchoV5_02002610 [Vibrio cholerae V51]	594.0	[0..1]	[427..1]
gi\|37197954, gi\|... - gi\|37679211\|ref\|NP_933820.1\| type II citrate synthase [Vibrio vulnificus YJ016], gi\|37197954\|dbj\|BAC... gi\|27363645, gi\|... - gi\|27363645\|ref\|NP_759173.1\| type II citrate synthase [Vibrio vulnificus CMCP6], gi\|27359761\|gb\|AAO0...	594.0	[0..1]	[427..1]
gi\|121586945, gi... - gi\|121586945\|ref\|ZP_01676725.1\| citrate synthase [Vibrio cholerae 2740-80], gi\|121548881\|gb\|EAX58924... gi\|121630291, gi... - gi\|121727399\|ref\|ZP_01680538.1\| citrate synthase [Vibrio cholerae V52], gi\|121630291\|gb\|EAX62689.1\| ... gi\|153213722, gi... - gi\|153213722\|ref\|ZP_01948974.1\| citrate synthase [Vibrio cholerae 1587], gi\|124115783\|gb\|EAY34603.1\|... gi\|153222203, gi... - gi\|153222203\|ref\|ZP_01952982.1\| citrate synthase [Vibrio cholerae MAK 757], gi\|124119063\|gb\|EAY37806... gi\|197751657, gi... - gi\|254286791\|ref\|ZP_04961744.1\| citrate synthase [Vibrio cholerae AM-19226], gi\|197751657\|ref\|YP_002... gi\|124122480, gi... - gi\|153801966\|ref\|ZP_01956552.1\| citrate synthase [Vibrio cholerae MZO-3], gi\|124122480\|gb\|EAY41223.1... gi\|148873225, gi... - gi\|153831294\|ref\|ZP_01983961.1\| citrate synthase [Vibrio cholerae 623-39], gi\|148873225\|gb\|EDL71360.... gi\|126511070, gi... - gi\|153818380\|ref\|ZP_01971047.1\| citrate synthase [Vibrio cholerae NCTC 8457], gi\|126511070\|gb\|EAZ736... gi\|149740200, gi... - gi\|153826083\|ref\|ZP_01978750.1\| citrate synthase [Vibrio cholerae MZO-2], gi\|149740200\|gb\|EDM54353.1... gi\|153821712, gi... - gi\|229511944\|ref\|ZP_04401423.1\| citrate synthase (si) [Vibrio cholerae B33], gi\|229351909\|gb\|EEO1685... gi\|11268299 - pir\|\|B82119 citrate synthase VC2092 [imported] - Vibrio cholerae (strain N16961 serogroup O1) gi\|227082218, gi... - gi\|227082218\|ref\|YP_002810769.1\| citrate synthase [Vibrio cholerae M66-2], gi\|227010106\|gb\|ACP06318.... gi\|229355324, gi... - gi\|229507819\|ref\|ZP_04397324.1\| citrate synthase (si) [Vibrio cholerae BX 330286], gi\|229355324\|gb\|E... gi\|229513747, gi... - gi\|229513747\|ref\|ZP_04403209.1\| citrate synthase (si) [Vibrio cholerae TMA 21], gi\|229348928\|gb\|EEO1... gi\|229343769, gi... - gi\|229519080\|ref\|ZP_04408523.1\| citrate synthase (si) [Vibrio cholerae RC9], gi\|229343769\|gb\|EEO0874... gi\|229522049, gi... - gi\|229522049\|ref\|ZP_04411466.1\| citrate synthase (si) [Vibrio cholerae TM 11079-80], gi\|229340974\|gb... gi\|229337679, gi... - gi\|229524098\|ref\|ZP_04413503.1\| citrate synthase (si) [Vibrio cholerae bv. albensis VL426], gi\|22933... gi\|15642092, gi\|... - gi\|9656641\|gb\|AAF95238.1\| citrate synthase [Vibrio cholerae O1 biovar El Tor str. N16961], gi\|156420... gi\|229332666, gi... - gi\|229528892\|ref\|ZP_04418282.1\| citrate synthase (si) [Vibrio cholerae 12129(1)], gi\|229332666\|gb\|EE... gi\|254849178, gi... - gi\|75829406\|ref\|ZP_00758710.1\| COG0372: Citrate synthase [Vibrio cholerae MO10], gi\|254849178\|ref\|ZP... gi\|229370019, gi... - gi\|229607364\|ref\|YP_002878012.1\| citrate synthase (si) [Vibrio cholerae MJ-1236], gi\|229370019\|gb\|AC... gi\|146315819, gi... - gi\|75827399\|ref\|ZP_00756834.1\| COG0372: Citrate synthase [Vibrio cholerae O395], gi\|227118539\|ref\|YP... gi\|125621408, gi... - gi\|75818585\|ref\|ZP_00748728.1\| COG0372: Citrate synthase [Vibrio cholerae V51], gi\|254226096\|ref\|ZP_...	593.0	[0..1]	[427..3]

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Predicted Domain #1

Region A:
Residues: [1-427]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADTKAKLTL NGDTAVELDV LKGTLGQDVI DIRTLGSKGV FTFDPGFTST ASCESKITFI  60
   61 DGDEGILLHR GFPIDQLATD SNYLEVCYIL LNGEKPTQEQ YDEFKTTVTR HTMIHEQITR 120
  121 LFHAFRRDSH PMAVMCGITG ALAAFYHDSL DVNNPRHREI AAFRLLSKMP TMAAMCYKYS 180
  181 IGQPFVYPRN DLSYAGNFLN MMFSTPCEPY EVNPILERAM DRILILHADH EQNASTSTVR 240
  241 TAGSSGANPF ACIAAGIASL WGPAHGGANE AALKMLEEIS SVKHIPEFVR RAKDKNDSFR 300
  301 LMGFGHRVYK NYDPRATVMR ETCHEVLKEL GTKDDLLEVA MELENIALND PYFIEKKLYP 360
  361 NVDFYSGIIL KAMGIPSSMF TVIFAMARTV GWIAHWSEMH SDGMKIARPR QLYTGYEKRD 420
  421 FKSDIKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	167.0
Match:	1owbA
Description:	Three Dimensional Structure Analysis Of The Variant R109L NADH Complex of Type II Citrate Synthase From E. Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
citrate (Si)-synthase activity	7.90380661459876	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	7.35970609422108	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.98392594633005	bayes_pls_golite062009
catalytic activity	2.51855037019879	bayes_pls_golite062009
transferase activity	2.22659761972612	bayes_pls_golite062009
binding	1.15467737113069	bayes_pls_golite062009
protein binding	0.210158634792359	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: